Demonstration by lectin cytochemistry of rod and cone photoreceptors in the lamprey retina

1989 ◽  
Vol 256 (2) ◽  
Author(s):  
Makoto Ishikawa ◽  
Hiroshi Watanabe ◽  
Yoshio Koike ◽  
Osamu Hisatomi ◽  
Fumio Tokunaga ◽  
...  
Keyword(s):  
Cone Photoreceptors ◽  
Lectin Cytochemistry ◽  
Rod And Cone Photoreceptors

Toward the generation of rod and cone photoreceptors from mouse, monkey and human embryonic stem cells

2008 ◽  
Vol 26 (2) ◽  
pp. 215-224 ◽  
Author(s):  
Fumitaka Osakada ◽  
Hanako Ikeda ◽  
Michiko Mandai ◽  
Takafumi Wataya ◽  
Kiichi Watanabe ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Cone Photoreceptors ◽  
Rod And Cone Photoreceptors

scholarly journals Lamin B1 and lamin B2 are long-lived proteins with distinct functions in retinal development

2016 ◽  
Vol 27 (12) ◽  
pp. 1928-1937 ◽  
Author(s):  
David Razafsky ◽  
Candace Ward ◽  
Chloe Potter ◽  
Wanqiu Zhu ◽  
Yunlu Xue ◽  
...  
Keyword(s):  
Nuclear Lamina ◽  
Building Blocks ◽  
Postnatal Life ◽  
Cone Photoreceptors ◽  
Obvious Effect ◽  
Lamin B1 ◽  
Embryonic Neurogenesis ◽  
And Function ◽  
Embryonic Retina ◽  
Rod And Cone Photoreceptors

Lamin B1 and lamin B2 are essential building blocks of the nuclear lamina, a filamentous meshwork lining the nucleoplasmic side of the inner nuclear membrane. Deficiencies in lamin B1 and lamin B2 impair neurodevelopment, but distinct functions for the two proteins in the development and homeostasis of the CNS have been elusive. Here we show that embryonic depletion of lamin B1 in retinal progenitors and postmitotic neurons affects nuclear integrity, leads to the collapse of the laminB2 meshwork, impairs neuronal survival, and markedly reduces the cellularity of adult retinas. In stark contrast, a deficiency of lamin B2 in the embryonic retina has no obvious effect on lamin B1 localization or nuclear integrity in embryonic retinas, suggesting that lamin B1, but not lamin B2, is strictly required for nucleokinesis during embryonic neurogenesis. However, the absence of lamin B2 prevents proper lamination of adult retinal neurons, impairs synaptogenesis, and reduces cone photoreceptor survival. We also show that lamin B1 and lamin B2 are extremely long-lived proteins in rod and cone photoreceptors. OF interest, a complete absence of both proteins during postnatal life has little or no effect on the survival and function of cone photoreceptors.

scholarly journals A Visual Pigment Expressed in Both Rod and Cone Photoreceptors

Neuron ◽  
2001 ◽  
Vol 32 (3) ◽  
pp. 451-461 ◽  
Author(s):  
Jian-xing Ma ◽  
Sergey Znoiko ◽  
Kashelle L. Othersen ◽  
James C. Ryan ◽  
Joydip Das ◽  
...  
Keyword(s):  
Visual Pigment ◽  
Cone Photoreceptors ◽  
Rod And Cone Photoreceptors

scholarly journals The Effect of Peripherin/rds Haploinsufficiency on Rod and Cone Photoreceptors

1997 ◽  
Vol 17 (21) ◽  
pp. 8118-8128 ◽  
Author(s):  
Tong Cheng ◽  
Neal S. Peachey ◽  
Shihong Li ◽  
Yoshinobu Goto ◽  
Yun Cao ◽  
...  
Keyword(s):  
Cone Photoreceptors ◽  
Rod And Cone Photoreceptors

scholarly journals Regulation of calcium homeostasis in the outer segments of rod and cone photoreceptors

2018 ◽  
Vol 67 ◽  
pp. 87-101 ◽  
Author(s):  
Frans Vinberg ◽  
Jeannie Chen ◽  
Vladimir J. Kefalov
Keyword(s):  
Calcium Homeostasis ◽  
Cone Photoreceptors ◽  
Outer Segments ◽  
Rod And Cone Photoreceptors

PRCD is Concentrated at the Base of Photoreceptor Outer Segments and is Involved in Outer Segment Disc Formation

2019 ◽  
Author(s):  
Gilad Allon ◽  
Irit Mann ◽  
Lital Remez ◽  
Elisabeth Sehn ◽  
Leah Rizel ◽  
...  
Keyword(s):  
Retinal Degeneration ◽  
Knockout Mice ◽  
Outer Segment ◽  
Mouse Retina ◽  
Cone Photoreceptors ◽  
Photoreceptor Outer Segment ◽  
Photoreceptor Outer Segments ◽  
Outer Segments ◽  
Rod And Cone Photoreceptors ◽  
Disc Formation

Abstract Mutations of the PRCD gene are associated with rod-cone degeneration in both dogs and humans. Prcd is expressed in the mouse eye as early as embryonic day 14. In the adult mouse retina PRCD is expressed in the outer segments of both rod and cone photoreceptors. Immunoelectron microscopy revealed that PRCD is located at the outer segment rim, and that it is highly concentrated at the base of the outer segment. Prcd-knockout mice present with progressive retinal degeneration, starting at 20 weeks of age and onwards. This process is reflected by a significant and progressive reduction of both scotopic and photopic electroretinographic responses, and by thinning of the retina, and specifically of the outer nuclear layer, indicating photoreceptor loss. Electron microscopy revealed severe damage to photoreceptor outer segments, which is associated with immigration of microglia cells to the Prcd-knockout retina, and accumulation of vesicles in the inter-photoreceptor space. Phagocytosis of photoreceptor outer segment discs by the retinal pigmented epithelium is severely reduced. Our data show that Prcd-knockout mice serve as a good model for retinal degeneration caused by PRCD mutations in humans. Our findings in these mice support the involvement of PRCD in outer segment disc formation of both rod and cone photoreceptors. Furthermore, they suggest a feedback mechanism which coordinates the rate of photoreceptor outer segment disc formation, shedding and phagocytosis. This study has important implications for understanding the function of PRCD in the retina, as well as for future development of treatment modalities for PRCD-deficiency in humans.

The Transduction Channels of Rod and Cone Photoreceptors

2005 ◽  
pp. 207-233
Author(s):  
U.B. Kaupp ◽  
D. Tränkner
Keyword(s):  
Cone Photoreceptors ◽  
Rod And Cone Photoreceptors
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