Milwaukee shoulder syndrome: Eleven additional cases with involvement of the knee in seven (basic calcium phosphate crystal deposition disease)

1984 ◽  
Vol 14 (1) ◽  
pp. 36-44 ◽  
Author(s):  
Paul B. Halverson ◽  
Daniel J. McCarty ◽  
Herman S. Cheung ◽  
Lawrence M. Ryan
Author(s):  
Nicola Dalbeth

Basic calcium phosphate (BCP) crystals deposit within periarticular and articular sites, leading to a variety of clinical presentations. The most well-recognized clinical syndromes associated with BCP crystal deposition are calcific tendinitis and BCP crystal-associated destructive arthritis such as Milwaukee shoulder syndrome. There is emerging evidence that BCP crystals also play a role in osteoarthritis pathogenesis. Within the joint, tissue responses to BCP crystals include induction of pro-catabolic and inflammatory pathways. Clinical management of BCP crystal-associated arthropathies is limited by the lack of reliable and feasible methods to detect crystals, and the current unavailability of systemic therapies that promote BCP crystal dissolution.


2010 ◽  
Vol 62 (9) ◽  
pp. 2829-2830 ◽  
Author(s):  
Christelle Nguyen ◽  
Hang-Korng Ea ◽  
Dominique Bazin ◽  
Michel Daudon ◽  
Frédéric Lioté

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