Disposition kinetics, urinary excretion and dosage regimen of kanamycin in buffalo calves following single intravenous administration

1993 ◽  
Vol 17 (3) ◽  
pp. 219-225
Author(s):  
S. Rampal ◽  
A. K. Srivastava ◽  
R. K. Chaudhary
Keyword(s):  
Urinary Excretion ◽  
Intravenous Administration ◽  
Dosage Regimen ◽  
Buffalo Calves ◽  
Disposition Kinetics ◽  
Single Intravenous Administration

Pharmacokinetics of lincomycin following single intravenous administration in buffalo calves

2014 ◽  
Vol 46 (6) ◽  
pp. 1099-1102 ◽  
Author(s):  
Sreedharan Sreeshitha Gouri ◽  
Dinakaran Venkatachalam ◽  
Vinod Kumar Dumka
Keyword(s):  
Intravenous Administration ◽  
Buffalo Calves ◽  
Single Intravenous Administration

N -ACETYL-CYSTEINE REDUCES HOMOCYSTEINE PLASMA LEVELS AFTER SINGLE INTRAVENOUS ADMINISTRATION BY INCREASING THIOLS URINARY EXCRETION

1999 ◽  
Vol 40 (4) ◽  
pp. 345-350 ◽  
Author(s):  
PAOLO VENTURA ◽  
ROSSANA PANINI ◽  
MARIA CRISTINA PASINI, ◽  
GABRIELLA SCARPETTA ◽  
GIANFRANCO SALVIOLI
Keyword(s):  
Urinary Excretion ◽  
Intravenous Administration ◽  
Plasma Levels ◽  
Acetyl Cysteine ◽  
Single Intravenous Administration

scholarly journals Disposition Kinetics and Dosage Regimen of Ceftriaxone in Crossbred Calves (Short Communication)

1999 ◽  
Vol 47 (2) ◽  
pp. 243-246 ◽  
Author(s):  
Bindu Johal ◽  
A. K. Srivastava
Keyword(s):  
Dosage Regimen ◽  
Peak Plasma ◽  
Binding Capacity ◽  
Volume Of Distribution ◽  
Dissociation Rate ◽  
Peak Plasma Level ◽  
Disposition Kinetics ◽  
Elimination Half ◽  
Total Body ◽  
Single Intravenous Administration

Disposition kinetics and urinary excretion of ceftriaxone were investigated in healthy crossbred calves after its single intravenous administration (10 mg kg–1). Based on kinetic parameters, an appropriate dosage regimen of ceftriaxone in calves was calculated. The peak plasma level of ceftriaxone at 1 min was 84.0 ± 1.55 μg ml–1 which declined to 0.43 ± 0.05 μg ml–1 at 8 h. The value of elimination half-life (t1/2α), volume of distribution Vd (area) and total body clearance (ClB) were 4.39 ± 0.63 h, 1.91 ± 0.19 L kg–1 and 0.31 ± 0.01 L kg–1 h–1, respectively. Approximately 41 per cent of total administered drug was recovered in the urine within 24 h of its administration. The plasma protein binding of ceftriaxone was found to be concentration dependent with an overall mean of 38.55 per cent. The binding capacity of ceftriaxone to plasma proteins and the dissociation rate constant of protein-drug complex were 20.1 × 10–8 ± 18.4 × 10–8 mole g–1 and 1.07 × 10–6 ± 0.52 × 10–6 mole, respectively. An appropriate intravenous dosage regimen of ceftriaxone in cattle would be 12 mg kg–1 repeated at 24 h.

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