scholarly journals Malaria Vaccines

2012 ◽  
pp. 171-197
Author(s):  
Christopher V. Plowe
Keyword(s):  
Malaria Vaccines

Design and methodology of field-based intervention trials of malaria vaccines

1995 ◽  
Vol 11 (6) ◽  
pp. 197-200 ◽  
Author(s):  
P.L. Alonso ◽  
M.E. Molyneux ◽  
T. Smith
Keyword(s):  
Malaria Vaccines ◽  
Intervention Trials

scholarly journals Incidence of Plasmodium falciparum malaria infection in 6-month to 45-year-olds on selected areas of Bioko Island, Equatorial Guinea

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Vicente Urbano Nsue Ndong Nchama ◽  
Ali Hamad Said ◽  
Ali Mtoro ◽  
Gertrudis Owono Bidjimi ◽  
Marta Alene Owono ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Malaria Control ◽  
Malaria Infection ◽  
Age Groups ◽  
Control Measures ◽  
Equatorial Guinea ◽  
Safety And Efficacy ◽  
Bioko Island ◽  
Malaria Vaccines

Abstract Background Extensive malaria control measures have been implemented on Bioko Island, Equatorial Guinea over the past 16 years, reducing parasite prevalence and malaria-related morbidity and mortality, but without achieving elimination. Malaria vaccines offer hope for reducing the burden to zero. Three phase 1/2 studies have been conducted successfully on Bioko Island to evaluate the safety and efficacy of whole Plasmodium falciparum (Pf) sporozoite (SPZ) malaria vaccines. A large, pivotal trial of the safety and efficacy of the radiation-attenuated Sanaria® PfSPZ Vaccine against P. falciparum is planned for 2022. This study assessed the incidence of malaria at the phase 3 study site and characterized the influence of socio-demographic factors on the burden of malaria to guide trial design. Methods A cohort of 240 randomly selected individuals aged 6 months to 45 years from selected areas of North Bioko Province, Bioko Island, was followed for 24 weeks after clearance of parasitaemia. Assessment of clinical presentation consistent with malaria and thick blood smears were performed every 2 weeks. Incidence of first and multiple malaria infections per person-time of follow-up was estimated, compared between age groups, and examined for associated socio-demographic risk factors. Results There were 58 malaria infection episodes observed during the follow up period, including 47 first and 11 repeat infections. The incidence of malaria was 0.25 [95% CI (0.19, 0.32)] and of first malaria was 0.23 [95% CI (0.17, 0.30)] per person per 24 weeks (0.22 in 6–59-month-olds, 0.26 in 5–17-year-olds, 0.20 in 18–45-year-olds). Incidence of first malaria with symptoms was 0.13 [95% CI (0.09, 0.19)] per person per 24 weeks (0.16 in 6–59-month-olds, 0.10 in 5–17-year-olds, 0.11 in 18–45-year-olds). Multivariate assessment showed that study area, gender, malaria positivity at screening, and household socioeconomic status independently predicted the observed incidence of malaria. Conclusion Despite intensive malaria control efforts on Bioko Island, local transmission remains and is spread evenly throughout age groups. These incidence rates indicate moderate malaria transmission which may be sufficient to support future larger trials of PfSPZ Vaccine. The long-term goal is to conduct mass vaccination programmes to halt transmission and eliminate P. falciparum malaria.

In Reply: Malaria Vaccines

Science ◽  
1990 ◽  
Vol 248 (4954) ◽  
pp. 422-422 ◽  
Author(s):  
D. Herrington ◽  
S. L. Hoffman ◽  
M. M. Levine ◽  
D. M. Gordon
Keyword(s):  
Malaria Vaccines

scholarly journals A new tool for testing malaria vaccines

2003 ◽  
Vol 3 (1) ◽  
pp. 5-5
Author(s):  
Elaine Bell
Keyword(s):  
Malaria Vaccines

A multi-bioreactor system for optimal production of malaria vaccines with Pichia pastoris

2011 ◽  
Vol 6 (4) ◽  
pp. 437-451 ◽  
Author(s):  
Jens Fricke ◽  
Kristof Pohlmann ◽  
Frithjof Tatge ◽  
Roman Lang ◽  
Bart Faber ◽  
...  
Keyword(s):  
Pichia Pastoris ◽  
Optimal Production ◽  
Malaria Vaccines ◽  
Bioreactor System

scholarly journals Letter: Malaria vaccines.

BMJ ◽  
1975 ◽  
Vol 3 (5974) ◽  
pp. 39-40
Author(s):  
K N Brown
Keyword(s):  
Malaria Vaccines

scholarly journals TRANSVAC workshop on standardisation and harmonisation of analytical platforms for HIV, TB and malaria vaccines: ‘How can big data help?’

Vaccine ◽  
2014 ◽  
Vol 32 (35) ◽  
pp. 4365-4368 ◽  
Author(s):  
Céline Dutruel ◽  
Jelle Thole ◽  
Mark Geels ◽  
Hans-Joachim Mollenkopf ◽  
Tom Ottenhoff ◽  
...  
Keyword(s):  
Big Data ◽  
Malaria Vaccines ◽  
Analytical Platforms

scholarly journals Humanized Mouse Models to Study Cell-Mediated Immune Responses to Liver-Stage Malaria Vaccines

2015 ◽  
Vol 31 (11) ◽  
pp. 583-594 ◽  
Author(s):  
Michael F. Good ◽  
Michael T. Hawkes ◽  
Stephanie K. Yanow
Keyword(s):  
Immune Responses ◽  
Mouse Models ◽  
Humanized Mouse ◽  
Liver Stage ◽  
Malaria Vaccines ◽  
Humanized Mouse Models
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