Is There Any Clinical Benefit for Peri-operative Administration of Tranexamic Acid for Patients Undergoing Percutaneous Nephrolithotomy? A Systematic Review and Meta-analysis

2021 ◽  
Vol 22 (12) ◽  
Author(s):  
Panagiotis Kallidonis ◽  
Athanasios Vagionis ◽  
Konstantinos Pagonis ◽  
Angelis Peteinaris ◽  
Amelia Pietropaolo ◽  
...  
Keyword(s):  
Systematic Review ◽  
Tranexamic Acid ◽  
Percutaneous Nephrolithotomy ◽  
Clinical Benefit ◽  
Meta Analysis

scholarly journals Can tranexamic acid reduce the blood transfusion rate in patients undergoing percutaneous nephrolithotomy? A systematic review and meta-analysis

2020 ◽  
Vol 48 (4) ◽  
pp. 030006052091756
Author(s):  
Zhenghao Wang ◽  
Xiao He ◽  
Yunjin Bai ◽  
Jia Wang
Keyword(s):  
Systematic Review ◽  
Blood Transfusion ◽  
Tranexamic Acid ◽  
Percutaneous Nephrolithotomy ◽  
Selection Process ◽  
Meta Analysis ◽  
Length Of Hospital Stay ◽  
Cochrane Library ◽  
Transfusion Rate ◽  
Substantial Impact

Objective A systematic review and meta-analysis was conducted to explore the efficacy of tranexamic acid (TXA) in reducing transfusion events in patients undergoing percutaneous nephrolithotomy (PCNL). Methods PubMed, Web of Science, Embase, EBSCO, and Cochrane library databases from January 1980 to October 2019 were searched for randomized controlled trials (RCTs) that assessed TXA efficacy in reducing transfusion events during PCNL. Intervention treatments include using TXA compared with placebo (or no intervention) for patients who underwent PCNL. The search strategy and study selection process were managed in accordance with the PRISMA statement. Results Six RCTs are included in the meta-analysis. Overall, TXA intervention groups showed a significant reduction in blood transfusion events (RR = 0.34; 95% confidence interval [CI] = 0.19 to 0.62), hemoglobin decrease (MD = −0.80; 95% CI = −1.32 to −0.28), operative time (MD = −12.62; 95% CI = −15.62 to −9.61), and length of hospital stay (MD = −0.73; 95% CI = −1.36 to −0.10) compared with control groups after PCNL. However, TXA had no substantial impact on the rate of stone clearance (RR = 1.10; 95% CI = 1.00 to 1.21). Conclusions TXA can effectively reduce the transfusion rate and blood loss during PCNL.

Tranexamic Acid in Gastrointestinal Bleeding: A Systematic Review and Meta-Analysis

2020 ◽  
Author(s):  
Joanna C. Dionne ◽  
Simon JW Oczkowski ◽  
Beverley J. Hunt ◽  
Massimo Antonelli ◽  
Marije Wijnberge ◽  
...  
Keyword(s):  
Systematic Review ◽  
Gastrointestinal Bleeding ◽  
Tranexamic Acid ◽  
Meta Analysis

Effect of Tranexamic Acid in Subarachnoid Haemorrhage. A Systematic Review and Meta-Analysis

2020 ◽  
Author(s):  
Jean-Baptiste Bouillon-Minois ◽  
Carolyne Croizier ◽  
Julien S. Baker ◽  
Farès Moustafa ◽  
Jeannot Schmidt ◽  
...  
Keyword(s):  
Systematic Review ◽  
Subarachnoid Haemorrhage ◽  
Tranexamic Acid ◽  
Meta Analysis

scholarly journals Clinical benefit for cryopreservation of single human spermatozoa for ICSI: A systematic review and meta‐analysis

Andrology ◽  
2021 ◽  
Author(s):  
Chuan Huang ◽  
Run‐Xin Gan ◽  
Jian‐Lin Hu ◽  
Feng Liu ◽  
Yan Hong ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Benefit ◽  
Meta Analysis ◽  
Human Spermatozoa

Systematic review and meta-analysis of the use of tranexamic acid in tonsillectomy

2012 ◽  
Vol 270 (2) ◽  
pp. 735-748 ◽  
Author(s):  
Chee Ching Chan ◽  
Yee Yin Chan ◽  
Faiz Tanweer
Keyword(s):  
Systematic Review ◽  
Tranexamic Acid ◽  
Meta Analysis
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