scholarly journals Evaluation of liver function using liver parenchyma, spleen and portal vein signal intensities during the hepatobiliary phase in Gd-EOB-DTPA-enhanced MRI

2020 ◽  
Author(s):  
Ming Yang ◽  
Yue Zhang ◽  
Wenlu Zhao ◽  
Wen Cheng ◽  
Han Wang ◽  
...  
Keyword(s):  
Liver Function ◽  
Portal Vein ◽  
Contrast Ratio ◽  
Liver Parenchyma ◽  
International Normalized Ratio ◽  
Imaging Biomarkers ◽  
Hepatobiliary Phase ◽  
Enhanced Mri ◽  
Pugh Class ◽  
Class C

Abstract Background: Previous studies have used signal intensity (SI) to reflect liver function. However, few studies have evaluated liver function via the portal vein. Regarding the SI of the liver, spleen, and portal vein, no study has indicated which can best reflect liver function. Therefore, the aim of this study is to investigate whether these parameters can evaluate liver function in patients with cirrhosis and determine which is the best parameter.Methods: 120 patients with normal livers (n = 41) or Child–Pugh class A (n = 50), B (n = 21) or C (n = 8) disease who had undergone Gd-EOB-DTPA-enhanced MRI were retrospectively reviewed. Comparisons of the MRI data (liver parenchyma SI, portal vein SI, and spleen SI and liver-to-portal vein contrast ratio (LPC), liver-to-spleen contrast ratio (LSC), and portal vein-to-spleen contrast ratio (PSC)) in the 15-min hepatobiliary phase images were performed among the groups, and the correlations among the liver function parameters (total bilirubin, direct bilirubin, indirect bilirubin, aspartate aminotransferase, alanine aminotransferase, albumin, creatinine, platelet count, prothrombin time and international normalized ratio), liver function scores and MRI data were also quantitatively analysed.Results: Significant differences were observed in the liver parenchyma SI, LPC and LSC among the groups. These values all decreased gradually from normal livers to Child–Pugh class C cirrhotic livers (P < 0.001). The portal vein SI constantly and slightly increased from normal livers to Child–Pugh class C cirrhotic livers, but no differences were found among the groups in the portal vein SI and PSC (P > 0.05). LPC showed a stronger correlation with the Child–Pugh score and MELD score than LSC and the liver parenchyma SI. The order of the AUCs of these parameters, from largest to smallest, was as follows: LPC, LSC, and liver parenchyma SI (P > 0.05).Conclusion: The liver parenchyma SI, LSC and LPC may be used as alternative imaging biomarkers to assess liver function, while the portal vein SI and PSC do not reflect liver function. Furthermore, LPC values can more effectively distinguish severity among patients with cirrhosis than the liver parenchyma SI and LSC.

scholarly journals Evaluation of liver function using liver parenchyma, spleen and portal vein signal intensities during the hepatobiliary phase in Gd-EOB-D TPA-enhanced MRI

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Ming Yang ◽  
Yue Zhang ◽  
Wenlu Zhao ◽  
Wen Cheng ◽  
Han Wang ◽  
...  
Keyword(s):  
Liver Function ◽  
Portal Vein ◽  
Contrast Ratio ◽  
Liver Parenchyma ◽  
International Normalized Ratio ◽  
Imaging Biomarkers ◽  
Hepatobiliary Phase ◽  
Enhanced Mri ◽  
Pugh Class ◽  
Class C

Abstract Background Previous studies have used signal intensity (SI) to reflect liver function. However, few studies have evaluated liver function via the portal vein. Regarding the SI of the liver, spleen, and portal vein, no study has indicated which can best reflect liver function. Therefore, the aim of this study is to investigate whether these parameters can evaluate liver function in patients with cirrhosis and determine which is the best parameter. Methods 120 patients with normal livers (n = 41) or Child–Pugh class A (n = 50), B (n = 21) or C (n = 8) disease who had undergone Gd-EOB-DTPA-enhanced MRI were retrospectively reviewed. Comparisons of the MRI data (liver parenchyma SI, portal vein SI, and spleen SI and liver-to-portal vein contrast ratio (LPC), liver-to-spleen contrast ratio (LSC), and portal vein-to-spleen contrast ratio (PSC)) in the 15-min hepatobiliary phase images were performed among the groups, and the correlations among the liver function parameters (total bilirubin, direct bilirubin, indirect bilirubin, aspartate aminotransferase, alanine aminotransferase, albumin, creatinine, platelet count, prothrombin time and international normalized ratio), liver function scores and MRI data were also quantitatively analysed. Results Significant differences were observed in the liver parenchyma SI, LPC and LSC among the groups. These values all decreased gradually from normal livers to Child–Pugh class C cirrhotic livers (P < 0.001). The portal vein SI constantly and slightly increased from normal livers to Child–Pugh class C cirrhotic livers, but no differences were found among the groups in the portal vein SI and PSC (P > 0.05). LPC showed a stronger correlation with the Child–Pugh score and MELD score than LSC and the liver parenchyma SI. The order of the AUCs of these parameters, from largest to smallest, was as follows: LPC, LSC, and liver parenchyma SI (P > 0.05). Conclusion The liver parenchyma SI, LSC and LPC may be used as alternative imaging biomarkers to assess liver function, while the portal vein SI and PSC do not reflect liver function. Furthermore, LPC values can more effectively distinguish severity among patients with cirrhosis than the liver parenchyma SI and LSC.

scholarly journals Evaluation of the liver function by the liver parenchyma, spleen and portal vein signal intensity during the hepatobiliary phase in Gd-EOB-DTPA-enhanced MRI

2020 ◽  
Author(s):  
Ming Yang ◽  
Yue Zhang ◽  
Wenlu Zhao ◽  
Wen Cheng ◽  
Han Wang ◽  
...  
Keyword(s):  
Liver Function ◽  
Portal Vein ◽  
Signal Intensity ◽  
Liver Parenchyma ◽  
International Normalized Ratio ◽  
Imaging Biomarkers ◽  
Hepatobiliary Phase ◽  
Enhanced Mri ◽  
Pugh Class ◽  
Class C

Abstract Background: Previous studies used the signal intensity (SI) to reflect liver function. However, there are still few studies on the assessment of liver function via the portal vein, and no study has pointed out that in terms of SI (liver, spleen, portal vein), which one can better reflect liver function. Therefore, the aim of this study is to investigate whether these parameters can be used to evaluate liver function in patients with cirrhosis and determine which parameter is best.Methods: A total of 120 patients with normal livers (n = 41) or Child–Pugh class A (n = 50), B (n = 21) or C (n = 8) disease who underwent Gd-EOB-DTPA-enhanced MRI were retrospectively reviewed. Comparisons of the SI of the liver parenchyma, portal vein, and spleen and liver-to-portal vein (LPC), liver-to-spleen (LSC), and portal vein-to-spleen (PSC) contrast ratios on the 15-min hepatobiliary phase images were performed among groups, and the correlations among liver function parameters (total bilirubin, direct bilirubin, indirect bilirubin, aspartate aminotransferase, alanine aminotransferase, albumin, creatinine, platelet count, prothrombin time and international normalized ratio), liver function scores and MRI date were also quantitatively analyzed.Results: Significant differences were observed in the SI of the liver parenchyma, LPC and LSC among groups. These values all decreased gradually from normal livers to Child–Pugh class C cirrhotic livers (P < 0.001). The SI of the portal vein constantly and slightly increased from normal livers to Child–Pugh class C cirrhotic livers, but there were no differences among groups in portal vein signal and PSC (P > 0.05). LPC had a stronger correlation with Child-Pugh score and MELD score than LSC and liver parenchyma SI. The order of the AUCs of these parameters, from largest to smallest, was as follows: LPC, LSC, and liver parenchyma SI (P > 0.05).Conclusion: Liver parenchyma SI, LSC and LPC may be used as alternative imaging biomarkers for assessing liver function, while the portal vein signal and PSC could not reflect liver function. Furthermore, LPC values can more effectively distinguish severity among patients with cirrhosis than liver parenchyma SI and LSC.

scholarly journals Evaluation of the liver function by the liver parenchyma, spleen and portal vein signal intensity during the hepatobiliary phase with Gd-EOB-DTPA-enhanced MRI

2020 ◽  
Author(s):  
Ming Yang ◽  
Yue Zhang ◽  
Wenlu Zhao ◽  
Wen Cheng ◽  
Han Wang ◽  
...  
Keyword(s):  
Liver Function ◽  
Mr Imaging ◽  
Portal Vein ◽  
Signal Intensity ◽  
Contrast Ratio ◽  
Liver Parenchyma ◽  
Hepatobiliary Phase ◽  
Unified Study ◽  
Pugh Class ◽  
Class C

Abstract Background: Assessment of liver function is essential for the treatment and prognosis of patients with cirrhosis, previous studies used signal intensity of hepatobiliary phase to reflect liver function on gadolinium-ethoxybenzyl-diethylenetriamine penta-acetic acid (Gd-EOB-DTPA)-enhanced MR imaging. But none of these studies has conducted a unified study on liver, spleen and portal vein. Thus, the aim of this study is to conduct a unified study, investigate whether they can be used to evaluate the liver function in patients with cirrhosis and find out which one is better.Methods: A total of 120 patients with normal (n = 41), Child–Pugh class A (n = 50), B (n = 21) or C (n = 8) who underwent Gd-EOB-DTPA-enhanced 3 Tesla MR imaging were retrospectively reviewed. Comparison of MRI date (signal intensity of liver parenchyma, portal vein, spleen, and liver-to-portal vein [LPC], liver-to-spleen [LSC], portal vein-to-spleen [PSC] contrast ratio) on hepatobiliary phase 15 min among groups, and liver function parameters was quantitatively analyzed as well.Results: A significantly difference was observed between the SI of liver parenchyma, LPC and LSC among groups (P < 0.001). They all decreased gradually from normal to cirrhotic livers with Child–Pugh class C (P < 0.001). The SI of portal vein constantly and slightly increased from normal to Child–Pugh class C, but there were not differences among the groups (P > 0.05). LPC is more correlated with Child-Pugh score or MELD score than LSC and liver parenchyma SI. A receiver operating characteristic curve analysis revealed that the AUC in order from the large to the small are: LPC, LSC, and the liver parenchyma SI (0.892, 0.889, 0.836), but the differences of AUCs among them were not significant.Conclusion: Liver parenchyma SI, LSC and LPC might be used as alternatives imaging biomarker for assessing liver function. Furthermore, LPC values can more efficaciously indicate the severity between patients with cirrhosis than SI of liver parenchyma and LSC. Although the portal vein signal shows a certain upward trend, it could not be used to reflect liver function.

Liver function correlates with liver-to-portal vein contrast ratio during the hepatobiliary phase with Gd-EOB-DTPA-enhanced MR at 3 Tesla

2018 ◽  
Vol 43 (9) ◽  
pp. 2262-2269 ◽  
Author(s):  
Weiguo Zhang ◽  
Xiao Wang ◽  
Youhan Miao ◽  
Chunhong Hu ◽  
Weifeng Zhao
Keyword(s):  
Liver Function ◽  
Portal Vein ◽  
Contrast Ratio ◽  
3 Tesla ◽  
Hepatobiliary Phase

scholarly journals Patterns of enhancement in the hepatobiliary phase of gadoxetic acid-enhanced MRI

2020 ◽  
Vol 93 (1112) ◽  
pp. 20190989
Author(s):  
Cathryn L Hui ◽  
Marcela Mautone
Keyword(s):  
Liver Parenchyma ◽  
Gadoxetic Acid ◽  
Hepatobiliary Phase ◽  
Liver Lesions ◽  
Enhanced Mri

A variety of patterns of enhancement of liver lesions and liver parenchyma is observed in the hepatobiliary phase (HBP) of gadoxetic acid-enhanced MRI. It is becoming increasingly apparent that many lesions may exhibit HBP enhancement. Much of the literature regarding the role of gadoxetic acid-enhanced MRI in characterising liver lesions is dichotomous, focusing on whether lesions are enhancing or non-enhancing in the HBP, rather than examining the patterns of enhancement. We provide a pattern-based description of HBP enhancement of liver parenchyma and of liver lesions. The role of OATP1B3 transporters, hepatocyte function and lesion composition in influencing patterns of HBP hyperintensity are discussed.

Assessing liver function: diagnostic efficacy of parenchymal enhancement and liver volume ratio of Gd-EOB-DTPA-enhanced MRI study during interstitial and hepatobiliary phase

2018 ◽  
Vol 44 (4) ◽  
pp. 1340-1349 ◽  
Author(s):  
Davide Ippolito ◽  
Anna Pecorelli ◽  
Simone Famularo ◽  
Davide Bernasconi ◽  
Eleonora Benedetta Orsini ◽  
...  
Keyword(s):  
Liver Function ◽  
Liver Volume ◽  
Volume Ratio ◽  
Hepatobiliary Phase ◽  
Diagnostic Efficacy ◽  
Enhanced Mri ◽  
Mri Study ◽  
Parenchymal Enhancement

scholarly journals Correlation of liver enhancement in gadoxetic acid–enhanced MRI with liver functions: a multicenter-multivendor analysis of hepatocellular carcinoma patients from SORAMIC trial

2021 ◽  
Author(s):  
Osman Öcal ◽  
Bora Peynircioglu ◽  
Christian Loewe ◽  
Otto van Delden ◽  
Vincent Vandecaveye ◽  
...  
Keyword(s):  
Liver Function ◽  
Total Bilirubin ◽  
Clinical Findings ◽  
Gadoxetic Acid ◽  
Imaging Biomarker ◽  
Hepatobiliary Phase ◽  
Platelet Counts ◽  
Enhanced Mri ◽  
Grading Systems ◽  
Liver Functions

Abstract Objectives To evaluate the correlation between liver enhancement on hepatobiliary phase and liver function parameters in a multicenter, multivendor study. Methods A total of 359 patients who underwent gadoxetic acid–enhanced MRI using a standardized protocol with various scanners within a prospective multicenter phase II trial (SORAMIC) were evaluated. The correlation between liver enhancement on hepatobiliary phase normalized to the spleen (liver-to-spleen ratio, LSR) and biochemical laboratory parameters, clinical findings related to liver functions, liver function grading systems (Child-Pugh and Albumin-Bilirubin [ALBI]), and scanner characteristics were analyzed using uni- and multivariate analyses. Results There was a significant positive correlation between LSR and albumin (rho = 0.193; p < 0.001), platelet counts (rho = 0.148; p = 0.004), and sodium (rho = 0.161; p = 0.002); and a negative correlation between LSR and total bilirubin (rho = −0.215; p < 0.001) and AST (rho = −0.191; p < 0.001). Multivariate analysis confirmed independent significance for each of albumin (p = 0.022), total bilirubin (p = 0.045), AST (p = 0.031), platelet counts (p = 0.012), and sodium (p = 0.006). The presence of ascites (1.47 vs. 1.69, p < 0.001) and varices (1.55 vs. 1.69, p = 0.006) was related to significantly lower LSR. Similarly, patients with ALBI grade 1 had significantly higher LSR than patients with grade 2 (1.74 ± 0.447 vs. 1.56 ± 0.408, p < 0.001); and Child-Pugh A patients had a significantly higher LSR than Child-Pugh B (1.67 ± 0.44 vs. 1.49 ± 0.33, p = 0.021). Also, LSR was negatively correlated with MELD-Na scores (rho = −0.137; p = 0.013). However, one scanner brand was significantly associated with lower LSR (p < 0.001). Conclusions The liver enhancement on the hepatobiliary phase of gadoxetic acid–enhanced MRI is correlated with biomarkers of liver functions in a multicenter cohort. However, this correlation shows variations between scanner brands. Key Points • The correlation between liver enhancement on the hepatobiliary phase of gadoxetic acid–enhanced MRI and liver function is consistent in a multicenter-multivendor cohort. • Signal intensity–based indices (liver-to-spleen ratio) can be used as an imaging biomarker of liver function. • However, absolute values might change between vendors.

Assessing liver function by liver enhancement during the hepatobiliary phase with Gd-EOB-DTPA-enhanced MRI at 3 Tesla

2014 ◽  
Vol 24 (5) ◽  
pp. 1013-1019 ◽  
Author(s):  
N. Verloh ◽  
M. Haimerl ◽  
F. Zeman ◽  
M. Schlabeck ◽  
A. Barreiros ◽  
...  
Keyword(s):  
Liver Function ◽  
3 Tesla ◽  
Hepatobiliary Phase ◽  
Enhanced Mri

Histogram analysis of noncancerous liver parenchyma on gadoxetic acid-enhanced MRI: predictive value for liver function and pathology

2016 ◽  
Vol 41 (9) ◽  
pp. 1751-1757 ◽  
Author(s):  
Yoshiki Asayama ◽  
Akihiro Nishie ◽  
Kousei Ishigami ◽  
Yasuhiro Ushijima ◽  
Yukihisa Takayama ◽  
...  
Keyword(s):  
Liver Function ◽  
Predictive Value ◽  
Liver Parenchyma ◽  
Gadoxetic Acid ◽  
Histogram Analysis ◽  
Enhanced Mri

scholarly journals Brief communication (Original). Correlation between liver signal intensity in hepatobiliary phase of Gd-EOB-DTPA enhancement and liver function reserves

2014 ◽  
Vol 8 (3) ◽  
pp. 411-415
Author(s):  
Natthaporn Tanpowpong ◽  
Teerasak Phewplung
Keyword(s):  
Liver Function ◽  
Signal Intensity ◽  
Signal To Noise Ratio ◽  
Interobserver Reliability ◽  
Statistical Significance ◽  
Three Dimensional ◽  
Negative Relationship ◽  
Liver Parenchyma ◽  
Meld Score ◽  
Hepatobiliary Phase

Abstract Background: Gadolinium diethylenetriamine-pentaacetic acid (Gd-EOB-DTPA) is a developed agent with preferential uptake by hepatocytes. A rapid and specific hepatocyte uptake with biliary excretion was observed of approximately 50% of the injected dose. The amount of contrast uptake is thought to be related to reserve liver function. Objectives: To evaluate correlation between liver signal intensity in the hepatobiliary phase of Gd-EOB-DTPA and reserved liver function by using the model score for end-stage liver disease (MELD). Methods:All patients who underwent magnetic resonance (MR) imaging with Gd-EOB-DTPA were retrospectively collected. The patients with serum creatinine level higher than 1.5 mg/dL or patients without available data to estimate MELD score were excluded. Thirty-six patients were enrolled. A signal-to-noise ratio (SNR) in the liver parenchyma on a fat-suppressed three dimensional fast spoiled-gradient recalled echo sequence images before and 20 minutes after contrast injection were measured and calculated on PACS by two radiologists. The MELD score was determined and interobserver reliability was estimated. Results: Among 36 patients, we found a negative relationship between the percentage enhancement and the MELD score (P < 0.01, r = 0.545). The SNR at 20 minutes after Gd-EOB-DTPA injection also had a negative relationship with the MELD score with statistical significance (P < 0.01, r = 0.460). Interobserver reliability was 0.675. Conclusion: The percentage enhancement in hepatobiliary phase of Gd-EOB-DTPA can predict reserved liver function.

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