Liver function correlates with liver-to-portal vein contrast ratio during the hepatobiliary phase with Gd-EOB-DTPA-enhanced MR at 3 Tesla

2018 ◽  
Vol 43 (9) ◽  
pp. 2262-2269 ◽  
Author(s):  
Weiguo Zhang ◽  
Xiao Wang ◽  
Youhan Miao ◽  
Chunhong Hu ◽  
Weifeng Zhao
Keyword(s):  
Liver Function ◽  
Portal Vein ◽  
Contrast Ratio ◽  
3 Tesla ◽  
Hepatobiliary Phase

scholarly journals Evaluation of liver function using liver parenchyma, spleen and portal vein signal intensities during the hepatobiliary phase in Gd-EOB-DTPA-enhanced MRI

2020 ◽  
Author(s):  
Ming Yang ◽  
Yue Zhang ◽  
Wenlu Zhao ◽  
Wen Cheng ◽  
Han Wang ◽  
...  
Keyword(s):  
Liver Function ◽  
Portal Vein ◽  
Contrast Ratio ◽  
Liver Parenchyma ◽  
International Normalized Ratio ◽  
Imaging Biomarkers ◽  
Hepatobiliary Phase ◽  
Enhanced Mri ◽  
Pugh Class ◽  
Class C

Abstract Background: Previous studies have used signal intensity (SI) to reflect liver function. However, few studies have evaluated liver function via the portal vein. Regarding the SI of the liver, spleen, and portal vein, no study has indicated which can best reflect liver function. Therefore, the aim of this study is to investigate whether these parameters can evaluate liver function in patients with cirrhosis and determine which is the best parameter.Methods: 120 patients with normal livers (n = 41) or Child–Pugh class A (n = 50), B (n = 21) or C (n = 8) disease who had undergone Gd-EOB-DTPA-enhanced MRI were retrospectively reviewed. Comparisons of the MRI data (liver parenchyma SI, portal vein SI, and spleen SI and liver-to-portal vein contrast ratio (LPC), liver-to-spleen contrast ratio (LSC), and portal vein-to-spleen contrast ratio (PSC)) in the 15-min hepatobiliary phase images were performed among the groups, and the correlations among the liver function parameters (total bilirubin, direct bilirubin, indirect bilirubin, aspartate aminotransferase, alanine aminotransferase, albumin, creatinine, platelet count, prothrombin time and international normalized ratio), liver function scores and MRI data were also quantitatively analysed.Results: Significant differences were observed in the liver parenchyma SI, LPC and LSC among the groups. These values all decreased gradually from normal livers to Child–Pugh class C cirrhotic livers (P < 0.001). The portal vein SI constantly and slightly increased from normal livers to Child–Pugh class C cirrhotic livers, but no differences were found among the groups in the portal vein SI and PSC (P > 0.05). LPC showed a stronger correlation with the Child–Pugh score and MELD score than LSC and the liver parenchyma SI. The order of the AUCs of these parameters, from largest to smallest, was as follows: LPC, LSC, and liver parenchyma SI (P > 0.05).Conclusion: The liver parenchyma SI, LSC and LPC may be used as alternative imaging biomarkers to assess liver function, while the portal vein SI and PSC do not reflect liver function. Furthermore, LPC values can more effectively distinguish severity among patients with cirrhosis than the liver parenchyma SI and LSC.

scholarly journals Evaluation of the liver function by the liver parenchyma, spleen and portal vein signal intensity during the hepatobiliary phase with Gd-EOB-DTPA-enhanced MRI

2020 ◽  
Author(s):  
Ming Yang ◽  
Yue Zhang ◽  
Wenlu Zhao ◽  
Wen Cheng ◽  
Han Wang ◽  
...  
Keyword(s):  
Liver Function ◽  
Mr Imaging ◽  
Portal Vein ◽  
Signal Intensity ◽  
Contrast Ratio ◽  
Liver Parenchyma ◽  
Hepatobiliary Phase ◽  
Unified Study ◽  
Pugh Class ◽  
Class C

Abstract Background: Assessment of liver function is essential for the treatment and prognosis of patients with cirrhosis, previous studies used signal intensity of hepatobiliary phase to reflect liver function on gadolinium-ethoxybenzyl-diethylenetriamine penta-acetic acid (Gd-EOB-DTPA)-enhanced MR imaging. But none of these studies has conducted a unified study on liver, spleen and portal vein. Thus, the aim of this study is to conduct a unified study, investigate whether they can be used to evaluate the liver function in patients with cirrhosis and find out which one is better.Methods: A total of 120 patients with normal (n = 41), Child–Pugh class A (n = 50), B (n = 21) or C (n = 8) who underwent Gd-EOB-DTPA-enhanced 3 Tesla MR imaging were retrospectively reviewed. Comparison of MRI date (signal intensity of liver parenchyma, portal vein, spleen, and liver-to-portal vein [LPC], liver-to-spleen [LSC], portal vein-to-spleen [PSC] contrast ratio) on hepatobiliary phase 15 min among groups, and liver function parameters was quantitatively analyzed as well.Results: A significantly difference was observed between the SI of liver parenchyma, LPC and LSC among groups (P < 0.001). They all decreased gradually from normal to cirrhotic livers with Child–Pugh class C (P < 0.001). The SI of portal vein constantly and slightly increased from normal to Child–Pugh class C, but there were not differences among the groups (P > 0.05). LPC is more correlated with Child-Pugh score or MELD score than LSC and liver parenchyma SI. A receiver operating characteristic curve analysis revealed that the AUC in order from the large to the small are: LPC, LSC, and the liver parenchyma SI (0.892, 0.889, 0.836), but the differences of AUCs among them were not significant.Conclusion: Liver parenchyma SI, LSC and LPC might be used as alternatives imaging biomarker for assessing liver function. Furthermore, LPC values can more efficaciously indicate the severity between patients with cirrhosis than SI of liver parenchyma and LSC. Although the portal vein signal shows a certain upward trend, it could not be used to reflect liver function.

scholarly journals Evaluation of liver function using liver parenchyma, spleen and portal vein signal intensities during the hepatobiliary phase in Gd-EOB-D TPA-enhanced MRI

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Ming Yang ◽  
Yue Zhang ◽  
Wenlu Zhao ◽  
Wen Cheng ◽  
Han Wang ◽  
...  
Keyword(s):  
Liver Function ◽  
Portal Vein ◽  
Contrast Ratio ◽  
Liver Parenchyma ◽  
International Normalized Ratio ◽  
Imaging Biomarkers ◽  
Hepatobiliary Phase ◽  
Enhanced Mri ◽  
Pugh Class ◽  
Class C

Abstract Background Previous studies have used signal intensity (SI) to reflect liver function. However, few studies have evaluated liver function via the portal vein. Regarding the SI of the liver, spleen, and portal vein, no study has indicated which can best reflect liver function. Therefore, the aim of this study is to investigate whether these parameters can evaluate liver function in patients with cirrhosis and determine which is the best parameter. Methods 120 patients with normal livers (n = 41) or Child–Pugh class A (n = 50), B (n = 21) or C (n = 8) disease who had undergone Gd-EOB-DTPA-enhanced MRI were retrospectively reviewed. Comparisons of the MRI data (liver parenchyma SI, portal vein SI, and spleen SI and liver-to-portal vein contrast ratio (LPC), liver-to-spleen contrast ratio (LSC), and portal vein-to-spleen contrast ratio (PSC)) in the 15-min hepatobiliary phase images were performed among the groups, and the correlations among the liver function parameters (total bilirubin, direct bilirubin, indirect bilirubin, aspartate aminotransferase, alanine aminotransferase, albumin, creatinine, platelet count, prothrombin time and international normalized ratio), liver function scores and MRI data were also quantitatively analysed. Results Significant differences were observed in the liver parenchyma SI, LPC and LSC among the groups. These values all decreased gradually from normal livers to Child–Pugh class C cirrhotic livers (P < 0.001). The portal vein SI constantly and slightly increased from normal livers to Child–Pugh class C cirrhotic livers, but no differences were found among the groups in the portal vein SI and PSC (P > 0.05). LPC showed a stronger correlation with the Child–Pugh score and MELD score than LSC and the liver parenchyma SI. The order of the AUCs of these parameters, from largest to smallest, was as follows: LPC, LSC, and liver parenchyma SI (P > 0.05). Conclusion The liver parenchyma SI, LSC and LPC may be used as alternative imaging biomarkers to assess liver function, while the portal vein SI and PSC do not reflect liver function. Furthermore, LPC values can more effectively distinguish severity among patients with cirrhosis than the liver parenchyma SI and LSC.

scholarly journals Evaluation of the liver function by the liver parenchyma, spleen and portal vein signal intensity during the hepatobiliary phase in Gd-EOB-DTPA-enhanced MRI

2020 ◽  
Author(s):  
Ming Yang ◽  
Yue Zhang ◽  
Wenlu Zhao ◽  
Wen Cheng ◽  
Han Wang ◽  
...  
Keyword(s):  
Liver Function ◽  
Portal Vein ◽  
Signal Intensity ◽  
Liver Parenchyma ◽  
International Normalized Ratio ◽  
Imaging Biomarkers ◽  
Hepatobiliary Phase ◽  
Enhanced Mri ◽  
Pugh Class ◽  
Class C

Abstract Background: Previous studies used the signal intensity (SI) to reflect liver function. However, there are still few studies on the assessment of liver function via the portal vein, and no study has pointed out that in terms of SI (liver, spleen, portal vein), which one can better reflect liver function. Therefore, the aim of this study is to investigate whether these parameters can be used to evaluate liver function in patients with cirrhosis and determine which parameter is best.Methods: A total of 120 patients with normal livers (n = 41) or Child–Pugh class A (n = 50), B (n = 21) or C (n = 8) disease who underwent Gd-EOB-DTPA-enhanced MRI were retrospectively reviewed. Comparisons of the SI of the liver parenchyma, portal vein, and spleen and liver-to-portal vein (LPC), liver-to-spleen (LSC), and portal vein-to-spleen (PSC) contrast ratios on the 15-min hepatobiliary phase images were performed among groups, and the correlations among liver function parameters (total bilirubin, direct bilirubin, indirect bilirubin, aspartate aminotransferase, alanine aminotransferase, albumin, creatinine, platelet count, prothrombin time and international normalized ratio), liver function scores and MRI date were also quantitatively analyzed.Results: Significant differences were observed in the SI of the liver parenchyma, LPC and LSC among groups. These values all decreased gradually from normal livers to Child–Pugh class C cirrhotic livers (P < 0.001). The SI of the portal vein constantly and slightly increased from normal livers to Child–Pugh class C cirrhotic livers, but there were no differences among groups in portal vein signal and PSC (P > 0.05). LPC had a stronger correlation with Child-Pugh score and MELD score than LSC and liver parenchyma SI. The order of the AUCs of these parameters, from largest to smallest, was as follows: LPC, LSC, and liver parenchyma SI (P > 0.05).Conclusion: Liver parenchyma SI, LSC and LPC may be used as alternative imaging biomarkers for assessing liver function, while the portal vein signal and PSC could not reflect liver function. Furthermore, LPC values can more effectively distinguish severity among patients with cirrhosis than liver parenchyma SI and LSC.

Assessing liver function by liver enhancement during the hepatobiliary phase with Gd-EOB-DTPA-enhanced MRI at 3 Tesla

2014 ◽  
Vol 24 (5) ◽  
pp. 1013-1019 ◽  
Author(s):  
N. Verloh ◽  
M. Haimerl ◽  
F. Zeman ◽  
M. Schlabeck ◽  
A. Barreiros ◽  
...  
Keyword(s):  
Liver Function ◽  
3 Tesla ◽  
Hepatobiliary Phase ◽  
Enhanced Mri

Assessment of the cut-off value of quantitative liver–portal vein contrast ratio in the hepatobiliary phase of liver MRI

2021 ◽  
Author(s):  
Y. Takatsu ◽  
M. Nakamura ◽  
T. Shiozaki ◽  
S. Narukami ◽  
D. Yoshimaru ◽  
...  
Keyword(s):  
Portal Vein ◽  
Contrast Ratio ◽  
Hepatobiliary Phase ◽  
Liver Mri

Safety and efficacy of right portal vein embolization in patients with prior left lateral liver resection

2021 ◽  
pp. 028418512110141
Author(s):  
Vincent Van den Bosch ◽  
Federico Pedersoli ◽  
Sebastian Keil ◽  
Ulf P Neumann ◽  
Christiane K Kuhl ◽  
...  
Keyword(s):  
Liver Function ◽  
Portal Vein ◽  
Portal Vein Embolization ◽  
Liver Volume ◽  
Liver Function Tests ◽  
Complete Resection ◽  
Liver Remnant ◽  
Total Liver Volume ◽  
Function Tests ◽  
Staged Hepatectomy

Background In patients with bilobar metastatic liver disease, surgical clearance of both liver lobes may be achieved through multiple-stage liver resections. For patients with extensive disease, a major two-staged hepatectomy consisting of resection of liver segments II and III before right-sided portal vein embolization (PVE) and resection of segments V–VIII may be performed, leaving only segments IV ± I as the liver remnant. Purpose To describe the outcome following right-sided PVE after prior complete resection of liver segments II and III. Material and Methods In this retrospective study, 15 patients (mean age = 60.4 ± 9.3 years) with liver metastases from colorectal cancer (n = 14) and uveal melanoma (n = 1) who were scheduled to undergo a major two-stage hepatectomy, were included. Total liver volume (TLV) and volume of the future liver remnant (FLR) were measured on pre- and postinterventional computed tomography (CT) scans, and standardized FLR volumes (ratio FLR/TLV) were calculated. Patient data were retrospectively analyzed regarding peri- and postinterventional complications, with special emphasis on liver function tests. Results The mean standardized post-PVE FLR volume was 26.9% ± 6.4% and no patient developed hepatic insufficiency after the PVE. Based on FLR hypertrophy and liver function tests, all but one patient were considered eligible for the subsequent right-sided hepatectomy. However, due to local tumor progression, only 9/15 patients eventually proceeded to the second stage of surgery.   Conclusion Right-sided PVE was safe and efficacious in this cohort of patients who had previously undergone a complete resection of liver segments II and III as part of a major staged hepatectomy pathway leaving only segments IV(±I) as the FLR. 

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