We extend to a situation involving matrix-valued orthogonal polynomials a scalar result that plays an important role in Random Matrix Theory and a few other areas of mathe-matics and signal processing. We consider a case of matrix-valued Jacobi polynomials which arises from the study of representations of [Formula: see text], a group that plays an important role in Random Matrix Theory. We show that in this case an algebraic miracle, namely the existence of a differential operator that commutes with a naturally arising integral one, extends to this matrix-valued situation.