Polyneuropathy with endoneurial immune complex deposition as the first manifestation of systemic lupus erythematosus

1998 ◽  
Vol 96 (3) ◽  
pp. 297-300 ◽  
Author(s):  
I. Bódi ◽  
P. Váradi ◽  
G. Pokorny ◽  
J. Engelhardt ◽  
G. Dibó ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Immune Complex ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Immune Complex Deposition ◽  
Complex Deposition

Extraglomerular immune complex deposition in lupus nephritis

Lupus ◽  
2021 ◽  
pp. 096120332110625
Author(s):  
Valentina Papa ◽  
James Brainer ◽  
Kammi J Henriksen ◽  
Giovanna Cenacchi ◽  
Anthony Chang
Keyword(s):  
Electron Microscopy ◽  
Systemic Lupus Erythematosus ◽  
Retrospective Study ◽  
Lupus Nephritis ◽  
Immune Complex ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Immune Complex Deposition ◽  
Complex Deposition ◽  
Common Manifestation

Background Lupus nephritis (LN) is a common manifestation and a major cause of morbidity and mortality in systemic lupus erythematosus (SLE) patients. It is characterized by glomerular and often extraglomerular immune complex deposition. Purpose Given the emerging importance of the tubulointerstitial compartment, we conducted a retrospective study of 78 LN biopsies to enumerate the spectrum of extraglomerular immune complex deposition that can be observed in lupus nephritis by electron microscopy and to identify possible clinical or pathologic correlates. Results The presence of tubulointerstitial immune complex deposition often accompanied interstitial inflammation, but some discrepancies were also seen. Conclusions As target antigens are identified, correlation with glomerular, tubulointerstitial, and vascular immune complex deposition will be of increasing interest.

Alveolar Hemorrhage and Renal Microangiopathy in Systemic Lupus Erythematosus

2001 ◽  
Vol 125 (4) ◽  
pp. 475-483 ◽  
Author(s):  
Michael D. Hughson ◽  
Zhi He ◽  
Jeffrey Henegar ◽  
Robert McMurray
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Immune Complex ◽  
Lupus Erythematosus ◽  
Alveolar Hemorrhage ◽  
Alveolar Wall ◽  
Systemic Lupus ◽  
Immune Complex Deposition ◽  
Complex Deposition ◽  
Lung And Kidney ◽  
Renal Lupus

Abstract Context.—Acute alveolar hemorrhage in systemic lupus erythematosus usually occurs as a pulmonary-renal syndrome. In most cases, the lungs show “bland” alveolar hemorrhage with little or no inflammation. Whether this alveolar injury is similar to the better-defined noninflammatory renal lupus vasculopathy is unresolved. Objectives.—To investigate the relationships and the mechanisms of small vascular injury in the lung and kidney of 2 lupus patients who died of diffuse AH. Methods.—We investigated the relationship of AH to immune complex deposition in the lungs of 6 patients with systemic lupus erythematosus and correlated the findings with glomerular and vascular disease in the kidney. Lung and kidney were studied by light, immunofluorescence, and/or electron microscopy; apoptosis was investigated using in situ nick-end labeling. Results.—The clinical course of 2 patients was complicated by alveolar hemorrhage, and the lungs of these patients revealed alveolar wall immune complex deposits and bland alveolar hemorrhage. These 2 patients had World Health Organization class IV lupus nephritis and renal arterioles involved by a noninflammatory lupus vasculopathy. Apoptosis was identified in the lupus microangiopathy and in alveolar walls within areas of alveolar hemorrhage. Alveolar wall immune complex deposits were not found in 4 patients who had a lupus glomerulonephritis but did not have renal lupus vasculopathy. Apoptosis was not seen in renal arterioles or lungs of these 4 cases, except in areas of diffuse alveolar damage or herpesvirus pneumonia. Conclusions.—Our findings indicate that alveolar hemorrhage in systemic lupus erythematosus, characterized by bland alveolar wall changes, is pathogenetically similar to the lupus microangiopathy of the kidney. In both lung and kidney, the pathogenesis of the microvascular injury appears to be related to immune complex deposition and the induction of apoptosis.

scholarly journals Acute Effects of Steroids On Immune Complex Profile of Patients with Systemic Lupus Erythematosus

1983 ◽  
Vol 26 (5) ◽  
pp. 637-644 ◽  
Author(s):  
Robert E. Boyd ◽  
Daniel A. Birchmore ◽  
Donald L. Kaiser ◽  
Alice C. Young ◽  
John S. Davis
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Immune Complex ◽  
Lupus Erythematosus ◽  
Acute Effects ◽  
Complex Profile ◽  
Systemic Lupus
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