Colistimethate Sodium Dry Powder for Inhalation: A Review of Its Use in the Treatment of Chronic Pseudomonas aeruginosa Infection in Patients with Cystic Fibrosis

Drugs ◽  
2014 ◽  
Vol 74 (3) ◽  
pp. 377-387 ◽  
Author(s):  
Daniel Conole ◽  
Gillian M. Keating
Keyword(s):  
Cystic Fibrosis ◽  
Pseudomonas Aeruginosa ◽  
Dry Powder ◽  
Colistimethate Sodium ◽  
Pseudomonas Aeruginosa Infection

scholarly journals Systematic Review of Colistimethate Sodium Dry Powder and Tobramycin Dry Powder Antibiotics for Pseudomonas Aeruginosa Lung Infection in Cystic Fibrosis

2013 ◽  
Vol 16 (7) ◽  
pp. A367
Author(s):  
S.E. Harnan ◽  
L. Uttley ◽  
A. Cantrell ◽  
C.J. Taylor ◽  
M. Walshaw ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cystic Fibrosis ◽  
Pseudomonas Aeruginosa ◽  
Lung Infection ◽  
Dry Powder ◽  
Colistimethate Sodium

scholarly journals Ease of use of tobramycin inhalation powder compared with nebulized tobramycin and colistimethate sodium: a crossover study in cystic fibrosis patients with pulmonary Pseudomonas aeruginosa infection

2017 ◽  
Vol 11 (7) ◽  
pp. 249-260 ◽  
Author(s):  
James Greenwood ◽  
Carsten Schwarz ◽  
Urte Sommerwerck ◽  
Edward F Nash ◽  
Michael Tamm ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Pseudomonas Aeruginosa ◽  
Treatment Satisfaction ◽  
Forced Expiratory Volume ◽  
Ease Of Use ◽  
Open Label ◽  
Administration Time ◽  
Colistimethate Sodium ◽  
Pseudomonas Aeruginosa Infection ◽  
Inhalation Powder

Background: This study assessed the ease of use of tobramycin inhalation powder (TIP) administered via T-326 inhaler versus tobramycin inhalation solution (TIS) and colistimethate sodium (COLI), both administered via nebulizers, for the treatment of chronic pulmonary Pseudomonas aeruginosa infection in patients with cystic fibrosis (CF). Methods: A real-world, open-label, crossover, interventional phase IV study was conducted in CF patients aged ⩾6 years with forced expiratory volume in 1 second (FEV1) ⩾25% to ⩽90% predicted. Patients were assigned to one of the three treatment arms in Cycle 1; all patients received TIP in Cycle 2. Each cycle consisted of 28 days on and 28 days off the treatment. Results: A total of 60 patients [mean (standard deviation) age, 27.6 (8.4) years] were allocated to three treatment arms [TIS/TIP ( n = 14); COLI/TIP ( n = 28); TIP/TIP ( n = 18)] in Cycle 1. The mean total administration time, which included device setup and cleaning, in Cycle 1 versus Cycle 2 for TIS/TIP, COLI/TIP, and TIP/TIP arms were 37.0 versus 5.0 min, 16.4 versus 3.8 min, and 4.2 versus 3.4 min, respectively. The difference in mean total administration time was significantly shorter in Cycle 2 than in Cycle 1 for TIS/TIP ( p = 0.0112) and COLI/TIP ( p = 0.0016) arms. Overall, 12 patients were found to have contaminated devices across the two treatment cycles. In the TIP/TIP arm, no contamination of the T-326 inhaler was observed in either cycle. Treatment satisfaction, assessed by the Treatment Satisfaction Questionnaire for Medication and ACCEPT® questionnaire, was better overall for TIP compared with TIS and COLI. There were no unexpected adverse events and most were mild or moderate in intensity. Conclusion: The T-326 inhaler used to deliver TIP was easy to use, required shorter total administration time, and was much less frequently contaminated than the nebulizers. The safety findings observed for TIP were generally consistent with its established safety profile.

scholarly journals Epidemiology of first/new Pseudomonas aeruginosa infection in cystic fibrosis patients

2010 ◽  
Vol 9 ◽  
pp. S29 ◽  
Author(s):  
L. Zavataro ◽  
G. Taccetti ◽  
L. Cariani ◽  
N. Ravenni ◽  
G. Braccini ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Pseudomonas Aeruginosa ◽  
Pseudomonas Aeruginosa Infection

Epidemiology of Pseudomonas aeruginosa infection in cystic fibrosis and the use of strain genotyping

1993 ◽  
Vol 26 (3) ◽  
pp. 325-331 ◽  
Author(s):  
D.L. Smith ◽  
E.G. Smith ◽  
L.B. Gumery ◽  
D.E. Stableforth ◽  
L.M. Dalla Costa ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Pseudomonas Aeruginosa ◽  
Pseudomonas Aeruginosa Infection

scholarly journals Investigating the variation in the incidence of new Pseudomonas aeruginosa infection between paediatric cystic fibrosis centres

2017 ◽  
Vol 16 (5) ◽  
pp. e14-e16
Author(s):  
F.J. Gilchrist ◽  
A.M. Jones ◽  
A.R. Smyth ◽  
K.W. Southern ◽  
A.K. Webb ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Pseudomonas Aeruginosa ◽  
Pseudomonas Aeruginosa Infection
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