CHARACTERIZATION OF THE CYTOCHROME P-450-CONTAINING MIXED FUNCTION OXIDASE SYSTEM OF RAT COLON

1980 ◽  
pp. 1177-1180
Author(s):  
H.W. Strobel ◽  
W.F. Fang ◽  
R.J. Oshinsky
Keyword(s):  
Rat Colon ◽  
Mixed Function Oxidase ◽  
Oxidase System ◽  
Mixed Function Oxidase System ◽  
Cytochrome P 450

Occurrence of a cytochrome P-450-containing mixed-function oxidase system in the pond snail,Lymnaea stagnalis

Xenobiotica ◽  
1991 ◽  
Vol 21 (2) ◽  
pp. 223-233 ◽  
Author(s):  
M. Wilbrink ◽  
E. J. Groot ◽  
R. Jansen ◽  
Y. De Vries ◽  
N. P. E. Vermeulen
Keyword(s):  
Lymnaea Stagnalis ◽  
Pond Snail ◽  
Mixed Function Oxidase ◽  
Oxidase System ◽  
Mixed Function Oxidase System ◽  
Cytochrome P 450

Use of monoclonal antibodies to characterize the induction response of the cytochrome P-450-dependent mixed function oxidase system to nitrofluoranthenes

1987 ◽  
Vol 8 (11) ◽  
pp. 1679-1684 ◽  
Author(s):  
Wasiuddin A. Khan ◽  
Parthasarathy Asokan ◽  
Sang S. Park ◽  
Harry V. Gelboin ◽  
David R. Bickers ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Mixed Function Oxidase ◽  
Oxidase System ◽  
Mixed Function Oxidase System ◽  
Cytochrome P 450

Regulation of hepatic cytochrome P-450 during Infectious disease

1990 ◽  
Vol 68 (6) ◽  
pp. 777-781 ◽  
Author(s):  
Kenneth W. Renton ◽  
Leah C. Knickle
Keyword(s):  
Infectious Disease ◽  
Viral Infections ◽  
Oligonucleotide Probe ◽  
Protein S ◽  
Unique Sequence ◽  
Mixed Function Oxidase ◽  
Oxidase System ◽  
Mixed Function Oxidase System ◽  
Cytochrome P 450 ◽  
Hepatic Cytochrome

During episodes of infectious disease the mixed function oxidase system is depressed and the capacity of the liver to metabolize drags can be compromised in both animals and humans. The depression that occurs during viral infections is mediated via the production of interferon. This action of interferon requires the synthesis of an intermediate protein(s) yet to be identified. Using an oligonucleotide probe for a unique sequence in cytochrome P-450LAω we have now shown that the mRNA for this isozyme is depressed following the administration of interferon inducers. The magnitude in the loss of mRNA corresponds to the magnitude of the loss in the levels of this isozyme. This depression is observed within 6 h of interferon exposure. It is concluded that the decrease in drag metabolism during viral infections is caused by an interferon-mediated loss in mRNA and subsequent cytochrome P-450 synthesis in the liver.Key words: cytochrome P-450, drug metabolism, mixed function oxidase, interferon, viral infection.

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