Chromosomal Abnormalities Affect the Surgical Outcome in Infants with Hypoplastic Left Heart Syndrome: A Large Cohort Analysis

2017 ◽  
Vol 39 (1) ◽  
pp. 11-18 ◽  
Author(s):  
Dala Zakaria ◽  
Xinyu Tang ◽  
Rupal Bhakta ◽  
Nahed O. ElHassan ◽  
Parthak Prodhan
Keyword(s):  
Hypoplastic Left Heart Syndrome ◽  
Surgical Outcome ◽  
Chromosomal Abnormalities ◽  
Cohort Analysis ◽  
Large Cohort ◽  
Left Heart ◽  
Hypoplastic Left Heart ◽  
Left Heart Syndrome

Genetic Disorders and Major Extracardiac Anomalies Associated With the Hypoplastic Left Heart Syndrome

PEDIATRICS ◽  
1988 ◽  
Vol 82 (5) ◽  
pp. 698-706 ◽  
Author(s):  
Marvin Natowicz ◽  
Jane Chatten ◽  
Robert Clancy ◽  
Katrina Conard ◽  
Tracy Glauser ◽  
...  
Keyword(s):  
Hypoplastic Left Heart Syndrome ◽  
Chromosomal Abnormalities ◽  
Genetic Disorders ◽  
Genetic Disorder ◽  
Single Gene ◽  
Left Heart ◽  
Hypoplastic Left Heart ◽  
Gene Defects ◽  
Insulin Dependent Diabetic ◽  
Left Heart Syndrome

All pediatric autopsies of patients with hypoplastic left heart syndrome seen during an 11-year interval were reviewed to determine the frequency of underlying chromosomal and single-gene defects and idiopathic major extracardiac anomalies associated with this common, lethal congenital heart abnormality. Of 83 patients identified, nine had underlying chromosomal abnormalities, four had single-gene defects, ten had one or more major extracardiac anomalies without an identifiable chromosomal or mendelian disorder, and two were infants of insulin-dependent diabetic mothers. Overall, 23 patients (28%) had a genetic disorder and/or major extracardiac anomaly. The substantial prevalence of genetic causes of and major extracardiac anomalies associated with hypoplastic left heart syndrome underscores the need for a detailed genetic evaluation for all patients with hypoplastic left heart syndrome.

scholarly journals Improved Surgical Outcome After Fetal Diagnosis of Hypoplastic Left Heart Syndrome

Circulation ◽  
2001 ◽  
Vol 103 (9) ◽  
pp. 1269-1273 ◽  
Author(s):  
Wayne Tworetzky ◽  
Doff B. McElhinney ◽  
V. Mohan Reddy ◽  
Michael M. Brook ◽  
Frank L. Hanley ◽  
...  
Keyword(s):  
Hypoplastic Left Heart Syndrome ◽  
Surgical Outcome ◽  
Left Heart ◽  
Hypoplastic Left Heart ◽  
Fetal Diagnosis ◽  
Left Heart Syndrome

Surgical outcome of hypoplastic left heart syndrome with intact atrial septum

2015 ◽  
Vol 23 (9) ◽  
pp. 1034-1038 ◽  
Author(s):  
Sadahiko Arai ◽  
Yasuhiro Fujii ◽  
Yasuhiro Kotani ◽  
Yosuke Kuroko ◽  
Shingo Kasahara ◽  
...  
Keyword(s):  
Hypoplastic Left Heart Syndrome ◽  
Surgical Outcome ◽  
Atrial Septum ◽  
Left Heart ◽  
Hypoplastic Left Heart ◽  
Intact Atrial Septum ◽  
Left Heart Syndrome

scholarly journals Surgical outcome for patients with the mitral stenosis–aortic atresia variant of hypoplastic left heart syndrome

2008 ◽  
Vol 135 (2) ◽  
pp. 339-346 ◽  
Author(s):  
Vladimiro L. Vida ◽  
Emile A. Bacha ◽  
Alesandro Larrazabal ◽  
Kimberly Gauvreau ◽  
Adam L. Dorfman ◽  
...  
Keyword(s):  
Hypoplastic Left Heart Syndrome ◽  
Surgical Outcome ◽  
Mitral Stenosis ◽  
Left Heart ◽  
Hypoplastic Left Heart ◽  
Aortic Atresia ◽  
Left Heart Syndrome

Improved surgical outcome after fetal diagnosis of hypoplastic left heart syndrome

2001 ◽  
Vol 10 (5) ◽  
pp. 89
Author(s):  
W Tworetzky ◽  
D.B McElhinney ◽  
M Reddy ◽  
M.M Brook ◽  
F.L Hanley ◽  
...  
Keyword(s):  
Hypoplastic Left Heart Syndrome ◽  
Surgical Outcome ◽  
Left Heart ◽  
Hypoplastic Left Heart ◽  
Fetal Diagnosis ◽  
Left Heart Syndrome

scholarly journals A Rare Combination of Chromosomal Abnormalities in an Infant With Turner Syndrome and Hypoplastic Left Heart Syndrome

Cureus ◽  
2021 ◽  
Author(s):  
Roya Huseynova ◽  
Latifa Bin Mahmoud ◽  
Abduljabbbar Alshenqiti ◽  
Khalid Alomran ◽  
Nabeel Alodaidan ◽  
...  
Keyword(s):  
Turner Syndrome ◽  
Hypoplastic Left Heart Syndrome ◽  
Chromosomal Abnormalities ◽  
Left Heart ◽  
Hypoplastic Left Heart ◽  
Rare Combination ◽  
Left Heart Syndrome
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