Milan Criteria, Multi-nodularity, and Microvascular Invasion Predict the Recurrence Patterns of Hepatocellular Carcinoma After Resection

2012 ◽  
Vol 17 (4) ◽  
pp. 702-711 ◽  
Author(s):  
Hung-Hsu Hung ◽  
Hao-Jan Lei ◽  
Gar-Yang Chau ◽  
Chien-Wei Su ◽  
Cheng-Yuan Hsia ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Microvascular Invasion ◽  
Milan Criteria ◽  
Recurrence Patterns

scholarly journals Microvascular Invasion in HCC: The Molecular Imaging Perspective

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Vincenzo Cuccurullo ◽  
Giuseppe Danilo Di Stasio ◽  
Giuseppe Mazzarella ◽  
Giuseppe Lucio Cascini
Keyword(s):  
Hepatocellular Carcinoma ◽  
Positron Emission Tomography ◽  
Liver Transplantation ◽  
Microvascular Invasion ◽  
Emission Tomography ◽  
Milan Criteria ◽  
Imaging Biomarker ◽  
Preoperative Imaging ◽  
Primary Liver Tumor ◽  
Positron Emission

Hepatocellular carcinoma represents the most frequent primary liver tumor; curative options are only surgical resection and liver transplantation. From 1996, Milan Criteria are applied in consideration of patients with cirrhosis and hepatocellular for liver transplantation; nonetheless, more recently, Milan Criteria have been criticized because they appear over conservative. Apart from number and size of lesions and biomarker levels, which already have been associated with poorer prognosis, overall survival and recurrence rates after transplantation are affected also by the presence of vascular invasion. Microvascular invasion suggests a poor prognosis but it is often hard to detect before transplant. Diagnostic imaging and tumor markers may play an important role and become the main tools to define microvascular invasion. In particular, a possible role could be found for computed tomography, magnetic resonance imaging, and positron emission tomography. In this paper, we analyze the possible role of positron emission tomography as a preoperative imaging biomarker capable of predicting microvascular invasion in patients with hepatocellular carcinoma and thus selecting optimal candidates for liver transplantation.

Recurrence Patterns After Hepatectomy of Hepatocellular Carcinoma: Implication of Milan Criteria Utilization

2009 ◽  
Vol 16 (6) ◽  
pp. 1560-1571 ◽  
Author(s):  
Toshiya Kamiyama ◽  
Kazuaki Nakanishi ◽  
Hideki Yokoo ◽  
Hirofumi Kamachi ◽  
Munenori Tahara ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Milan Criteria ◽  
Recurrence Patterns

A Clinical Scoring System for Predicting Microvascular Invasion in Patients with Hepatocellular Carcinoma Within the Milan Criteria

2019 ◽  
Vol 23 (4) ◽  
pp. 779-787 ◽  
Author(s):  
Tomoki Ryu ◽  
Yuko Takami ◽  
Yoshiyuki Wada ◽  
Masaki Tateishi ◽  
Takanobu Hara ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Scoring System ◽  
Microvascular Invasion ◽  
Milan Criteria ◽  
Clinical Scoring

Potential predictive factors for microvascular invasion in hepatocellular carcinoma classified within the Milan criteria

2017 ◽  
Vol 23 (1) ◽  
pp. 98-103 ◽  
Author(s):  
Satoru Imura ◽  
Hiroki Teraoku ◽  
Masato Yoshikawa ◽  
Daichi Ishikawa ◽  
Shinichiro Yamada ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Predictive Factors ◽  
Microvascular Invasion ◽  
Milan Criteria

Predictors of microvascular invasion in patients with hepatocellular carcinoma who are candidates for orthotopic liver transplanation

2001 ◽  
Vol 120 (5) ◽  
pp. A90-A90
Author(s):  
N ESNAOLA ◽  
G LAUWERS ◽  
N MIRZA ◽  
D NAGORNEY ◽  
D DOHERTY ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Microvascular Invasion
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