Physiologic Models of Hepatic Drug Elimination

New Trends in Pharmacokinetics ◽

10.1007/978-1-4684-8053-5_6 ◽

1991 ◽

pp. 83-102 ◽

Author(s):

Malcolm Rowland ◽

Allan M. Evans

Keyword(s):

Drug Elimination ◽

Hepatic Drug ◽

Physiologic Models

Download Full-text

A physiologically-based flow network model for hepatic drug elimination I: regular lattice lobule model

Theoretical Biology and Medical Modelling ◽

10.1186/1742-4682-10-52 ◽

2013 ◽

Vol 10 (1) ◽

pp. 52 ◽

Author(s):

Vahid Rezania ◽

Rebeccah Marsh ◽

Dennis Coombe ◽

Jack Tuszynski

Keyword(s):

Network Model ◽

Drug Elimination ◽

Regular Lattice ◽

Hepatic Drug ◽

Flow Network ◽

Physiologically Based

Download Full-text

On the validity of the dispersion model of hepatic drug elimination when intravascular transit time densities are long-tailed

Bulletin of Mathematical Biology ◽

10.1007/bf02459999 ◽

1997 ◽

Vol 59 (5) ◽

pp. 911-929 ◽

Author(s):

Michael Weiss ◽

Christina Stedtler ◽

Michael S. Roberts

Keyword(s):

Transit Time ◽

Dispersion Model ◽

Drug Elimination ◽

Download Full-text

The effect of cimetidine on hepatic drug elimination in cirrhosis

10.1002/hep.1840050226 ◽

1985 ◽

Vol 5 (2) ◽

pp. 305-309 ◽

Author(s):

Donald C. Nelson ◽

George R. Avant ◽

K. Vincent Speeg ◽

Anastacio M. Hoyumpa ◽

Steven Schenker

Keyword(s):

Drug Elimination ◽

Download Full-text

Physiologic Models of Hepatic Drug Clearance: Influence of Altered Protein Binding on the Elimination of Diclofenac in the Isolated Perfused Rat Liver

Journal of Pharmaceutical Sciences ◽

10.1002/jps.2600820904 ◽

1993 ◽

Vol 82 (9) ◽

pp. 880-885 ◽

Author(s):

Ziad Hussein ◽

Allan M. Evans ◽

Malcolm Rowland

Keyword(s):

Protein Binding ◽

Rat Liver ◽

Drug Clearance ◽

Isolated Perfused Rat Liver ◽

Perfused Rat Liver ◽

Hepatic Drug ◽

Altered Protein ◽

Physiologic Models

Download Full-text

Methods to study mechanisms underlying altered hepatic drug elimination during pregnancy

Seminars in Perinatology ◽

10.1016/j.semperi.2020.151228 ◽

2020 ◽

Vol 44 (3) ◽

pp. 151228 ◽

Author(s):

Hyunyoung Jeong ◽

Catherine S. Stika

Keyword(s):

Drug Elimination ◽

Download Full-text

H2-receptor blocking agents and hepatic drug elimination

Clinical Pharmacology & Therapeutics ◽

10.1038/clpt.1987.202 ◽

1987 ◽

Vol 42 (5) ◽

pp. 595-595 ◽

Author(s):

Ulrich Klotz

Keyword(s):

Drug Elimination ◽

Hepatic Drug ◽

Receptor Blocking ◽

H2 Receptor ◽

Blocking Agents

Download Full-text

Models of Hepatic Drug Elimination

Drug Metabolism Reviews ◽

10.3109/03602539208996290 ◽

1992 ◽

Vol 24 (1) ◽

pp. 49-88 ◽

Author(s):

Bradley A. Saville ◽

Murray R. Gray ◽

Yun K. Tam

Keyword(s):

Drug Elimination ◽

Download Full-text

Use of Unbound Drug Concentration in Blood to Discriminate Between Two Models of Hepatic Drug Elimination

Journal of Pharmaceutical Sciences ◽

10.1002/jps.2600710536 ◽

1982 ◽

Vol 71 (5) ◽

pp. 600-602 ◽

Author(s):

Denis J. Morgan ◽

Kenneth Raymond

Keyword(s):

Drug Concentration ◽

Drug Elimination ◽

Download Full-text

Variation in Hepatic Extraction Ratio with Unbound Drug Fraction: Discrimination Between Models of Hepatic Drug Elimination

Journal of Pharmaceutical Sciences ◽

10.1002/jps.2600740221 ◽

1985 ◽

Vol 74 (2) ◽

pp. 205-207 ◽

Author(s):

Amanda J. Byrne ◽

Denis J. Morgan ◽

Paul M. Harrison ◽

Allan J. McLean

Keyword(s):

Extraction Ratio ◽

Drug Elimination ◽

Hepatic Extraction ◽

Hepatic Drug ◽

Hepatic Extraction Ratio

Download Full-text

On the validity of the dispersion model of hepatic drug elimination when intravascular transit time densities are long-tailed

Bulletin of Mathematical Biology ◽

10.1016/s0092-8240(97)00036-0 ◽

1997 ◽

Vol 59 (5) ◽

pp. 911-929 ◽

Author(s):

M Weiss

Keyword(s):

Transit Time ◽

Dispersion Model ◽

Drug Elimination ◽

Download Full-text