Neurotrophic regulation of resting membrane potential and acetylcholine sensitivity in rat extensor digitorum longus muscle

1977 ◽  
Vol 57 (3) ◽  
pp. 766-791 ◽  
Author(s):  
T.N. Tiedt ◽  
P.Lewis Wisler ◽  
S.G. Younkin
Keyword(s):  
Membrane Potential ◽  
Extensor Digitorum Longus ◽  
Extensor Digitorum Longus Muscle ◽  
Extensor Digitorum ◽  
Resting Membrane Potential ◽  
Longus Muscle ◽  
Acetylcholine Sensitivity ◽  
Neurotrophic Regulation

Hyperpolarization of muscle by insulin in a glucose-free environment

1959 ◽  
Vol 197 (3) ◽  
pp. 524-526 ◽  
Author(s):  
Kenneth L. Zierler
Keyword(s):  
Membrane Potential ◽  
Glucose Uptake ◽  
Extensor Digitorum Longus ◽  
Potassium Concentration ◽  
Extensor Digitorum ◽  
Muscle Membrane ◽  
Resting Membrane Potential ◽  
Free Solution ◽  
Longus Muscle ◽  
Free Environment

In a glucose-free solution, insulin increased resting membrane potential of rat extensor digitorum longus muscle by as much as it had in the presence of glucose. Even in the absence of glucose there was probably net accumulation of potassium by muscle, but the increase in muscle potassium concentration was too small to have been the cause of the observed hyperpolarization. It is concluded that insulin hyperpolarizes muscle membrane, as a result of which potassium moves into muscle, and that the eventual effect of insulin on potassium movement can be independent of any effect insulin may also have on glucose uptake.

Effect of insulin on membrane potential and potassium content of rat muscle

1959 ◽  
Vol 197 (3) ◽  
pp. 515-523 ◽  
Author(s):  
Kenneth L. Zierler
Keyword(s):  
Membrane Potential ◽  
Extensor Digitorum Longus ◽  
Extensor Digitorum ◽  
Potassium Content ◽  
Resting Membrane Potential ◽  
Extracellular Potassium ◽  
Conventional Theory ◽  
Rat Muscle

Insulin increased resting membrane potential of excised rat muscle, extensor digitorum longus, by about 5 mv in less than 1 hour. In 1 hour insulin caused no increase in the ratio of intra- to extracellular potassium, but in 2–3 hours intracellular K increased by about 10%. It is concluded that the increase in intracellular K is probably too small and too late to account for the hyperpolarization on the basis of conventional theory and it is suggested that the hyperpolarization produced by insulin is the cause of the potassium shift.

The effect of adenosine deaminase on insulin sensitivity in the extensor digitorum longus muscle of the rat

1986 ◽  
Vol 14 (2) ◽  
pp. 328-329 ◽  
Author(s):  
FRED J. LOZEMAN ◽  
BRENDAN LEIGHTON ◽  
R. A. JOHN CHALLISS ◽  
SIMON A. OWEN ◽  
ERIC A. NEWSHOLME
Keyword(s):  
Insulin Sensitivity ◽  
Adenosine Deaminase ◽  
Extensor Digitorum Longus ◽  
Extensor Digitorum Longus Muscle ◽  
Extensor Digitorum ◽  
Longus Muscle
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