Synthesis and Biological Evaluation of Novel Methyl 2-Hydroxy-5-Substituted Benzoate Derivatives as Mushroom Tyrosinase Inhibitors

2014 ◽  
Vol 50 (4) ◽  
pp. 598-602
Author(s):  
Yu Jun Wang ◽  
Li Dan Xiong ◽  
Chang Wei Song ◽  
Li Li ◽  
Ying Li ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Mushroom Tyrosinase ◽  
Tyrosinase Inhibitors ◽  
Synthesis And Biological Evaluation ◽  
Benzoate Derivatives

Synthesis and biological evaluation of helicid analogues as mushroom tyrosinase inhibitors

2008 ◽  
Vol 18 (24) ◽  
pp. 6490-6493 ◽  
Author(s):  
Wei Yi ◽  
Rihui Cao ◽  
Huan Wen ◽  
Qin Yan ◽  
Binhua Zhou ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Mushroom Tyrosinase ◽  
Tyrosinase Inhibitors ◽  
Synthesis And Biological Evaluation

Synthesis and biological evaluation of a novel series of bis-salicylaldehydes as mushroom tyrosinase inhibitors

2010 ◽  
Vol 20 (20) ◽  
pp. 6138-6140 ◽  
Author(s):  
Giovanna Delogu ◽  
Gianni Podda ◽  
Marcella Corda ◽  
Maria Benedetta Fadda ◽  
Antonella Fais ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Mushroom Tyrosinase ◽  
Tyrosinase Inhibitors ◽  
Synthesis And Biological Evaluation

Design, synthesis and biological evaluation of (1,3-diphenyl-1H-pyrazol-4-yl) methyl benzoate derivatives as potential BRAFV600E inhibitors

RSC Advances ◽  
2014 ◽  
Vol 4 (95) ◽  
pp. 52702-52711 ◽  
Author(s):  
Ya-Juan Qin ◽  
Man Xing ◽  
Ya-Liang Zhang ◽  
Jigar A. Makawana ◽  
Ai-Qin Jiang ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Biological Evaluation ◽  
Methyl Benzoate ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation ◽  
Potent Inhibitory Activity ◽  
Benzoate Derivatives

A series of (1,3-diphenyl-1H-pyrazol-4-yl) methyl benzoate derivatives (6a–10d) were designed and synthesized and evaluated as BRAFV600 inhibitors. Among them, compound 10a showed the most potent inhibitory activity against A375, WM266.4 and BRAFV600Ein vitro with IC50 values of 1.36 μM, 0.94 μM and 0.11 μM, respectively.

scholarly journals Synthesis and Biological Evaluation of Kojic acid Derivatives as Tyrosinase Inhibitors

2014 ◽  
Vol 35 (12) ◽  
pp. 3647-3650 ◽  
Author(s):  
Yeong Jin Choi ◽  
Ho Sik Rho ◽  
Heung Soo Baek ◽  
Yong Deog Hong ◽  
Yung Hyup Joo ◽  
...  
Keyword(s):  
Kojic Acid ◽  
Biological Evaluation ◽  
Tyrosinase Inhibitors ◽  
Synthesis And Biological Evaluation
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