Tubuloglomerular feedback and autoregulation of glomerular filtration rate in Wistar-Kyoto spontaneously hypertensive rats

1978 ◽  
Vol 375 (3) ◽  
pp. 261-267 ◽  
Author(s):  
David W. Ploth ◽  
Herbert Dahlheim ◽  
Elfriede Schmidmeier ◽  
Monika Hermle ◽  
J�rgen Schnermann
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Spontaneously Hypertensive Rats ◽  
Filtration Rate ◽  
Tubuloglomerular Feedback ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Wistar Kyoto

Autoregulation of Total and Zonal Glomerular Filtration Rate in Spontaneously Hypertensive Rats with Mesangiolysis

1997 ◽  
Vol 20 (1) ◽  
pp. 11-17 ◽  
Author(s):  
Xuemei Wang ◽  
Knut Aukland ◽  
Leif Bostad ◽  
Bjarne M. Iversen
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Spontaneously Hypertensive Rats ◽  
Filtration Rate ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

Autoregulation of zonal glomerular filtration rate and renal blood flow in spontaneously hypertensive rats

1995 ◽  
Vol 269 (4) ◽  
pp. F515-F521 ◽  
Author(s):  
X. Wang ◽  
K. Aukland ◽  
J. Ofstad ◽  
B. M. Iversen
Keyword(s):  
Blood Flow ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Renal Blood Flow ◽  
Spontaneously Hypertensive Rats ◽  
Filtration Rate ◽  
Left Kidney ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Inner Cortex

Autoregulation of total and zonal glomerular filtration rate (GFR) in outer, middle and inner cortex was estimated in spontaneously hypertensive rats (SHR), from the tubular uptake of 125I-labeled aprotinin (125I-Ap), injected at control renal arterial pressure (RAP), and 131I-Ap, injected at reduced RAP in left kidney. Normotensive Wistar-Kyoto (WKY) rats were used as controls. Renal blood flow (RBF) autoregulation was reset to higher pressure levels in SHR. When RAP was lowered close to the lower pressure limit of RBF autoregulation, total GFR was reduced to 89.5 +/- 3.1 and 88.1 +/- 3.3% of control in 10- and 40-wk WKY and to 87.7 +/- 2.3 and 88.0 +/- 2.2% in 10- and 40-wk SHR. In WKY, the fall of GFR in the three cortical layers was not different during RAP reduction. In 10- and 40-wk-old SHR, however, GFR fell significantly less in inner than in middle and outer cortex (P < 0.05). We conclude that autoregulation of GFR is most efficient in the inner cortex of SHR. In all animals, GFR was less well autoregulated than RBF.

Abnormalities in glomerular function in rats developing spontaneous hypertension

1984 ◽  
Vol 246 (1) ◽  
pp. F12-F20 ◽  
Author(s):  
J. R. Dilley ◽  
C. T. Stier ◽  
W. J. Arendshorst
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Fluid Collection ◽  
Spontaneously Hypertensive ◽  
Fluid Delivery ◽  
Fluid Load ◽  
Single Nephron ◽  
Wistar Kyoto ◽  
Ultrafiltration Pressure

Clearance and micropuncture studies were conducted on 6-wk-old spontaneously hypertensive rats (SHR) of the Okamoto-Aoki strain and normotensive Wistar-Kyoto rats (WKY) under euvolemic conditions. Mean arterial pressure in SHR was elevated by 18 mmHg and their kidneys were vasoconstricted with reduced blood flow; resistances in preglomerular vessels and efferent arterioles were elevated 2.8 and 2 times, respectively, above WKY values. Whole kidney glomerular filtration rate (GFR) and single nephron glomerular filtration rate (SNGFR), based on fluid collection from either proximal or distal convolutions, were 25-30% lower in SHR. Fractional reabsorptions of fluid load by the proximal convoluted tubule (43%) and by the loop of Henle (52-55%) were similar in both groups. Accordingly, SHR exhibited less fluid delivery from the proximal convolution (8 vs. 12 nl/min) and to the distal convolution (3 vs. 5 nl/min). Glomerular dynamics in hypertensive and normotensive strains were characterized by filtration pressure disequilibrium. Estimated glomerular capillary pressure and mean effective ultrafiltration pressure were similar in SHR and WKY. SHR had a lower glomerular ultrafiltration coefficient than WKY (0.011 vs. 0.016 nl X s-1 X mmHg-1), which, combined with a lower glomerular plasma flow (41 vs. 73 nl/min), quantitatively accounted for the lower SNGFR in 6-wk-old SHR. These findings document important differences in renal function in young SHR compared with WKY that may participate in the development of hypertension.

Increased tubuloglomerular feedback activity in Milan hypertensive rats

1986 ◽  
Vol 250 (6) ◽  
pp. F967-F974 ◽  
Author(s):  
U. Boberg ◽  
A. E. Persson
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Tubuloglomerular Feedback ◽  
Spontaneously Hypertensive ◽  
Arterial Blood ◽  
Single Nephron ◽  
Flow Pressure ◽  
Normotensive Strain

Studies of whole-kidney function and micropuncture measurements in superficial nephrons were performed to investigate the role of the tubuloglomerular feedback (TGF) in the excretion of salt and water in hydropenic and volume-expanded rats of the spontaneously hypertensive Milan strain (MHS). The rats were 3.5-5 and 5-7 wk old, and age-matched animals from the Milan normotensive strain (MNS) served as controls. There was no difference in mean arterial blood pressure (Pa) between the 3.5- to 5-wk-old prehypertensive MHS (MHSp) and MNS rats, but the glomerular filtration rate (GFR) was higher in MHSp than in MNS [1.35 vs. 0.80 ml X min-1 X g kidney wt (KW)-1, P less than 0.01]. The distal single-nephron glomerular filtration rate (SNGFR) was also higher in MHSp than in MNS (28.6 vs. 20.2 nl X min-1 X g KW-1, P less than 0.05). TGF was determined from both stop-flow pressure response and proximal and distal SNGFR. It was found that MHSp exhibited essentially no TGF response. During development of hypertension 5- to 7-wk-old MHS (MHSd) had a higher Pa than MNS (120 vs. 98 mmHg, P less than 0.01). Normally GFR and SNGFR increase with age, and such was the case with MNS (0.8 to 1.02 ml X min-1 X g KW-1 and 20.2 to 23.4 nl X min-1 X g KW-1), but in MHSd there was a decrease in both GFR and SNGFR with age (1.35 to 1.10 ml X min-1 X g KW-1 and 28.3 to 18.3 nl X min-1 X g KW-1).(ABSTRACT TRUNCATED AT 250 WORDS)

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