Detection of alpha-1-antichymotrypsin in hepatocellular carcinoma tissue

1991 ◽  
Vol 3 (3) ◽  
pp. 53-56
Author(s):  
Xuefeng Jing ◽  
Peiliang Yu
Keyword(s):  
Hepatocellular Carcinoma ◽  
Carcinoma Tissue ◽  
Hepatocellular Carcinoma Tissue

Organization and expression of hepatitis B sequences cloned from hepatocellular carcinoma tissue DNA

1982 ◽  
Vol 20 (3) ◽  
pp. 293-301 ◽  
Author(s):  
Anne Dejean ◽  
Guido Carloni ◽  
Christian Bréchot ◽  
Pierre Tiollais ◽  
Simon Wain-Hobson
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B ◽  
Carcinoma Tissue ◽  
Hepatocellular Carcinoma Tissue

Methylation of promoter and expression silencing of GPX3 gene in hepatocellular carcinoma tissue

2015 ◽  
Vol 39 (2) ◽  
pp. 198-204 ◽  
Author(s):  
Shengli Cao ◽  
Bing Yan ◽  
Yantao Lu ◽  
Gong Zhang ◽  
Jie Li ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Carcinoma Tissue ◽  
Hepatocellular Carcinoma Tissue

Proteomic profiling in microdissected hepatocellular carcinoma tissue using ProteinChip® technology

2004 ◽  
Author(s):  
Christian Melle ◽  
Roland Kaufmann ◽  
Merten Hommann ◽  
Annett Bleul ◽  
Dominik Driesch ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Proteomic Profiling ◽  
Carcinoma Tissue ◽  
Hepatocellular Carcinoma Tissue

scholarly journals Expression of a Secretory Protein C1qTNF6, a C1qTNF Family Member, in Hepatocellular Carcinoma

2011 ◽  
Vol 34 (3) ◽  
pp. 113-121 ◽  
Author(s):  
Tamotsu Takeuchi ◽  
Yoshihiro Adachi ◽  
Tomoko Nagayama
Keyword(s):  
Hepatocellular Carcinoma ◽  
Endothelial Cells ◽  
Carcinoma Cells ◽  
Akt Pathway ◽  
Hepatocellular Carcinoma Cells ◽  
Carcinoma Tissue ◽  
Hepatocellular Carcinomas ◽  
Tumor Neovascularization ◽  
Tissue Specimens ◽  
Hepatocellular Carcinoma Tissue

Background: Recent studies have revealed that the adiponectin-associated protein belonging to the C1qTNF family mediates various biological processes. However, the pathobiological property of C1qTNF6 in carcinogenesis remains unclear. Here, we investigated the expression status of C1qTNF6 in human hepatocellular carcinomas and subsequently attempted to determine the role of C1qTNF6 in tumor neovascularization. Methods: Immunohistochemical staining was performed to evaluate the expression of C1qTNF6 in hepatocellular carcinoma tissue specimens. Various eukaryotic recombinant C1qTNF6 proteins were prepared to ask whether C1qTNF6 could activate Akt pathway in human liver sinusoidal microvascular endothelial cells. Xenograft assay was carried out to know the effect of C1qTNF6 on tumor neovascularization. Results: C1qTNF6 was not immunohistochemically detected in any non-cancerous liver tissues but was detected in 21 of 30 hepatocellular carcinoma tissue specimens. C1qTNF6 was not uniformly distributed but rather focally localized in hepatocellular carcinoma cells. Interestingly, it was also localized on the tumor endothelial cells, which were in close proximity of C1qTNF6-expressing hepatocellular carcinoma cells. Eukaryotic recombinant C1qTNF6 increased the level of active phosphorylated Akt molecules in cultured vascular endothelial cells via its C-terminal C1q domain. In the xenograft assay, enforced expression of C1qTNF6 markedly reduced the central hypovascular necrosis areas of the transplanted HepG2 hepatocellular carcinoma cells. Conclusion: These results indicate that C1qTNF6 is overexpressed and possibly contributes to tumor angiogenesis by activating the Akt pathway in many hepatocellular carcinomas.

Increased Golgi protein 73 expression in hepatocellular carcinoma tissue correlates with tumor aggression but not survival

2011 ◽  
Vol 26 (7) ◽  
pp. 1207-1212 ◽  
Author(s):  
Yongliang Sun ◽  
Huayu Yang ◽  
Yilei Mao ◽  
Haifeng Xu ◽  
Jinchun Zhang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Carcinoma Tissue ◽  
Golgi Protein ◽  
Hepatocellular Carcinoma Tissue
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