Carcinogenic effect of low doses of nitrosopyrrolidine administered in drinking water to Syrian golden hamsters

1982 ◽  
Vol 104 (1-2) ◽  
pp. 75-79 ◽  
Author(s):  
M. B. Ketkar ◽  
P. Schneider ◽  
R. Preussmann ◽  
Ch. Plass ◽  
U. Mohr
1983 ◽  
Vol 17 (3) ◽  
pp. 333-338 ◽  
Author(s):  
M.B. Ketkar ◽  
J. Holste ◽  
R. Preussmann ◽  
J. Althoff

1973 ◽  
Vol 51 (3) ◽  
pp. 1019-1027 ◽  
Author(s):  
Parviz Pour ◽  
Friedrich W. Krüger ◽  
Antonio Cardesa ◽  
Jürgen Althoff ◽  
Ulrich Mohr

1973 ◽  
Vol 50 (2) ◽  
pp. 323-329 ◽  
Author(s):  
J. Althoff ◽  
A. Cardesa ◽  
P. Pour ◽  
U. Mohr

1969 ◽  
Vol 55 (3) ◽  
pp. 127-135 ◽  
Author(s):  
Bela Toth ◽  
Philippe Shubik

Isonicotinic acid hydrazide (INH) was administered as a 0.3 % solution for 42 weeks intermittently and as a 0.2 and 0.1 % solutions continuously in the drinking water for the lifespan of adult Syrian golden hamsters. 0.3 % INH solution was found to be too toxic, therefore it had to be given periodically and finally the treatment had to be stopped, while 0.2 and 0.1 % INH solutions were relatively well tolerated during the entire life of the animals. The consumption of INH resulted in no detectable tumorigenic effect in the treated hamsters. It is concluded that the drug is apparently no carcinogenic in this species. In view of the fact that the tumor producing capability of INH was shown by numerous studies in mice, the matter of selective neoplastic response in the various species is discussed and emphasized.


1982 ◽  
Vol 44 (2) ◽  
pp. 267-274
Author(s):  
Takanori HARADA ◽  
Shigeto YAMASHIRO ◽  
Paul D. MEADE ◽  
Parvathi K. BASRUR ◽  
Keizo MAITA ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document