Efflux identification and engineering for ansamitocin P-3 production in Actinosynnema pretiosum

2021 ◽  
Author(s):  
Xinran Wang ◽  
Jianhua Wei ◽  
Yifan Xiao ◽  
Shuhui Luan ◽  
Xinjuan Ning ◽  
...  
Keyword(s):  
Actinosynnema Pretiosum

Nomenclature Abstract for Actinosynnema pretiosum pretiosum Hasegawa et al. 1983.

2003 ◽  
Author(s):  
Charles Thomas Parker ◽  
Nicole Danielle Osier ◽  
George M Garrity
Keyword(s):  
Actinosynnema Pretiosum

Metabolomics analysis of Actinosynnema pretiosum with improved AP-3 production by enhancing UDP-glucose biosynthesis

2020 ◽  
Vol 130 (1) ◽  
pp. 36-47
Author(s):  
Ting Liu ◽  
Ziwen Jin ◽  
Ziwei Wang ◽  
Jun Chen ◽  
Liu-Jing Wei ◽  
...  
Keyword(s):  
Actinosynnema Pretiosum ◽  
Metabolomics Analysis

scholarly journals Unprecedented deoxygenation at C-7 of the ansamitocin core during mutasynthetic biotransformations

2012 ◽  
Vol 8 ◽  
pp. 861-869 ◽  
Author(s):  
Tobias Knobloch ◽  
Gerald Dräger ◽  
Wera Collisi ◽  
Florenz Sasse ◽  
Andreas Kirschning
Keyword(s):  
Antiproliferative Activity ◽  
Side Chain ◽  
Actinosynnema Pretiosum

We describe the unprecedented formation of six ansamitocin derivatives that are deoxygenated at C-7 of the ansamitocin core, obtained during fermentation experiments by employing a variety of Actinosynnema pretiosum mutants and mutasynthetic approaches. We suggest that the formation of these derivatives is based on elimination at C-7/C-8 followed by reduction(s) of the intermediate enone. In bioactivity tests, only ansamitocin derivatives bearing an ester side chain at C-3 showed strong antiproliferative activity.

Determination of the Cryptic Stereochemistry of the First PKS Chain-Extension Step in Ansamitocin Biosynthesis by Actinosynnema pretiosum

ChemBioChem ◽  
2006 ◽  
Vol 7 (8) ◽  
pp. 1221-1225 ◽  
Author(s):  
Takaaki Kubota ◽  
Marco Brünjes ◽  
Thomas Frenzel ◽  
Jun Xu ◽  
Andreas Kirschning ◽  
...  
Keyword(s):  
Chain Extension ◽  
Actinosynnema Pretiosum

Two novel ansamitocin analogs from Actinosynnema pretiosum

2012 ◽  
Vol 27 (17) ◽  
pp. 1532-1536 ◽  
Author(s):  
Siyu-Mao ◽  
Hong-Chen ◽  
Li-Chen ◽  
Chuanxi-Wang ◽  
Wei-Jia ◽  
...  
Keyword(s):  
Actinosynnema Pretiosum
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