Regional changes in brain angiotensin-converting enzyme activity in spontaneously hypertensive rats

1985 ◽  
Vol 100 (6) ◽  
pp. 1659-1661
Author(s):  
N. V. Komissarova ◽  
O. A. Gomazkov ◽  
V. V. Karpitskii ◽  
N. I. Vladimirova
Keyword(s):  
Enzyme Activity ◽  
Angiotensin Converting Enzyme ◽  
Spontaneously Hypertensive Rats ◽  
Converting Enzyme ◽  
Hypertensive Rats ◽  
Angiotensin Converting Enzyme Activity ◽  
Spontaneously Hypertensive

Effect of Sodium Intake on Angiotensin-Converting Enzyme Activity of Aorta in Rats

1981 ◽  
Vol 61 (2) ◽  
pp. 249-251 ◽  
Author(s):  
Kenji Mizuno ◽  
Shunichi Hata ◽  
Soitsu Fukuchi
Keyword(s):  
Enzyme Activity ◽  
Angiotensin Converting Enzyme ◽  
Spontaneously Hypertensive Rats ◽  
Sodium Intake ◽  
Subcellular Fractions ◽  
Supernatant Fraction ◽  
Converting Enzyme ◽  
Hypertensive Rats ◽  
Angiotensin Converting Enzyme Activity ◽  
Spontaneously Hypertensive

1. The effect of sodium intake on angiotensin-converting enzyme activity in subcellular fractions of aorta (homogenate, mitochondria, microsomes and supernatant) was studied in normotensive and spontaneously hypertensive rats. 2. Angiotensin-converting enzyme activity was extremely high in the supernatant fraction in normotensive and spontaneously hypertensive rats. 3. Total converting enzyme activity in spontaneously hypertensive rats was 34% higher than that in normotensive rats. 4. Increased sodium intake resulted in a marked reduction, almost to zero, of converting enzyme activity in each fraction of aorta in normotensive and spontaneously hypertensive rats. 5. Converting enzyme, widely distributed in subcellular fractions of the aorta, may play a possible rôle in the local control of vascular tone. It is likely that sodium intake inhibits production of the enzyme in vascular tissue.

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