Efficacy and safety of edaravone in treatment of amyotrophic lateral sclerosis—a systematic review and meta-analysis

2018 ◽  
Vol 40 (2) ◽  
pp. 235-241 ◽  
Author(s):  
Linting Luo ◽  
Zhibin Song ◽  
Xiaoqiang Li ◽  
Huiwang ◽  
Yaqing Zeng ◽  
...  
Keyword(s):  
Systematic Review ◽  
Amyotrophic Lateral Sclerosis ◽  
Meta Analysis ◽  
Efficacy And Safety ◽  
Lateral Sclerosis

Systematic review and meta-analysis of efficacy and safety of stem cell therapy in Amyotrophic lateral sclerosis

Cytotherapy ◽  
2015 ◽  
Vol 17 (6) ◽  
pp. S66 ◽  
Author(s):  
Hyunsuk Jeong ◽  
Hyeon Woo Yim ◽  
Young-seung Cho ◽  
Hyun-bin kim ◽  
Il-Hoan Oh ◽  
...  
Keyword(s):  
Systematic Review ◽  
Amyotrophic Lateral Sclerosis ◽  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Meta Analysis ◽  
Efficacy And Safety ◽  
Lateral Sclerosis

Statins and risk of amyotrophic lateral sclerosis: a systematic review and meta-analysis

2021 ◽  
Author(s):  
Fardin Nabizadeh ◽  
Mohammad Balabandian ◽  
Amir Mohammad Sharafi ◽  
Ali Ghaderi ◽  
Mohammad Reza Rostami ◽  
...  
Keyword(s):  
Systematic Review ◽  
Amyotrophic Lateral Sclerosis ◽  
Meta Analysis ◽  
Lateral Sclerosis

Genetic epidemiology of amyotrophic lateral sclerosis: a systematic review and meta-analysis

2017 ◽  
Vol 88 (7) ◽  
pp. 540-549 ◽  
Author(s):  
Zhang-Yu Zou ◽  
Zhi-Rui Zhou ◽  
Chun-Hui Che ◽  
Chang-Yun Liu ◽  
Rao-Li He ◽  
...  
Keyword(s):  
Systematic Review ◽  
Amyotrophic Lateral Sclerosis ◽  
Genetic Epidemiology ◽  
Meta Analysis ◽  
Lateral Sclerosis

scholarly journals Protocol for a systematic review and meta-analysis of experimental models of amyotrophic lateral sclerosis

2016 ◽  
Vol 3 (2) ◽  
pp. e00023
Author(s):  
J. M. Gregory ◽  
F. M. Waldron ◽  
T. Soane ◽  
L. Fulton ◽  
D. Leighton ◽  
...  
Keyword(s):  
Systematic Review ◽  
Amyotrophic Lateral Sclerosis ◽  
Meta Analysis ◽  
Experimental Models ◽  
Lateral Sclerosis

Global variation in prevalence and incidence of amyotrophic lateral sclerosis: a systematic review and meta-analysis

2019 ◽  
Vol 267 (4) ◽  
pp. 944-953 ◽  
Author(s):  
Lu Xu ◽  
Tanxin Liu ◽  
Lili Liu ◽  
Xiaoying Yao ◽  
Lu Chen ◽  
...  
Keyword(s):  
Systematic Review ◽  
Amyotrophic Lateral Sclerosis ◽  
Meta Analysis ◽  
Global Variation ◽  
Lateral Sclerosis

scholarly journals Prognostic value of phrenic nerve conduction study in amyotrophic lateral sclerosis: Systematic review and meta-analysis

2020 ◽  
Vol 131 (1) ◽  
pp. 106-113 ◽  
Author(s):  
Cláudia S. Silva ◽  
Filipe B. Rodrigues ◽  
Gonçalo S. Duarte ◽  
João Costa ◽  
Mamede de Carvalho
Keyword(s):  
Systematic Review ◽  
Amyotrophic Lateral Sclerosis ◽  
Nerve Conduction Study ◽  
Phrenic Nerve ◽  
Nerve Conduction ◽  
Prognostic Value ◽  
Meta Analysis ◽  
Lateral Sclerosis

Efficacy and safety of mexiletine in amyotrophic lateral sclerosis: a systematic review of randomized controlled trials

2020 ◽  
Vol 10 (6) ◽  
pp. 397-407
Author(s):  
Karen Joy B Adiao ◽  
Adrian I Espiritu ◽  
Marjorie Anne C Bagnas
Keyword(s):  
Systematic Review ◽  
Amyotrophic Lateral Sclerosis ◽  
Randomized Controlled Trials ◽  
Functional Disability ◽  
Common Adverse Effect ◽  
Muscle Cramp ◽  
Controlled Trials ◽  
Efficacy And Safety ◽  
Randomized Controlled ◽  
Lateral Sclerosis

Background: Mexiletine is a potential drug in amyotrophic lateral sclerosis (ALS) that has been tested in clinical trials. The objective of this study was to determine the efficacy and safety of mexiletine in ALS via systematic review of existing evidences. Materials & methods: Relevant records were searched using major healthcare electronic databases. Data on functional disability, impairment, survival, muscle cramp frequency and severity, and adverse events were obtained. Results & conclusion: Three relevant randomized controlled trials with 141 patients were included in this review. Mexiletine has no effect on the functional disability, impairment and survival in ALS. However, significant improvement in reducing muscle cramp severity and frequency was shown. The most common adverse effect associated with mexiletine intake among ALS patients are nausea (n = 11, 7.8%) and tremors (n = 5, 3.6%).

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