Stimulation of hypertrophic growth of cultured neonatal rat heart cells through type 1 angiotensin II receptor

1992 ◽  
Vol 24 ◽  
pp. 243
Author(s):  
Setsuya Miyata ◽  
Takashi Haneda ◽  
Jun Fukuzawa ◽  
Kiyotaka Okamoto ◽  
Hiroki Takeda ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Rat Heart ◽  
Neonatal Rat ◽  
Heart Cells ◽  
Angiotensin Ii Receptor ◽  
Hypertrophic Growth ◽  
Neonatal Rat Heart ◽  
Rat Heart Cells ◽  
Stimulation Of

Taurine Improves Angiotensin II-Induced Hypertrophy of Cultured Neonatal Rat Heart Cells

1998 ◽  
pp. 129-135 ◽  
Author(s):  
Kyoko Takahahsi ◽  
Mitsuhiro Azuma ◽  
Akemichi Baba ◽  
Stephen Schaffer ◽  
Junichi Azuma
Keyword(s):  
Angiotensin Ii ◽  
Rat Heart ◽  
Neonatal Rat ◽  
Heart Cells ◽  
Neonatal Rat Heart ◽  
Rat Heart Cells

Hypertrophic growth of cultured neonatal rat heart cells mediated by type 1 angiotensin II receptor

1994 ◽  
Vol 266 (6) ◽  
pp. H2443-H2451 ◽  
Author(s):  
S. Miyata ◽  
T. Haneda
Keyword(s):  
Protein Kinase C ◽  
Angiotensin Ii ◽  
Protein Kinase ◽  
Neonatal Rat ◽  
Heart Cells ◽  
Ang Ii ◽  
Angiotensin Ii Receptor ◽  
Hypertrophic Growth ◽  
Kinase C

Primary cultures of neonatal cardiac myocytes were used to determine the identity of second messengers that are involved in angiotensin II (ANG II) receptor-mediated effects on cardiac hypertrophy and the type of ANG II receptor that is involved in ANG II-induced cell growth. Treatment of myocytes with ANG II significantly increased the protein-to-DNA and the RNA-to-DNA ratios. ANG II accelerated rates of protein synthesis by 24.9%. Intracellular free calcium was transiently increased after ANG II exposure. The activity of protein kinase C in particulate fractions was transiently increased after exposure to ANG II but returned to control level. The activity of protein kinase C in the cytosol was significantly decreased at all times after exposure to ANG II. After ANG II treatment, the content of c-Fos mRNA was increased. The stimulatory effects of ANG II on these parameters were inhibited by the type 1 angiotensin II receptor (AT1) antagonist, losartan. These studies demonstrate that ANG II-induced hypertrophic growth is, at least in part, mediated through AT1 receptors.

Lovastatin prevents angiotensin II-induced cardiac hypertrophy in cultured neonatal rat heart cells

1999 ◽  
Vol 376 (1-2) ◽  
pp. 139-148 ◽  
Author(s):  
Shinji Oi ◽  
Takashi Haneda ◽  
Junzo Osaki ◽  
Yusuke Kashiwagi ◽  
Yasuhiro Nakamura ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Cardiac Hypertrophy ◽  
Rat Heart ◽  
Neonatal Rat ◽  
Heart Cells ◽  
Neonatal Rat Heart ◽  
Rat Heart Cells

Hypertrophic growth of cultured neonatal rat heart cells mediated by vasopressin V1A receptor

2000 ◽  
Vol 391 (1-2) ◽  
pp. 39-48 ◽  
Author(s):  
Yasuhiro Nakamura ◽  
Takashi Haneda ◽  
Junzo Osaki ◽  
Setsuya Miyata ◽  
Kenjiro Kikuchi
Keyword(s):  
Rat Heart ◽  
Neonatal Rat ◽  
Heart Cells ◽  
Hypertrophic Growth ◽  
V1a Receptor ◽  
Neonatal Rat Heart ◽  
Vasopressin V1a Receptor ◽  
Rat Heart Cells

Chronotropic effect of histamine on cultured neonatal rat heart cells

1979 ◽  
Vol 58 (2) ◽  
pp. 117-123 ◽  
Author(s):  
Klara Csete ◽  
Marie-Claude Auclair ◽  
Paul Lechat
Keyword(s):  
Rat Heart ◽  
Neonatal Rat ◽  
Heart Cells ◽  
Chronotropic Effect ◽  
Neonatal Rat Heart ◽  
Rat Heart Cells
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