Poster 279: Changes of Somatosensory Evoked Potential Study Following Functional Improvement in Patients With Incomplete Spinal Cord Injury

2007 ◽  
Vol 88 (9) ◽  
pp. E91-E92
Author(s):  
Yong Rae Kim ◽  
Ki Ho Cho ◽  
Sung Hyun Kim
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Evoked Potential ◽  
Somatosensory Evoked Potential ◽  
Functional Improvement ◽  
Incomplete Spinal Cord Injury ◽  
Potential Study ◽  
Cord Injury

scholarly journals Evaluation of Somatosensory Evoked Potential and Pain Rating Index in a Patient with Spinal Cord Injury Accepted Cell Therapy

2016 ◽  
Vol 4;19 (4;5) ◽  
pp. E659-E666
Author(s):  
Yihua An
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Neuropathic Pain ◽  
Umbilical Cord ◽  
Evoked Potential ◽  
Somatosensory Evoked Potential ◽  
Pain Rating ◽  
Sensory Pathways ◽  
Cord Injury ◽  
Pain Rating Index

Spinal cord injury (SCI) causes a high incidence of motor and sensory dysfunctions accompanied with neuropathic pain. No effective treatment is available. Both somatosensory evoked potential (SSEP) and neuropathic pain (NPP) are transmitted via myelinated large diameter fibers of deep sensory pathways. Here we aimed to evaluate whether SSEP can consistently and objectively assess transmission of deep sensory pathways, and to examine the effects of umbilical cord mesenchymal stem cell (UCMSC) transplantation on SSEP and NPP as assessed by the pain rating index (PRI) in a patient with a 2-year history of complete cervical SCI. We demonstrate that SSEP can directly reflect physiological function of myelinated large fibers in deep sensory pathway transmission (NPP is also transmitted by the same pathway). One year after UCMSC transplantation, the SSEP parameter, PRI, and clinical presentations of NPP significantly improved. Key words: Spinal cord, neuropathic pain, somatosensory evoked potential, umbilical cord mesenchymal stem cells

scholarly journals Operant conditioning of the motor-evoked potential and locomotion in people with and without chronic incomplete spinal cord injury

2019 ◽  
Vol 121 (3) ◽  
pp. 853-866 ◽  
Author(s):  
Aiko K. Thompson ◽  
Gina Fiorenza ◽  
Lindsay Smyth ◽  
Briana Favale ◽  
Jodi Brangaccio ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Operant Conditioning ◽  
Motor Function ◽  
Evoked Potential ◽  
Motor Evoked Potential ◽  
Incomplete Spinal Cord Injury ◽  
Function Recovery ◽  
Cord Injury ◽  
Ankle Dorsiflexor

Foot drop is very common among people with chronic incomplete spinal cord injury (SCI) and likely stems from SCI that disturbs the corticospinal activation of the ankle dorsiflexor tibialis anterior (TA). Thus, if one can recover or increase the corticospinal excitability reduced by SCI, motor function recovery may be facilitated. Here, we hypothesized that in people suffering from weak dorsiflexion due to chronic incomplete SCI, increasing the TA motor-evoked potential (MEP) through operant up-conditioning can improve dorsiflexion during locomotion, while in people without any injuries, it would have little impact on already normal locomotion. Before and after 24 MEP conditioning or control sessions, locomotor electromyography (EMG) and kinematics were measured. This study reports the results of these locomotor assessments. In participants without SCI, locomotor EMG activity, soleus Hoffmann reflex modulation, and joint kinematics did not change, indicating that MEP up-conditioning or repeated single-pulse transcranial magnetic stimulation (i.e., control protocol) does not influence normal locomotion. In participants with SCI, MEP up-conditioning increased TA activity during the swing-to-swing stance transition phases and ankle joint motion during locomotion in the conditioned leg and increased walking speed consistently. In addition, the swing-phase TA activity and ankle joint motion also improved in the contralateral leg. The results are consistent with our hypothesis. Together with the previous operant conditioning studies in humans and rats, the present study suggests that operant conditioning can be a useful therapeutic tool for enhancing motor function recovery in people with SCI and other central nervous system disorders. NEW & NOTEWORTHY This study examined the functional impact of operant conditioning of motor-evoked potential (MEP) to transcranial magnetic stimulation that aimed to increase corticospinal excitability for the ankle dorsiflexor tibialis anterior (TA). In people with chronic incomplete spinal cord injury (SCI), MEP up-conditioning increased TA activity and improved dorsiflexion during locomotion, while in people without injuries, it had little impact on already normal locomotion. MEP conditioning may potentially be used to enhance motor function recovery after SCI.

scholarly journals Hemisection spinal cord injury in rat: The value of intraoperative somatosensory evoked potential monitoring

2012 ◽  
Vol 211 (2) ◽  
pp. 179-184 ◽  
Author(s):  
Beth A. Cloud ◽  
Bret G. Ball ◽  
Bingkun K. Chen ◽  
Andrew M. Knight ◽  
Jeffrey S. Hakim ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Evoked Potential ◽  
Somatosensory Evoked Potential ◽  
Cord Injury ◽  
Evoked Potential Monitoring ◽  
Potential Monitoring
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