Evidence supporting the role of calpain in the α-processing of amyloid-β precursor protein

2012 ◽  
Vol 420 (3) ◽  
pp. 530-535 ◽  
Author(s):  
Huey T. Nguyen ◽  
Darrell R. Sawmiller ◽  
Qi Wu ◽  
Jerome J. Maleski ◽  
Ming Chen
Keyword(s):  
Amyloid Β ◽  
Precursor Protein

Novel heparan sulphate analogues: inhibition of β-secretase cleavage of amyloid precursor protein

2005 ◽  
Vol 33 (5) ◽  
pp. 1116-1118 ◽  
Author(s):  
S.J. Patey ◽  
E.A. Yates ◽  
J.E. Turnbull
Keyword(s):  
Amyloid Precursor Protein ◽  
Heparan Sulphate ◽  
Amyloid Β ◽  
Precursor Protein ◽  
Amyloid Β Peptide ◽  
Neuritic Plaques ◽  
Rate Limiting Step ◽  
Aβ Amyloid ◽  
Ad Alzheimer’S Disease

The role of HS (heparan sulphate) in the pathology of AD (Alzheimer's disease) is multifaceted. HS and other glycosaminoglycans have been widely reported to be associated with neuritic plaques. HS has also been shown to promote the aggregation of Aβ (amyloid β-peptide), the proteinaceous component of neuritic plaques. Recently, we described a novel and contrasting role for HS in the pathology of AD: HS can inhibit the formation of Aβ, by directly interacting with the protease BACE1 (β-site amyloid precursor protein cleaving enzyme 1; β-secretase 1), that cleaves the amyloid precursor protein and is the rate limiting step in the generation of Aβ. Here, we review the current roles of HS and the potential for HS-derivatives in the treatment of AD.

Amyloidogenic Processing of Amyloid Precursor Protein: Evidence of a Pivotal Role of Glutaminyl Cyclase in Generation of Pyroglutamate-Modified Amyloid-β†

Biochemistry ◽  
2008 ◽  
Vol 47 (28) ◽  
pp. 7405-7413 ◽  
Author(s):  
Holger Cynis ◽  
Eike Scheel ◽  
Takaomi C. Saido ◽  
Stephan Schilling ◽  
Hans-Ulrich Demuth
Keyword(s):  
Amyloid Precursor Protein ◽  
Amyloid Β ◽  
Precursor Protein ◽  
Pivotal Role ◽  
Glutaminyl Cyclase ◽  
Amyloidogenic Processing

The role of the protein glycosylation state in the control of cellular transport of the amyloid β precursor protein

Neuroscience ◽  
1999 ◽  
Vol 90 (1) ◽  
pp. 15-25 ◽  
Author(s):  
I McFarlane ◽  
N Georgopoulou ◽  
C.M Coughlan ◽  
A.M Gillian ◽  
K.C Breen
Keyword(s):  
Amyloid Β ◽  
Protein Glycosylation ◽  
Precursor Protein ◽  
Cellular Transport

scholarly journals Novel Role of RanBP9 in BACE1 Processing of Amyloid Precursor Protein and Amyloid β Peptide Generation

2009 ◽  
Vol 284 (18) ◽  
pp. 11863-11872 ◽  
Author(s):  
Madepalli K. Lakshmana ◽  
Il-Sang Yoon ◽  
Eunice Chen ◽  
Elizabetta Bianchi ◽  
Edward H. Koo ◽  
...  
Keyword(s):  
Amyloid Precursor Protein ◽  
Amyloid Β ◽  
Precursor Protein ◽  
Amyloid Β Peptide

Role of acetylcholinesterase inhibitors in the regulation of amyloid β precursor protein (AβPP) metabolism

2005 ◽  
Vol 157-158 ◽  
pp. 335-338 ◽  
Author(s):  
Marco Racchi ◽  
Michela Mazzucchelli ◽  
S. Carolina Lenzken ◽  
Emanuela Porrello ◽  
Cristina Lanni ◽  
...  
Keyword(s):  
Amyloid Β ◽  
Acetylcholinesterase Inhibitors ◽  
Precursor Protein

A possible role of glycation in the regulation of amyloid β precursor protein processing leading to amyloid β accumulation

2020 ◽  
Vol 142 ◽  
pp. 109799
Author(s):  
Gouri V. Patil ◽  
Rakesh S. Joshi ◽  
Rubina S. Kazi ◽  
Shabda E. Kulsange ◽  
Mahesh J. Kulkarni
Keyword(s):  
Amyloid Β ◽  
Protein Processing ◽  
Precursor Protein
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