Quantitative vasoconstrictor assay for topical corticosteroids: The puzzling case of fluocinolone acetonide

1993 ◽  
Vol 29 (2) ◽  
pp. 197-202 ◽  
Author(s):  
Jere D. Guin ◽  
Mark S. Wallis ◽  
Robert Walls ◽  
Paul A. Lehman ◽  
Thomas J. Franz
Keyword(s):  
Fluocinolone Acetonide ◽  
Topical Corticosteroids ◽  
Vasoconstrictor Assay

THE THYMOLYTIC ACTIVITY OF 6- AND 9-HALOCORTICOIDS AND RELATED STEROIDS

1965 ◽  
Vol 49 (2) ◽  
pp. 262-270 ◽  
Author(s):  
Ralph I. Dorfman ◽  
P. G. Holton ◽  
Fred A. Kind
Keyword(s):  
Double Bond ◽  
Subcutaneous Injection ◽  
Fluocinolone Acetonide ◽  
Relative Potency ◽  
Subcutaneous Route ◽  
Adrenalectomized Rats

ABSTRACT Adrenalectomized rats were used for the determination of the relative potency of various 6- and 9-halo substituted corticoids administered subcutaneously or by gavage using thymus weightas the endpoint. By subcutaneous injection, fluocinolone acetonide was the most active corticoid at 700 times that of cortisol. This compound was also the most active corticoid by the gavage route and was judged to be 570 times as active as the standard cortisol. The introduction of the 16,17-acetonide and 16,17-acetone 21-acetate groups into 17α,21-dihydroxy-9α,11β-dichloropregna-1,4-diene-3,20-dione increased the activity by a factor of 42 and 100, respectively. The introduction of the δ1 double bond into 6α-fluoroprogesterone 16,17-acetonide caused an increase of 10-fold in thymolytic activity assessed by the subcutaneous route

Studies on Adrenocortical Suppression Following Percutaneous Absorption of Topical Corticosteroids

1973 ◽  
Vol 35 (4) ◽  
pp. 472-476 ◽  
Author(s):  
Shuhei SHIMAO ◽  
Yasuyuki SHIMIZU ◽  
Motoyuki MIHARA ◽  
Toshiaki USUI ◽  
Hiroko KAWAMOTO
Keyword(s):  
Percutaneous Absorption ◽  
Topical Corticosteroids
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