Antitussive Drugs

2012 ◽  
Keyword(s):  
Antitussive Drugs

Antitussive Drugs

2020 ◽  
pp. 1-5
Author(s):  
Clive P. Page
Keyword(s):  
Antitussive Drugs

scholarly journals The Assessment of Antitussive Drugs in Man

BMJ ◽  
1961 ◽  
Vol 1 (5233) ◽  
pp. 1149-1151 ◽  
Author(s):  
F. J. Prime
Keyword(s):  
Antitussive Drugs

Depression of cough reflex by microinjections of antitussive agents into caudal ventral respiratory group of the rabbit

2010 ◽  
Vol 109 (4) ◽  
pp. 1002-1010 ◽  
Author(s):  
Donatella Mutolo ◽  
Fulvia Bongianni ◽  
Elenia Cinelli ◽  
Tito Pantaleo
Keyword(s):  
Receptor Antagonist ◽  
Respiratory Activity ◽  
Neural Substrates ◽  
Cough Reflex ◽  
Ventral Respiratory Group ◽  
Tracheal Pressure ◽  
Site Of Action ◽  
A Site ◽  
Antitussive Agents ◽  
Antitussive Drugs

We have previously shown that the caudal nucleus tractus solitarii is a site of action of some antitussive drugs and that the caudal ventral respiratory group (cVRG) region has a crucial role in determining both the expiratory and inspiratory components of the cough motor pattern. These findings led us to suggest that the cVRG region, and possibly other neural substrates involved in cough regulation, may be sites of action of antitussive drugs. To address this issue, we investigated changes in baseline respiratory activity and cough responses to tracheobronchial mechanical stimulation following microinjections (30–50 nl) of some antitussive drugs into the cVRG of pentobarbital-anesthetized, spontaneously breathing rabbits. [d-Ala2, N-Me-Phe4,Gly5-ol]-enkephalin (DAMGO) and baclofen at the lower concentrations (0.5 mM and 0.1 mM, respectively) decreased cough number, peak abdominal activity, and peak tracheal pressure and increased cough-related total cycle duration (Tt). At the higher concentrations (5 mM and 1 mM, respectively), both drugs abolished the cough reflex. DAMGO and baclofen also affected baseline respiratory activity. Both drugs reduced peak abdominal activity, while only DAMGO increased Tt, owing to increases in expiratory time. The neurokinin-1 (NK1) receptor antagonist CP-99,994 (10 mM) decreased cough number, peak abdominal activity, and peak tracheal pressure, without affecting baseline respiration. The NK2 receptor antagonist MEN 10376 (5 mM) had no effect. The results indicate that the cVRG is a site of action of some antitussive agents and support the hypothesis that several neural substrates involved in cough regulation may share this characteristic.

scholarly journals EFFECTS OF SOME ANTITUSSIVE DRUGS ON THE ACTIVITIES OF THE AMBIGUOS NEURONS DURING COUGH REFLEX

1973 ◽  
Vol 23 ◽  
pp. 60
Author(s):  
Masahiro Mori ◽  
Yutaka Sakai ◽  
Takehiko Deguchi ◽  
Takao Hara
Keyword(s):  
Cough Reflex ◽  
Antitussive Drugs

Antiallergic and antitussive drugs

1990 ◽  
pp. 139-140
Author(s):  
F.A. Nelemans
Keyword(s):  
Antitussive Drugs

scholarly journals Effects of naloxone on the cough depressant activities of antitussive drugs.

1986 ◽  
Vol 87 (6) ◽  
pp. 641-648 ◽  
Author(s):  
Junzo KAMEI ◽  
Tomokazu HOSOKAWA ◽  
Saizo YANAURA ◽  
Takehiko HUKUHARA
Keyword(s):  
Antitussive Drugs

A categorical review on electroanalytical determination of non-narcotic over-the-counter abused antitussive drugs

Talanta ◽  
2015 ◽  
Vol 142 ◽  
pp. 157-163 ◽  
Author(s):  
Neeta Thapliyal ◽  
Harun Patel ◽  
Rajshekhar Karpoormath ◽  
Rajendra N. Goyal ◽  
Rajkumar Patel
Keyword(s):  
Over The Counter ◽  
Antitussive Drugs

Experimental Investigation of Nine Antitussive Drugs

1961 ◽  
Vol 50 (3) ◽  
pp. 216-221 ◽  
Author(s):  
P.L. Stefko ◽  
J. Denzel ◽  
I. Hickey
Keyword(s):  
Experimental Investigation ◽  
Antitussive Drugs
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