Application of the axial dispersion model of hepatic drug elimination to the kinetics of diazepam in the isolated perfused rat liver

1992 ◽  
Vol 20 (2) ◽  
pp. 171-193 ◽  
Author(s):  
Juan M. Diaz-Garcia ◽  
Allan M. Evans ◽  
Malcolm Rowland
Keyword(s):  
Rat Liver ◽  
Dispersion Model ◽  
Axial Dispersion ◽  
Isolated Perfused Rat Liver ◽  
Drug Elimination ◽  
Perfused Rat Liver ◽  
Hepatic Drug ◽  
Axial Dispersion Model ◽  
Kinetics Of

Kinetics of galactosyl-neoglycoalbumin uptake after continuous infusion into the isolated perfused rat liver

1990 ◽  
Vol 18 (2) ◽  
pp. 292-293 ◽  
Author(s):  
STEPHEN GORE ◽  
ANTHONY I. MORRIS ◽  
IAN T. GILMORE ◽  
DAVID BILLINGTON
Keyword(s):  
Continuous Infusion ◽  
Rat Liver ◽  
Isolated Perfused Rat Liver ◽  
Perfused Rat Liver ◽  
Kinetics Of

Kinetics of Gadobenate Dimeglumine in Isolated Perfused Rat Liver: MR Imaging Evaluation

Radiology ◽  
2003 ◽  
Vol 229 (1) ◽  
pp. 119-125 ◽  
Author(s):  
Catherine M. Pastor ◽  
Corinne Planchamp ◽  
Sibylle Pochon ◽  
Vito Lorusso ◽  
Xavier Montet ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Rat Liver ◽  
Gadobenate Dimeglumine ◽  
Isolated Perfused Rat Liver ◽  
Perfused Rat Liver ◽  
Imaging Evaluation ◽  
Kinetics Of

Kinetics of Distribution of D2O and Antipyrine in Isolated Perfused Rat Liver

1958 ◽  
Vol 192 (3) ◽  
pp. 531-537 ◽  
Author(s):  
Alan M. Thompson ◽  
H. Mead Cavert ◽  
Nathan Lifson
Keyword(s):  
Rat Liver ◽  
Early Period ◽  
Tissue Perfusion ◽  
Isolated Perfused Rat Liver ◽  
Perfused Rat Liver ◽  
Rate Of Increase ◽  
The Difference ◽  
Rat Livers ◽  
Kinetics Of

Isolated rat livers were perfused via the portal vein with a blood-Ringer mixture containing a constant inflow concentration of D2O and, in some cases, antipyrine. The rate of increase of outflow concentration was studied, comparisons being made between D2O, antipyrine and a theoretical outflow curve based on completely flow-limited distribution. The effect of flow rate on the deviation of D2O from theoretical was also studied. The results indicate that exchange of D2O and antipyrine between blood and tissue in the perfused rat liver is extremely rapid relative to the rate of blood supply of these substances to the organ, even at flows several times that occurring in vivo. In the average experiment the average D2O concentration in the liver during the early period of the perfusion was about 90% of the mixed venous concentration. The factors responsible for the failure of D2O to distribute maximally, particularly tissue perfusion heterogeneity and diffusion limitation, are discussed. Although quantitation of the difference is difficult, antipyrine appears to distribute somewhat more rapidly than D2O due to its greater solubility in cell membranes.

Kinetics of cadmium transport in the isolated perfused rat liver

1976 ◽  
Vol 38 (3) ◽  
pp. 583-593 ◽  
Author(s):  
John M. Frazier ◽  
Beverly Stern Kingsley
Keyword(s):  
Rat Liver ◽  
Isolated Perfused Rat Liver ◽  
Perfused Rat Liver ◽  
Cadmium Transport ◽  
Kinetics Of
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