Percutaneous Pancreatic Islet Cell Transplantation

2013 ◽  
pp. 1223-1228
Author(s):  
Felix Y. Yap ◽  
Raquel Garcia-Roca ◽  
Jose Oberholzer ◽  
Ron C. Gaba
Keyword(s):  
Cell Transplantation ◽  
Pancreatic Islet ◽  
Islet Cell ◽  
Islet Cell Transplantation ◽  
Pancreatic Islet Cell

Pancreatic Islet Cell Transplantation: Update and New Developments

2007 ◽  
Vol 22 (5) ◽  
pp. 485-493 ◽  
Author(s):  
Nicholas Onaca ◽  
Bashoo Naziruddin ◽  
Shinichi Matsumoto ◽  
Hirofumi Noguchi ◽  
Goran B. Klintmalm ◽  
...  
Keyword(s):  
Cell Transplantation ◽  
Pancreatic Islet ◽  
Islet Cell ◽  
Islet Cell Transplantation ◽  
Pancreatic Islet Cell ◽  
New Developments

scholarly journals Mechanisms of Angiogenesis Process after Pancreatic Islet Cell Transplantation: Role of Intra-islet Endothelial Cells

2017 ◽  
Vol 07 (01) ◽  
Author(s):  
Siddharth Narayanan ◽  
Gopalakrishnan Loganathan ◽  
Maheswaran Dhanasekaran ◽  
Michael J Hughes ◽  
Stuart K Williams ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Cell Transplantation ◽  
Pancreatic Islet ◽  
Islet Cell ◽  
Islet Cell Transplantation ◽  
Pancreatic Islet Cell ◽  
Angiogenesis Process

scholarly journals A Case of Pancreatic Islet Cell Transplantation in a Patient with Situs Ambiguous: Anatomical and Radiological Considerations

2007 ◽  
Vol 24 (1) ◽  
pp. 043-046
Author(s):  
Rajesh Shah ◽  
James Bui ◽  
Derek West ◽  
Jose Oberholzer ◽  
Betul Hatipoglu ◽  
...  
Keyword(s):  
Cell Transplantation ◽  
Pancreatic Islet ◽  
Islet Cell ◽  
Islet Cell Transplantation ◽  
Pancreatic Islet Cell ◽  
Situs Ambiguous

Modified gold nanoparticle vectors: A biocompatible intracellular delivery system for pancreatic islet cell transplantation

Surgery ◽  
2010 ◽  
Vol 148 (4) ◽  
pp. 858-866 ◽  
Author(s):  
Rafael A. Vega ◽  
Yong Wang ◽  
Tricia Harvat ◽  
Shusen Wang ◽  
Merigeng Qi ◽  
...  
Keyword(s):  
Gold Nanoparticle ◽  
Cell Transplantation ◽  
Pancreatic Islet ◽  
Delivery System ◽  
Islet Cell ◽  
Intracellular Delivery ◽  
Islet Cell Transplantation ◽  
Pancreatic Islet Cell

scholarly journals Potential Benefits of Nrf2/Keap1 Targeting in Pancreatic Islet Cell Transplantation

Antioxidants ◽  
2020 ◽  
Vol 9 (4) ◽  
pp. 321 ◽  
Author(s):  
Alberto Jarrin Lopez ◽  
Hien Lau ◽  
Shiri Li ◽  
Hirohito Ichii
Keyword(s):  
Cell Transplantation ◽  
Pancreatic Islet ◽  
Islet Cell ◽  
Islet Cells ◽  
Therapeutic Option ◽  
Inflammatory Cells ◽  
Cell Integrity ◽  
Islet Cell Transplantation ◽  
Pancreatic Islet Cell ◽  
Antioxidant Genes

Permanent pancreatic islet cell destruction occurs in type 1 diabetes mellitus (T1DM) through the infiltration of inflammatory cells and cytokines. Loss of β-cell integrity secondary to oxidation leads to an inability to appropriately synthesize and secrete insulin. Allogenic islet cell transplantation (ICT) has risen as a therapeutic option to mitigate problematic hypoglycemia. Nevertheless, during the process of transplantation, islet cells are exposed to oxidatively caustic conditions that severely decrease the islet cell yield. Islet cells are at a baseline disadvantage to sustain themselves during times of metabolic stress as they lack a robust anti-oxidant defense system, glycogen stores, and vascularity. The Nrf2/Keap1 system is a master regulator of antioxidant genes that has garnered attention as pharmacologic activators have shown a protective response and a low side effect profile. Herein, we present the most recently studied Nrf2/Keap1 activators in pancreas for application in ICT: Dh404, dimethyl fumarate (DMF), and epigallocatechin gallate (EGCG). Furthermore, we discuss that Nrf2/Keap1 is a potential target to ameliorate oxidative stress at every step of the Edmonton Protocol.

Pancreatic Islet Cell Transplantation

Drugs ◽  
2001 ◽  
Vol 61 (14) ◽  
pp. 2017-2020 ◽  
Author(s):  
R. Paul Robertson
Keyword(s):  
Cell Transplantation ◽  
Pancreatic Islet ◽  
Islet Cell ◽  
Islet Cell Transplantation ◽  
Pancreatic Islet Cell
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