Use of Unbound Drug Concentration in Blood to Discriminate Between Two Models of Hepatic Drug Elimination

1982 ◽  
Vol 71 (5) ◽  
pp. 600-602 ◽  
Author(s):  
Denis J. Morgan ◽  
Kenneth Raymond
Keyword(s):  
Drug Concentration ◽  
Drug Elimination ◽  
Hepatic Drug

Removal of Vitamin B6 (Pyridoxine) Antibiotics Pharmaceuticals From Aqueous Systems By ZnO

2019 ◽  
Vol 9 (02) ◽  
Author(s):  
Aseel M. Aljeboree
Keyword(s):  
Metal Ions ◽  
Drug Concentration ◽  
Vitamin B6 ◽  
Water Adsorption ◽  
Pharmaceutical Products ◽  
Drug Elimination ◽  
Maximum Capacity ◽  
Pharmaceutical Drug ◽  
Freundlich Isotherms ◽  
Initial Drug

Pharmaceutical products are being increasingly discovered, in the environment. However, traditional treating systems do not provide an adequate remedy, for pharmaceutical drug elimination and still there is not a regulated criterion for their limitation in water. Adsorption is one of the most efficient and practical techniques to remove pollutants from water. ZnO to be used as adsorbent being abundant and cheap has removal capabilities for certain pollutants from water such as drug,drug, metal ions, phenol, and different anions. In this paper the potential of ZnO for removal of vitamin B6 has been discussed. Different parameters like, initial drug concentration (5-80 mg/L), temperature (15, 25, and 50 ºC), adsorbent dosage (0.001-0.15gm), were investigated. The adsorption of drug was best at neutral pH. The adsorption uptake decrease with increase in initial drug concentration, but increase with the amount of adsorbent and temperature. The equilibrium was evaluated using Langmuir, Freundlich isotherms. The maximum capacity of adsorption obtained from the Freundlichmodel was 108.556mg/g.

scholarly journals Contamination of Human Milk by Drugs and Chemicals

1983 ◽  
Vol 2 (3-4) ◽  
pp. 191-201 ◽  
Author(s):  
John T. Wilson
Keyword(s):  
Breast Milk ◽  
Human Milk ◽  
Drug Concentration ◽  
Drug Disposition ◽  
Drug Dose ◽  
Drug Accumulation ◽  
Drug Elimination ◽  
Drug Excretion ◽  
Toxic Agents

Three major areas are emphasized for a study of drug excretion in breast milk: maternal drug disposition, breast milk pharmacokinetics and neonatal drug elimination. The first two impact on drug dose to infant whereas the last area is crucial to drug accumulation in the infant. Pitfalls in assessment of the drug concentration in milk to plasma (M/P) ratio are illustrated to expose errors in drug dose in milk estimates. Predictions about drug dose in milk must be confirmed by sampling of both milk and infant plasma for drug concentration. Principles for drug excretion in breast milk can be used as guidelines for excretion of a growing number of toxic agents.

The effect of cimetidine on hepatic drug elimination in cirrhosis

Hepatology ◽  
1985 ◽  
Vol 5 (2) ◽  
pp. 305-309 ◽  
Author(s):  
Donald C. Nelson ◽  
George R. Avant ◽  
K. Vincent Speeg ◽  
Anastacio M. Hoyumpa ◽  
Steven Schenker
Keyword(s):  
Drug Elimination ◽  
Hepatic Drug

Models of Hepatic Drug Elimination

1992 ◽  
Vol 24 (1) ◽  
pp. 49-88 ◽  
Author(s):  
Bradley A. Saville ◽  
Murray R. Gray ◽  
Yun K. Tam
Keyword(s):  
Drug Elimination ◽  
Hepatic Drug
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