Opioid Peptides and Vasopressin

1986 ◽  
pp. 49-62 ◽  
Author(s):  
Thomas G. Sherman ◽  
Jeffrey E. Kelsey ◽  
Henry Khachaturian ◽  
Sharon Burke ◽  
Huda Akil ◽  
...  
Keyword(s):  
Opioid Peptides

Alleviation of pain and depression by specific neural transplants: Fine structural correlates

1992 ◽  
Vol 50 (2) ◽  
pp. 1066-1067
Author(s):  
George D. Pappas ◽  
Jacqueline Sagen
Keyword(s):  
Opioid Peptides ◽  
Chromaffin Cells ◽  
Pain Sensitivity ◽  
Opioid Peptide ◽  
Local Source ◽  
Pain Models ◽  
Neural Transplants ◽  
Adrenergic Antagonists ◽  
Csf Levels ◽  
Donor Source

We have been interested in the use of neural transplants mainly as a local source of neuroactive substances, rather than as a replacement for damaged neural circuities. In particular, we have been exploring the possibilities of reducing pain by transplants of opioid peptide producing cells, and reducing depression by transplants of monoamine-producing cells. For the past several years, work in our laboratory has demonstrated in both acute and chronic pain models that transplantation of adrenal medullary tissue or isolated chromaffin cells into CNS pain modulatory regions can reduce pain sensitivity in rodents. Chromaffin cells were chosen as donor source since they produce high levels of both opioid peptides and catecholamines, substances which independently, and probably synergistically, reduce pain sensitivity when injected locally into the spinal cord. The analgesia produced by these transplants most likely results from the release of both opioid peptides and catecholamines, since it can be blocked or attenuated by opiate or adrenergic antagonists, respectively. Furthermore, CSF levels of met-enkephalin and catecholamines are increased by the transplants.

Effects of Opioid Peptides on Human Neuroblastoma Cells

1988 ◽  
Author(s):  
Wolfgang Sadee ◽  
Victor C. Yu ◽  
Gunther Hochhaus
Keyword(s):  
Opioid Peptides ◽  
Neuroblastoma Cells ◽  
Human Neuroblastoma Cells ◽  
Human Neuroblastoma

Modified Solid-Phase Methods for the Rapid Synthesis of Opioid Peptides

1991 ◽  
Author(s):  
Richard A. Houghten ◽  
◽  
John M. Ostresh ◽  
Suzanne M. Pratt
Keyword(s):  
Opioid Peptides ◽  
Solid Phase ◽  
Rapid Synthesis

Opioid peptides in rat islets of Langerhans. Immunoreactive met- and leu-enkephalins and BAM-22P

Diabetes ◽  
1986 ◽  
Vol 35 (1) ◽  
pp. 52-57 ◽  
Author(s):  
K. I. Timmers ◽  
N. R. Voyles ◽  
C. King ◽  
M. Wells ◽  
R. Fairtile ◽  
...  
Keyword(s):  
Islets Of Langerhans ◽  
Opioid Peptides ◽  
Rat Islets ◽  
Rat Islets Of Langerhans

Production and release of the opioid peptides induced by bradykinin in the tooth pulp.

Ensho ◽  
1987 ◽  
Vol 7 (2) ◽  
pp. 181-185
Author(s):  
Teruo Kudo ◽  
Masato Kuroi ◽  
Huei-Ling Chang ◽  
Reizo Inoki
Keyword(s):  
Opioid Peptides ◽  
Tooth Pulp

scholarly journals Proteases as catalysts for enzymic syntheses of opioid peptides.

1980 ◽  
Vol 255 (17) ◽  
pp. 8234-8238
Author(s):  
W. Kullmann
Keyword(s):  
Opioid Peptides
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