Metabolic activation of nitrodibenzofurans by rat liver in Salmonella/mutagenicity test

1994 ◽  
Vol 325 (1) ◽  
pp. 11-19 ◽  
Author(s):  
Tetsushi Watanabe ◽  
Hideaki Kaji ◽  
Terue Kasai ◽  
Teruhisa Hirayama
Keyword(s):  
Rat Liver ◽  
Metabolic Activation ◽  
Mutagenicity Test

scholarly journals CL 64, 855, a potent do anti-Trypanosoma cruzi drug, is also mutagenic in the salmonella/microsome assay

1986 ◽  
Vol 81 (1) ◽  
pp. 49-52 ◽  
Author(s):  
R. C. C. Ferreira ◽  
L. C. S. Ferreira
Keyword(s):  
Trypanosoma Cruzi ◽  
Salmonella Typhimurium ◽  
Rat Liver ◽  
Metabolic Activation ◽  
Mutagenic Action ◽  
Short Term ◽  
Mutagenicity Test

The nitroimidazole-tiadiazole derivative CL 64,855 (2-amino-5-(1-methyl-5-nitro-2-imidazolyl)-1,3,4-thiadiazole, a potent anti-trypanosomal drug, was assayed in a short-term bacterial mutagenicity test with Salmonella typhimurium strains TA 98, TA 100 and TA 102. Results indicate that CL 64,855 is a potent frameshift mutagen detected by strains TA 98 and TA 102. CL 64,855 was able to revert the indicators strains at concentrations as low as 0.1 µg/plate. Metabolic activation experiments with rat liver microsomal fractions did not increase the mutagenic action of Cl 64,855.

Metabolic Activation of Procarcinogens to Genotoxic Products in Cultured Rat Liver Cells

Pathobiology ◽  
1984 ◽  
Vol 52 (6) ◽  
pp. 355-360
Author(s):  
G L. Murison ◽  
S D. Hall ◽  
A M. Lee
Keyword(s):  
Rat Liver ◽  
Metabolic Activation ◽  
Liver Cells ◽  
Rat Liver Cells

The role of metabolic activation by cytochrome P-450 in covalent binding of VP 16-213 to rat liver and HeLa cell microsomal proteins

1985 ◽  
Vol 21 (9) ◽  
pp. 1099-1106 ◽  
Author(s):  
J.M.S. van Maanen ◽  
C. de Ruiter ◽  
J. de Vries ◽  
P.R. Kootstra ◽  
F. Gobas ◽  
...  
Keyword(s):  
Hela Cell ◽  
Rat Liver ◽  
Covalent Binding ◽  
Metabolic Activation ◽  
Cytochrome P 450

Metabolic activation of hydralazine by rat liver microsomes

1987 ◽  
Vol 36 (16) ◽  
pp. 2667-2672 ◽  
Author(s):  
Lynn B. LaCagnin ◽  
Howard D. Colby ◽  
Naresh S. Dalal ◽  
John P. O'Donnell
Keyword(s):  
Rat Liver ◽  
Liver Microsomes ◽  
Metabolic Activation ◽  
Rat Liver Microsomes

Metabolic activation of 1,2,4-trichlorobenzene and pentachlorobenzene by rat liver microsomes: A major role for quinone metabolites

1991 ◽  
Vol 108 (2) ◽  
pp. 223-233 ◽  
Author(s):  
Cathaline den Besten ◽  
Marjan C.C. Smink ◽  
Erik J. de Vries ◽  
Peter J. van Bladeren
Keyword(s):  
Rat Liver ◽  
Liver Microsomes ◽  
Metabolic Activation ◽  
Rat Liver Microsomes
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