The interference of tricyclic antidepressants with the central hypotensive effect of clonidine

1973 ◽  
Vol 24 (3) ◽  
pp. 402-404 ◽  
Author(s):  
H.W. Van Spanning ◽  
P.A. Van Zwieten
1976 ◽  
Vol 51 (s3) ◽  
pp. 411s-413s ◽  
Author(s):  
P. A. Van Zwieten

1. In chloralose-anaesthetized cats the centrally induced hypotensive effect of clonidine, and in some cases α-methyldopa, was diminished by pretreatment with a variety of tricyclic antidepressants and neuroleptic agents. 2. The interaction is assumed to occur at the central α-adrenoreceptors. Clonidine or α-methylnoradrenaline (from α-methyldopa) are the agonists, and the aforementioned psychotropic drugs are the antagonists. 3. Psychotropic drugs which are not α-receptor blockers, like butyrophenone neuroleptics (pimozide and haloperidol) or benzodiazepine tranquillizers, do not significantly diminish the centrally induced hypotensive effect of clonidine.


1997 ◽  
Vol 42 (1) ◽  
pp. 84-84
Author(s):  
Terri Gullickson

1968 ◽  
Vol 59 (2) ◽  
pp. 227-234 ◽  
Author(s):  
H. C. Moore ◽  
I. Cserhati ◽  
F. P. Biliczki

ABSTRACT Experimental deciduomata and progesterone together lower the blood pressure in the steroid hypertensive rat from the 5th to 10th day of decidual growth i. e. from the 10th to 15th day of pseudopregnancy. This would suggest that the fall of blood pressure at an equivalent time of gestation in hypertensive pregnant rats could be due to the maternal decidua under the influence of progesterone. It is further considered that the metrial gland of the deciduoma is more likely to be responsible for the hypotensive effect and by comparison that the metrial gland is implicated in the hypotensive effect of pregnancy. Progesterone alone also exerts a minor hypotensive effect in those animals in which a nephrectomy forms part of the hypertension regimen and indicates one way in which a maternal renal factor could influence blood pressure responses in hypertensive pregnant rats.


Author(s):  
A.R. Vinogradov ◽  
◽  
B.G. Dzhashi ◽  
M.V. Morgatskaia ◽  
Y.S. Serkov ◽  
...  

Цель. Оценить гипотензивный эффект факоэмульсификации катаракты (ФЭК) у пациентов с ранее не оперированной открытоугольной глаукомой различных стадий. Материал и методы. Проведен анализ результатов ФЭК у 136 пациентов (136 глаз). Средний возраст пациентов 72±8,9 лет. ФЭК с имплантацией гибкой ИОЛ выполнялась по стандартной технологии тоннельным разрезом 2,0 мм на факоэмульсификаторах Infinity и Centurion Vision System.Пациенты были распределены на 3 группы: 1-ягруппа – I стадия, 2-я группа – II стадия, 3-я группа – III стадия глаукомы. Срок наблюдения 1 год. Результаты. В 1-й группе отмечалось снижение ВГД на срок наблюдения 1 год на 10% от исходного уровня: с 18,5±4,3 до 16,7±2,4 мм рт.ст. Во 2-й группе пациентов выявлено снижение ВГД с 18,4±4,5 до17,4±3,5 мм рт.ст. (на 7,6%). В 3-й группе отмечалось снижение ВГД с 19,8±4,1 до 18,3±2,3 мм рт.ст.(на 7,5%). Выводы. Выявлено достоверное снижение ВГД после выполнения ФЭК на глазах с начальной глаукомой. У пациентов с развитой и далекозашедшей стадией глаукомы гипотензивный эффект достоверно ниже.


Author(s):  
N Bobrova ◽  
N Trofimova

The aim of the work was to analyze the long-term results of using a temporary “liquid” implant in the surgery of congenital glaucoma in children. The basis of the developed method of filtrative antiglaucomatous surgery (Patent of Ukraine No. 45099 of 2009) – viscosinusotrabeculotomy – has been set the task of reducing the risk of developing intra- and postoperative complications, reducing the scarring rate and maintaining the newly created ways of the intraocular fluid outflow, which in general will increase the effectiveness of surgical treatment of congenital glaucoma in children. 54 children (91 eyes) with simple congenital glaucoma at the age of 1 to 36 months were operated on average (8.7 ± 8.2) months. The persistent and long-lasting hypotensive effect achieved due to viscosinusotrabeculotomy in children with developed and far-advanced stages of congenital glaucoma stops the processes of stretching of the membranes of the eye and stabilizes their size, which in general allows preserving and visual functions improving, in infancy – creating conditions for their formation.


2005 ◽  
Vol 60 (3) ◽  
pp. 253-257
Author(s):  
Juan Carlos PRIETO ◽  
Mónica QUEVEDO ◽  
Hugo F. MIRANDA ◽  
Gianni PINARDI
Keyword(s):  

2016 ◽  
Vol 12 (6) ◽  
pp. 560-567
Author(s):  
Marwa F. Mansour ◽  
Ehab F. El-Kady ◽  
Mona M. Abd El-Moety ◽  
Nabawia M. El-Guindi ◽  
Ann Van Schepdael ◽  
...  

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