scholarly journals Population Pharmacokinetics of Alemtuzumab (Campath) in Pediatric Hematopoietic Cell Transplantation: Towards Individualized Dosing to Improve Outcome

2019 ◽  
Vol 58 (12) ◽  
pp. 1609-1620 ◽  
Author(s):  
Rick Admiraal ◽  
Cornelia M. Jol-van der Zijde ◽  
Juliana M. Furtado Silva ◽  
Catherijne A. J. Knibbe ◽  
Arjan C. Lankester ◽  
...  
Keyword(s):  
Population Pharmacokinetics ◽  
Cell Transplantation ◽  
Hematopoietic Cell Transplantation ◽  
Hematopoietic Cell ◽  
Improve Outcome ◽  
Individualized Dosing

scholarly journals Case Report of a Child after Hematopoietic Cell Transplantation with Acute Aspergillus Tracheobronchitis as a Cause for Respiratory Failure

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Stefanie Gauguet ◽  
Kate Madden ◽  
Jennifer Wu ◽  
Christine Duncan ◽  
Gi Soo Lee ◽  
...  
Keyword(s):  
Respiratory Failure ◽  
Cell Transplantation ◽  
Hematopoietic Cell Transplantation ◽  
Hematopoietic Cell ◽  
Myelogenous Leukemia ◽  
Treatment Modalities ◽  
Improve Outcome ◽  
Delay In Diagnosis ◽  
Uncommon Presentation ◽  
Invasive Mycosis

Rapid respiratory failure due to invasive mycosis of the airways is an uncommon presentation of Aspergillus infection, even in immunocompromised patients, and very few pediatric cases have been reported. Patients with Aspergillus tracheobronchitis present with nonspecific symptoms, and radiologic studies are often noninformative, leading to a delay in diagnosis. Prompt initiation of adequate antifungal therapies is of utmost importance to improve outcome. We report the case of a 9-year-old girl with chronic myelogenous leukemia who developed respiratory distress 41 days after hematopoietic cell transplantation and rapidly deteriorated despite multiple interventions and treatment modalities.

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