Effects of extraneuronal uptake inhibitors on the positive chronotropic response to isoprenaline and on the accumulation of isoprenaline in perfused rat heart after inhibition of catechol-O-methyl transferase

1987 ◽  
Vol 335 (2) ◽  
Author(s):  
Tatsuo Magaribuchi ◽  
Teruo Hama ◽  
Kazuyoshi Kurahashi ◽  
Motohatsu Fujiwara
Keyword(s):  
Rat Heart ◽  
Extraneuronal Uptake ◽  
Methyl Transferase ◽  
Perfused Rat Heart ◽  
Chronotropic Response ◽  
Uptake Inhibitors

scholarly journals INHIBITION OF NEURONAL AND EXTRANEURONAL UPTAKE OF NORADRENALINE BY KETAMINE IN THE ISOLATED PERFUSED RAT HEART

1979 ◽  
Vol 51 (9) ◽  
pp. 835-838 ◽  
Author(s):  
P.J. SALT ◽  
P.K. BARNES ◽  
F.J. BESWICK
Keyword(s):  
Rat Heart ◽  
Extraneuronal Uptake ◽  
Perfused Rat Heart ◽  
Isolated Perfused Rat Heart ◽  
Uptake Of Noradrenaline

The neuronal and extraneuronal uptake and metabolism of 3H-(?)-noradrenaline in the perfused rat heart

1978 ◽  
Vol 303 (1) ◽  
pp. 21-35 ◽  
Author(s):  
E. R. Fiebig ◽  
U. Trendelenburg
Keyword(s):  
Rat Heart ◽  
Extraneuronal Uptake ◽  
Perfused Rat Heart ◽  
Uptake And Metabolism

scholarly journals Effects of uptake inhibitors on the positive chronotropic action and on the accumulation2 of 3H-isoprenaline in perfused rat heart

1986 ◽  
Vol 40 ◽  
pp. 98
Author(s):  
Tatsuo Magaribuchi ◽  
Kazuyoshi Kurahashi ◽  
Motohatsu Fujiwara
Keyword(s):  
Rat Heart ◽  
Perfused Rat Heart ◽  
Uptake Inhibitors ◽  
Chronotropic Action

Effects of blockade of extraneuronal uptake on responses to isoprenaline in perfused rat heart

1975 ◽  
Vol 2 (3) ◽  
pp. 249-259 ◽  
Author(s):  
Gwynneth M. Picken ◽  
B. Jarrott
Keyword(s):  
Rat Heart ◽  
Extraneuronal Uptake ◽  
Perfused Rat Heart

Effects of specific α-adrenoceptive agents on extraneuronal uptake (uptake2) of isoproterenol in perfused rat heart

Life Sciences ◽  
1989 ◽  
Vol 44 (14) ◽  
pp. 945-950 ◽  
Author(s):  
Yoshinobu Akimoto ◽  
Kazami Sono ◽  
Kazuyoshi Kurahashi ◽  
Motohatsu Fujiwara
Keyword(s):  
Rat Heart ◽  
Extraneuronal Uptake ◽  
Perfused Rat Heart

Temperature sensitivity of the extraneuronal uptake and metabolism of isoprenaline in the perfused rat heart

1979 ◽  
Vol 306 (3) ◽  
pp. 229-239 ◽  
Author(s):  
H. B�nisch ◽  
W. Uhlig ◽  
U. Trendelenburg
Keyword(s):  
Temperature Sensitivity ◽  
Rat Heart ◽  
Extraneuronal Uptake ◽  
Perfused Rat Heart ◽  
Uptake And Metabolism

Temporal dynamics of inotropic, chronotropic, and metabolic responses during β1- and β2-AR stimulation in the isolated, perfused rat heart

2005 ◽  
Vol 289 (3) ◽  
pp. E412-E418 ◽  
Author(s):  
P. McConville ◽  
R. G. Spencer ◽  
E. G. Lakatta
Keyword(s):  
Rat Heart ◽  
Temporal Dynamics ◽  
High Energy ◽  
Left Ventricular ◽  
Metabolic Responses ◽  
Inotropic Response ◽  
Functional Responses ◽  
Perfused Rat Heart ◽  
Chronotropic Response ◽  
Isolated Perfused Rat Heart

During the β-adrenergic receptor (β-AR)-mediated stress response in the heart, the relations between functional responses and metabolism are ill defined, with the distinction between β1- and β2-AR subtypes creating further complexity. Specific outstanding questions include the temporal relation between inotropic and chronotropic responses and their metabolic correlates. We sought to elucidate the relative magnitudes and temporal dynamics of the response to β1- and β2-AR stimulation and the energy expenditure and bioenergetic state related to these responses in the isolated perfused rat heart. Inotropic [left ventricular developed pressure (LVDP) and dP/d t], chronotropic [heart rate (HR)], and metabolic responses were measured during β1- ( n = 9; agonist: norepinephrine) and β2- ( n = 9; agonist: zinterol) AR stimulation. Myocardial oxygen consumption (MV̇o2) was measured using fiber-optic oximetry, and high-energy phosphate levels and intracellular pH were measured using 31P NMR spectroscopy. A multiple-dose protocol was used, with near-maximal β-AR stimulation at the highest doses. In both β1 and β2 groups, there were dose-dependent increases in LVDP, dP/d t, HR, and MV̇o2. The inotropic response showed more rapid onset, washout, and variation during dose than did the chronotropic response and was closely correlated with MV̇o2. This suggests that the myocardial bioenergetic state is more closely related to the inotropic response than to the chronotropic response. In addition, β1-AR stimulation resulted in a greater magnitude and rate of onset of inotropic and MV̇o2 responses than did β2-AR stimulation during maximal stimulation. However, a similar decrease in intracellular energy charge was seen in the two groups, consistent with a greater rate of oxidative phosphorylation during β1- than during β2-AR stimulation.

The neuronal and extraneuronal uptake and deamination of 3H-(?)-phenylephrine in the perfused rat heart

1980 ◽  
Vol 314 (3) ◽  
pp. 237-247 ◽  
Author(s):  
A. Rawlow ◽  
H. Fleig ◽  
K. Kurahashi ◽  
U. Trendelenburg
Keyword(s):  
Rat Heart ◽  
Extraneuronal Uptake ◽  
Perfused Rat Heart
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