Monoclonal Antibodies to Human Mammary Carcinoma Cells

1984 ◽  
pp. 1017-1020 ◽  
Author(s):  
S. KAUL ◽  
G. BASTERT ◽  
D. DRAHOVSKY ◽  
A. WACKER
Keyword(s):  
Monoclonal Antibodies ◽  
Mammary Carcinoma ◽  
Carcinoma Cells ◽  
Human Mammary Carcinoma ◽  
Mammary Carcinoma Cells

scholarly journals From The Cover: Phenotypic conversion of human mammary carcinoma cells by autocrine human growth hormone

2004 ◽  
Vol 101 (42) ◽  
pp. 15166-15171 ◽  
Author(s):  
S. Mukhina ◽  
H. C. Mertani ◽  
K. Guo ◽  
K.-O. Lee ◽  
P. D. Gluckman ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Human Growth Hormone ◽  
Mammary Carcinoma ◽  
Human Growth ◽  
Carcinoma Cells ◽  
Human Mammary Carcinoma ◽  
Mammary Carcinoma Cells

Signal Transducer and Activator of Transcription (STAT)-5A and STAT5B Differentially Regulate Human Mammary Carcinoma Cell Behavior

Endocrinology ◽  
2010 ◽  
Vol 151 (1) ◽  
pp. 43-55 ◽  
Author(s):  
Jian-Zhong Tang ◽  
Ze-Hua Zuo ◽  
Xiang-Jun Kong ◽  
Michael Steiner ◽  
Zhinan Yin ◽  
...  
Keyword(s):  
Cell Motility ◽  
Mammary Carcinoma ◽  
Carcinoma Cell ◽  
Carcinoma Cells ◽  
Signal Transducer ◽  
Human Mammary Carcinoma ◽  
Anchorage Independent Growth ◽  
Human Mammary Carcinoma Cell ◽  
Mammary Carcinoma Cells ◽  
Interfering Rna

Abstract Increased activation of signal transducer and activator of transcription (STAT)-5 has been reported in various malignancies including mammary carcinoma. However, it is only recently that potentially distinct roles of STAT5A and STAT5B in neoplasia have begun to emerge. Herein we systematically delineate the functions of STAT5A and STAT5B in human mammary carcinoma cell lines MCF-7 and T47D. Forced expression of constitutively active (CA) STAT5A enhanced both survival and anchorage-independent growth of human mammary carcinoma cells but concordantly suppressed cell motility as revealed in colony scattering, cell migration, and invasion assays. In contrast, forced expression of CA STAT5B exhibited lower potency than CA STAT5A in enhancing survival and anchorage-independent growth of mammary carcinoma cells and exerted no effects on cell motility. Differential expression of genes that regulate cellular survival and motility was concomitantly observed on forced expression of CA STAT5A or CA STAT5B. Small interfering RNA-mediated depletion of STAT5A significantly impaired anchorage-independent growth of human mammary carcinoma cells, whereas a smaller reduction was observed upon small interfering RNA-mediated depletion of STAT5B. Depletion of endogenous STAT5A also significantly enhanced cell motility, whereas depletion of endogenous STAT5B exhibited no effect. Xenograft studies provided data concordant with the in vitro effects of the two STAT5 isoforms. We therefore demonstrate that STAT5A and STAT5B differentially regulate behavior of human mammary carcinoma cells.

In Vitro Growth Promotion of Human Mammary Carcinoma Cells by Steroid Hormones, Tamoxifen, and Prolactin23

1984 ◽  
Vol 73 (2) ◽  
pp. 313-321 ◽  
Author(s):  
Wolfgang E. Simon ◽  
Michael Albrecht ◽  
Günter Trams ◽  
Manfred Dietel ◽  
Fritz Hölzel
Keyword(s):  
Steroid Hormones ◽  
Mammary Carcinoma ◽  
Growth Promotion ◽  
Carcinoma Cells ◽  
In Vitro Growth ◽  
Human Mammary Carcinoma ◽  
Mammary Carcinoma Cells

Alteratioon in proliferative and endocrine responsiveness of human mammary carcinoma cells by prototypic tumor-suppressing agents

Steroids ◽  
1993 ◽  
Vol 58 (5) ◽  
pp. 215-219 ◽  
Author(s):  
Akihiko Suto ◽  
H.Leon Bradlow ◽  
Tetsuro Kubota ◽  
Masaki Kitajima ◽  
George Y. Wong ◽  
...  
Keyword(s):  
Mammary Carcinoma ◽  
Carcinoma Cells ◽  
Human Mammary Carcinoma ◽  
Mammary Carcinoma Cells

scholarly journals The Efficacy of Methotrexate-Impregnated Hydroxyapatite Composites on Human Mammary Carcinoma Cells

2007 ◽  
Vol 15 (1) ◽  
pp. 56-61 ◽  
Author(s):  
J Vechasilp ◽  
B Tangtrakulwanich ◽  
K Oungbho ◽  
S Yuenyongsawad
Keyword(s):  
Mammary Carcinoma ◽  
Carcinoma Cells ◽  
Human Mammary Carcinoma ◽  
Mammary Carcinoma Cells
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