CL 64, 855, a potent do anti-Trypanosoma cruzi drug, is also mutagenic in the salmonella/microsome assay
1986 ◽
Vol 81
(1)
◽
pp. 49-52
◽
Keyword(s):
The nitroimidazole-tiadiazole derivative CL 64,855 (2-amino-5-(1-methyl-5-nitro-2-imidazolyl)-1,3,4-thiadiazole, a potent anti-trypanosomal drug, was assayed in a short-term bacterial mutagenicity test with Salmonella typhimurium strains TA 98, TA 100 and TA 102. Results indicate that CL 64,855 is a potent frameshift mutagen detected by strains TA 98 and TA 102. CL 64,855 was able to revert the indicators strains at concentrations as low as 0.1 µg/plate. Metabolic activation experiments with rat liver microsomal fractions did not increase the mutagenic action of Cl 64,855.
1978 ◽
Vol 1
(5)
◽
pp. 301-309
◽
Keyword(s):
1994 ◽
Vol 325
(1)
◽
pp. 11-19
◽
1985 ◽
Vol 156
(1-2)
◽
pp. 53-59
◽
Keyword(s):
1996 ◽
Vol 59
(3)
◽
pp. 244-248
◽
1992 ◽
Vol 272
(2)
◽
pp. 183-192
◽
Keyword(s):
1978 ◽
Vol 253
(14)
◽
pp. 4944-4950