scholarly journals In-vitro exposure of guinea pig main bronchi to 2·5 ppm of nitrogen dioxide does not alter airway smooth muscle response

1995 ◽  
Vol 89 (5) ◽  
pp. 323-328 ◽  
Author(s):  
P. Chitano ◽  
R.E. Lucchini ◽  
E. Coser ◽  
A. Papi ◽  
M. Saetta ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Guinea Pig ◽  
Nitrogen Dioxide ◽  
Airway Smooth Muscle ◽  
Muscle Response ◽  
In Vitro Exposure

Viral infection increases contractile but not secretory responses to substance P in ferret trachea

1992 ◽  
Vol 72 (2) ◽  
pp. 608-611 ◽  
Author(s):  
T. C. Murray ◽  
D. B. Jacoby
Keyword(s):  
Smooth Muscle ◽  
Substance P ◽  
Viral Infection ◽  
Airway Smooth Muscle ◽  
Neutral Endopeptidase ◽  
Secretory Response ◽  
Muscle Response ◽  
Endopeptidase Activity ◽  
In Vitro Effects

Viral infection increases the airway smooth muscle response to substance P. This effect is due to decreased activity of neutral endopeptidase (EC 3.4.24.11), an enzyme that degrades substance P. Inhibition of neutral endopeptidase activity also potentiates substance P-induced 35SO4-labeled macromolecule secretion. Therefore we examined the in vitro effects of substance P on 35SO4-macromolecule secretion from the tracheae of influenza-infected ferrets. Despite a virus-induced loss of neutral endopeptidase activity (demonstrated in muscle bath experiments), there was no difference between control and infected tracheae in either baseline secretion [697 +/- 125 vs. 579 +/- 67 (SE) cpm/15 min; n = 15 tissues) or in the response to 10(-6) M substance P (increased by 218 +/- 63 and 195 +/- 51, respectively) or 10(-5) M substance P (increased by 416 +/- 95 and 354 +/- 54, respectively). Although phosphoramidon (10(-6) M) potentiated the secretory response to substance P, there was again no difference between control and infected tracheae. These data show that although viral infection decreases airway neutral endopeptidase activity, virus-induced hypersecretion is not due to a resulting increase in the secretory response to substance P.

In Vitro Exposure to Nitrogen Dioxide (NO2) Does Not Alter Bronchial Smooth Muscle Responsiveness in Ovalbumin-sensitized Guinea-pigs

1994 ◽  
Vol 7 (4) ◽  
pp. 251-257 ◽  
Author(s):  
P. Chitano ◽  
E. Coser ◽  
R.E. Lucchini ◽  
A. Papi ◽  
M. Saetta ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Nitrogen Dioxide ◽  
Guinea Pigs ◽  
Bronchial Smooth Muscle ◽  
In Vitro Exposure

scholarly journals Isotonic smooth muscle response in human bronchi exposed in vitro to nitrogen dioxide

1996 ◽  
Vol 9 (11) ◽  
pp. 2294-2297 ◽  
Author(s):  
P. Chitano ◽  
R.E. Lucchini ◽  
F. Calabrò ◽  
M. Saetta ◽  
P. Maestrelli ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Nitrogen Dioxide ◽  
Muscle Response ◽  
Human Bronchi

Tachyphylaxis to β-adrenoceptor agonists in guinea pig airway smooth muscle in vivo and in vitro

1977 ◽  
Vol 42 (3) ◽  
pp. 195-205 ◽  
Author(s):  
James S. Douglas ◽  
Alan J. Lewis ◽  
Pamela Ridgway ◽  
Charles Brink ◽  
Arend Bouhuys
Keyword(s):  
Smooth Muscle ◽  
Guinea Pig ◽  
Airway Smooth Muscle ◽  
Adrenoceptor Agonists
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