Pineal Tumors

Postgraduate Medical Journal ◽

10.1136/pgmj.55.648.772-c ◽

1979 ◽

Vol 55 (648) ◽

pp. 772-773

Keyword(s):

Pineal Tumors

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Midline Pineal Tumors and Suprasellar Germinomas: Highly Curable by Irradiation

Radiology ◽

10.1148/128.3.745 ◽

1978 ◽

Vol 128 (3) ◽

pp. 745-751 ◽

Cited By ~ 173

Author(s):

Duk Il Sung ◽

Leon Harisiadis ◽

Chu H. Chang

Keyword(s):

Pineal Tumors

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Interhemispheric transcallosal intervenous approach to a pineal region tumor

Neurosurgical Focus: Video ◽

10.3171/2021.4.focvid2120 ◽

2021 ◽

Vol 5 (1) ◽

pp. V11

Author(s):

Daniel A. Donoho ◽

Guillermo Aldave

Keyword(s):

Extent Of Resection ◽

Pineal Region ◽

Cerebral Veins ◽

Surgical Morbidity ◽

Pineal Tumors ◽

Pineal Region Tumor ◽

Pineal Region Tumors ◽

Transcallosal Approach ◽

Formidable Challenge ◽

The Right

Pineal region tumors represent a formidable challenge to the neurosurgeon. Choosing the right approach is key to optimizing the extent of resection and minimizing surgical morbidity. In this video, the authors show an interhemispheric transcallosal approach to a pineal region tumor in a 15-year-old boy. The advantage of this corridor over posterior approaches is that it provides a nice view of the tumor plane with the venous complex, especially while dissecting tumor from the anterior aspect of the internal cerebral veins on their vertical path. Thus, this approach represents a safe and effective alternative for selected pineal tumors. The video can be found here: https://stream.cadmore.media/r10.3171/2021.4.FOCVID2120.

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Reversible hearing loss associated with a malignant pineal germ cell tumor

Journal of Neurosurgery ◽

10.3171/jns.2003.99.3.0587 ◽

2003 ◽

Vol 99 (3) ◽

pp. 587-590 ◽

Cited By ~ 7

Author(s):

Nathalie Gaspar ◽

Arnauld Verschuur ◽

Ghislaine Mercier ◽

Dominique Couanet ◽

Christian Sainte-Rose ◽

...

Keyword(s):

Hearing Loss ◽

Germ Cell ◽

Germ Cell Tumor ◽

Clinical Symptoms ◽

Tumor Regression ◽

Cell Tumor ◽

Direct Compression ◽

Pineal Tumors ◽

Content Type ◽

Adjacent Structures

✓ In patients with pineal tumors, clinical symptoms are due to direct compression of adjacent structures. The most common signs include increased intracranial pressure (80%) caused by obstruction of the sylvian aqueduct, and Parinaud syndrome (50%) caused by direct compression of the superior colliculi. Hearing loss is rare in patients with tumors in this location. The authors report on the case of a 12-year-old boy in whom a malignant pineal germ cell tumor was found together with the unusual occurrence of severe hearing loss due to direct bilateral compression of the inferior colliculi. This condition resolved completely after tumor regression.

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Pineal Tumors

Encyclopedia of Clinical Neuropsychology ◽

10.1007/978-3-319-56782-2_142-2 ◽

2017 ◽

pp. 1-2

Author(s):

Mi-Yeoung Jo

Keyword(s):

Pineal Tumors

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P14.50 Clinicopathological spectrum of intracranial germ cell tumors: an Indian tertiary cancer center experience

Neuro-Oncology ◽

10.1093/neuonc/noz126.285 ◽

2019 ◽

Vol 21 (Supplement_3) ◽

pp. iii78-iii78

Author(s):

A Sahay ◽

G Chinnaswamy ◽

V Bhat ◽

V Patil ◽

T Gupta ◽

...

Keyword(s):

Brain Tumors ◽

Germ Cell ◽

Tumor Markers ◽

Posterior Fossa ◽

Germ Cell Tumors ◽

Clinicopathological Features ◽

Spinal Tumors ◽

Equal Distribution ◽

Pineal Tumors ◽

Intracranial Germ Cell Tumors

Abstract BACKGROUND Incidence of intracranial germ cell tumors (ICGCT) in Western literature is low (0.3–0.6 %) as compared to East Asia (3–4 %), & their clinicopathological features are well documented. However, there are scant studies on ICGCT from India. MATERIAL AND METHODS Retrospective observational study of all ICGCT histologically diagnosed in our hospital from 2007–2018. Metastasis were excluded. Clinicopathological features were retrieved from hospital’s electronic medical records. RESULTS We diagnosed 82 primary ICGCT, forming approx. 0.54 % of all primary brain tumors, & 3.5% of pediatric brain tumors. Age range: 2 months-32 yrs (Median age 14 yrs). M:F ratio: 1.82:1 (53M,29F). Nearly 80% patients were pediatric (<18 yrs), & 8 very young (<3 yrs, 7M1F). Majority were suprasellar & pineal (31/82, 37% each), with one bifocal presentation. Other rarer sites: posterior fossa (4), midbrain (1), corpus callosum (1) & 11 non midline (4 thalamic, 4 frontal, 2 cerebellar, 1 CP angle). Predominant histology was germinoma (G) (51/82, 62%), while non germinomatous (NGGCT) were 31/82 (38%), of which 9 were mixed. Pure teratoma were 11 (9 immature (IT), 2 mature), & 5 pure yolk sac tumor (YST). Interestingly, all very young age group patients (<3 yrs), showed only NGGCT histology (5/8 IT, 3/8 pure YST). In contrast, G histology formed nearly 70% of all patients >3 yrs. Females were associated mainly with G (21/29, 72%). NGGCT were predominantly seen in males (M:F=2.9:1). Also, pure IT (9) were seen only in males. Posterior fossa tumors were all IT (4/4). Spinal tumors were NGGCT (1 mature teratoma, 1 YST). Majority of suprasellar tumors (25/31, 80.6%), other midline locations like corpus callosal, midbrain, & all thalamic tumors were G. However, pineal tumors showed equal distribution of G (15/31) & NGGCT (16/31). Spine screening was positive in 8 patients (6 G, 2 IT)- 7 on MRI and 1 only on CSF cytology. Serum tumor markers were raised in 13/54 cases- 6/34G(17.6%), vs 7/20 NGGCT (35%). CSF tumor markers were raised in 14/34-10/23 G (43.4%), vs 4/11 NGGCT (36.3%). Follow up was available for 37 patients (Duration 3 months-10 yrs, median 2 yrs). On f/u 6/15 (40%) NGGCT showed progression/death, while only 2/32 G relapsed (6.5%). Four deaths in G group were not directly attributable to the tumor. CONCLUSION Frequency of ICGCT in our hospital similar to western data rather than Asian, albeit with less striking male preponderance. ICGCT were tumors of 2nd decade & majority occurred in pineal/suprasellar areas. About 2/3rd were pure G on histology, and showed good prognosis. NGGCT were common in infants, males and in posterior fossa. IT were seen exclusively in males and pure YST mainly in males. Although majority of ICGCT are in midline, rarely non midline involvement also occurs, and it’s essential to exclude metastasis before considering primary ICGCT. Expectedly, NGGCT showed poorer prognosis, compared to pure germinomas.

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