Michaelis-Menten kinetic analysis of the hepatic microsomal benzpyrene hydroxylase from control, phenobarbital- and methyl-3-cholanthrene-treated rats

1977 ◽  
Vol 16 (1) ◽  
pp. 23-38 ◽  
Author(s):  
Jean Cumps ◽  
Chehab Razzouk ◽  
Marcel B. Roberfroid
Keyword(s):  
Kinetic Analysis ◽  
Menten Kinetic ◽  
Benzpyrene Hydroxylase

Michaelis–Menten kinetic analysis of drugs of abuse to estimate their affinity to human P-glycoprotein

2013 ◽  
Vol 217 (2) ◽  
pp. 137-142 ◽  
Author(s):  
Markus R. Meyer ◽  
Tina Orschiedt ◽  
Hans H. Maurer
Keyword(s):  
Kinetic Analysis ◽  
Drugs Of Abuse ◽  
P Glycoprotein ◽  
Menten Kinetic

scholarly journals Michaelis-Menten kinetic analysis ofEscherichia coliSS142 adhesion to intestine 407 monolayers

1981 ◽  
Vol 12 (2) ◽  
pp. 99-103 ◽  
Author(s):  
Paul S. Cohen ◽  
Alan D. Elbein ◽  
Renate Solf ◽  
Helmut Mett ◽  
Janos Regös ◽  
...  
Keyword(s):  
Kinetic Analysis ◽  
Menten Kinetic

Kinetic Aspects of the Interaction of Blood Clotting Enzymes

1965 ◽  
Vol 13 (01) ◽  
pp. 155-175 ◽  
Author(s):  
H. C Hemker ◽  
P.W Hemker ◽  
E. A Loeliger
Keyword(s):  
Kinetic Analysis ◽  
Enzyme Kinetics ◽  
Blood Clotting ◽  
Enzyme System ◽  
Enzyme Kinetic ◽  
Clotting Time ◽  
Standard Methods

SummaryApplication of the methods of enzyme-kinetic analysis to the results of clotting tests is feasible and can yield useful results. However, the standard methods of enzyme kinetics are not applicable without modifications imposed by the peculiarities of the blood-clotting enzyme system. The influence of the following complicating circumstances is calculated :1. Substrate is not present in excess.2. Only relative measures exist for concentrations of substrate or enzymes.3. Enzymes and substrates are often added together.4. Reagents are not pure.5. Clotting-time is our only measure for clotting-velocity.Formulas are deduced, which makes it possible to recognize the effect of these complications.

Computer Simulation of Amperometric Biosensor Response to Mixtures of Compounds

2002 ◽  
Vol 7 (2) ◽  
pp. 3-14 ◽  
Author(s):  
R. Baronas ◽  
J. Christensen ◽  
F. Ivanauskas ◽  
J. Kulys
Keyword(s):  
Computer Simulation ◽  
Enzymatic Reaction ◽  
Diffusion Equations ◽  
Response Data ◽  
Finite Difference Technique ◽  
Stationary Diffusion ◽  
Biosensor Array ◽  
Menten Kinetic ◽  
Biosensor Response

A mathematical model of amperometric biosensors has been developed. The model bases on non-stationary diffusion equations containing a non-linear term related to Michaelis-Menten kinetic of the enzymatic reaction. The model describes the biosensor response to mixtures of multiple compounds in two regimes of analysis: batch and flow injection. Using computer simulation, large amount of biosensor response data were synthesised for calibration of a biosensor array to be used for characterization of wastewater. The computer simulation was carried out using the finite difference technique.

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