Nasal Framework Reconstruction in Patient with Eosinophilic Angiocentric Fibrosis

Abstract We present the case of a 45-year-old man who presented with medication-resistant chronic bilateral nasal obstruction. The patient had no known history of allergy or any other disease. Nasal septoplasty was performed to relieve his symptoms. Histologically, thick collagen bundles were seen, characteristically whorling around vessels in a fibrotic stroma. Inflammatory cells, rich in eosinophils, were scattered throughout the lesion. No granulomas, necrosis, or vessel destruction were present. A diagnosis of eosinophilic angiocentric fibrosis was made. This neoplasm, which has very characteristic histologic features, is a rare entity of the sinonasal tract.

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Eosinophilic angiocentric fibrosis of orbit

Indian Journal of Pathology and Microbiology ◽

10.4103/0377-4929.72086 ◽

2010 ◽

Vol 53 (4) ◽

pp. 850 ◽

Cited By ~ 6

Author(s):

Muhammad Azam ◽

YousufA Husen ◽

SheemaH Hasan

Keyword(s):

Eosinophilic Angiocentric Fibrosis

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Image Gallery: Concomitant eosinophilic angiocentric fibrosis and granuloma faciale

British Journal of Dermatology ◽

10.1111/bjd.16574 ◽

2018 ◽

Vol 178 (6) ◽

pp. e395-e395

Author(s):

Y.-K. Xiang ◽

R.-Y. Fang ◽

S. Zhang ◽

Y. Yan ◽

B. Wang ◽

...

Keyword(s):

Granuloma Faciale ◽

Eosinophilic Angiocentric Fibrosis

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A Concomitant Case of Orbital Granuloma Faciale and Eosinophilic Angiocentric Fibrosis

Ophthalmic Plastic and Reconstructive Surgery ◽

10.1097/iop.0000000000000725 ◽

2017 ◽

Vol 33 (2) ◽

pp. e47-e49 ◽

Cited By ~ 1

Author(s):

Valerie H. Chen ◽

Hans E. Grossniklaus ◽

John M. DelGaudio ◽

Hee Joon Kim

Keyword(s):

Granuloma Faciale ◽

Eosinophilic Angiocentric Fibrosis

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Eosinophilic Angiocentric Fibrosis: A Review and Update of Its Association With Immunoglobulin G4–Related Disease

Archives of Pathology & Laboratory Medicine ◽

10.5858/arpa.2017-0223-rs ◽

2018 ◽

Vol 142 (12) ◽

pp. 1560-1563

Author(s):

Janice Ahn ◽

Melina Flanagan

Keyword(s):

Head And Neck ◽

Plasma Cells ◽

Neck Region ◽

Immunoglobulin G4 ◽

Head And Neck Region ◽

Related Disease ◽

Igg4 Related Disease ◽

Previous Trauma ◽

Eosinophilic Angiocentric Fibrosis

Eosinophilic angiocentric fibrosis is a rare indolent lesion of the head and neck region that has characteristic histologic findings of onionskin fibrosis and prominent eosinophils. Its pathogenesis has been poorly understood and has been most commonly attributed to hypersensitivity or previous trauma. Recently, the lesion has been included in the spectrum of immunoglobulin G4 (IgG4)–related disease. However, few of the existing cases of eosinophilic angiocentric fibrosis have been evaluated for IgG4+ and IgG+ plasma cells. Therefore, we provide an update on the clinical and histologic features of eosinophilic angiocentric fibrosis to increase awareness of the entity and encourage its further characterization as an IgG4-related disease.

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