Small vessel disease and clinical outcomes after endovascular treatment in acute ischemic stroke

2019 ◽  
Vol 40 (6) ◽  
pp. 1227-1235 ◽  
Author(s):  
Francesco Arba ◽  
Giuseppe Dario Testa ◽  
Nicola Limbucci ◽  
Sergio Nappini ◽  
Leonardo Renieri ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Endovascular Treatment ◽  
Acute Ischemic Stroke ◽  
Clinical Outcomes ◽  
Small Vessel Disease ◽  
Small Vessel ◽  
Vessel Disease

scholarly journals Imaging Markers of Brain Frailty and Outcome in Patients With Acute Ischemic Stroke

Stroke ◽  
2021 ◽  
Author(s):  
Ning Bu ◽  
Mohamed Salah Khlif ◽  
Robin Lemmens ◽  
Anke Wouters ◽  
Jochen B. Fiebach ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Functional Outcome ◽  
Small Vessel Disease ◽  
Small Vessel ◽  
Excellent Outcome ◽  
Vessel Disease ◽  
Brain Parenchymal Fraction ◽  
Imaging Markers ◽  
Brain Parenchymal

Background and Purpose: Functional outcome after stroke may be related to preexisting brain health. Several imaging markers of brain frailty have been described including brain atrophy and markers of small vessel disease. We investigated the association of these imaging markers with functional outcome after acute ischemic stroke. Methods: We retrospectively studied patients with acute ischemic stroke enrolled in the AXIS-2 trial (AX200 in Ischemic Stroke Trial), a randomized controlled clinical trial of granulocyte colony-stimulating factor versus placebo. We assessed the ratio of brain parenchymal volume to total intracerebral volumes (ie, the brain parenchymal fraction) and total brain volumes from routine baseline magnetic resonance imaging data obtained within 9 hours of symptom onset using the unified segmentation algorithm in SPM12. Enlarged perivascular spaces, white matter hyperintensities, lacunes, as well as a small vessel disease burden, were rated visually. Functional outcomes (modified Rankin Scale score) at day 90 were determined. Logistic regression was used to test associations between brain imaging features and functional outcomes. Results: We enrolled 259 patients with a mean age of 69±12 years and 46 % were female. Increased brain parenchymal fraction was associated with higher odds of excellent outcome (odds ratio per percent increase, 1.078 [95% CI, 1.008–1.153]). Total brain volumes and small vessel disease burden were not associated with functional outcome. An interaction between brain parenchymal fraction and large vessel occlusion on excellent outcome was not observed. Conclusions: Global brain health, as assessed by brain parenchymal fraction on magnetic resonance imaging, is associated with excellent functional outcome after ischemic stroke. REGISTRATION: URL: https://www.clinicaltrials.gov . Unique identifier: NCT00927836.

scholarly journals Total Small Vessel Disease Burden Predicts Functional Outcome in Patients With Acute Ischemic Stroke

2019 ◽  
Vol 10 ◽  
Author(s):  
Ying-chao Huo ◽  
Qi Li ◽  
Wen-yu Zhang ◽  
Ning Zou ◽  
Rui Li ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Functional Outcome ◽  
Disease Burden ◽  
Small Vessel Disease ◽  
Small Vessel ◽  
Vessel Disease

scholarly journals Total Cerebral Small-Vessel Disease Score is Associated with Mortality during Follow-Up after Acute Ischemic Stroke

2017 ◽  
Vol 13 (2) ◽  
pp. 187 ◽  
Author(s):  
Tae-Jin Song ◽  
Jinkwon Kim ◽  
Dongbeom Song ◽  
Joonsang Yoo ◽  
Hye Sun Lee ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Disease Score ◽  
Vessel Disease

Clinical and biochemical diagnosis of small-vessel disease in acute ischemic stroke

2009 ◽  
Vol 285 (1-2) ◽  
pp. 185-190 ◽  
Author(s):  
Raf Brouns ◽  
Jan Van Den Bossche ◽  
Didier De Surgeloose ◽  
Rishi Sheorajpanday ◽  
Peter P. De Deyn
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Small Vessel Disease ◽  
Small Vessel ◽  
Vessel Disease ◽  
Biochemical Diagnosis
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