Hippocampal Lesions in Rhesus Monkeys Disrupt Emotional Responses but Not Reinforcer Devaluation Effects

2008 ◽  
Vol 63 (11) ◽  
pp. 1084-1091 ◽  
Author(s):  
Yogita Chudasama ◽  
Katherine S. Wright ◽  
Elisabeth A. Murray
Keyword(s):  
Rhesus Monkeys ◽  
Emotional Responses ◽  
Hippocampal Lesions ◽  
Reinforcer Devaluation

Hippocampal lesions impair prolonged titrated avoidance by rhesus monkeys☆

1979 ◽  
Vol 63 (1) ◽  
pp. 28-34 ◽  
Author(s):  
William J. Jackson ◽  
Quentin R. Regestein
Keyword(s):  
Rhesus Monkeys ◽  
Hippocampal Lesions

scholarly journals Preserved visual memory and relational cognition performance in monkeys with selective hippocampal lesions

2020 ◽  
Vol 6 (29) ◽  
pp. eaaz0484 ◽  
Author(s):  
Benjamin M. Basile ◽  
Victoria L. Templer ◽  
Regina Paxton Gazes ◽  
Robert R. Hampton
Keyword(s):  
Nonhuman Primate ◽  
Source Memory ◽  
Rhesus Monkeys ◽  
Visual Memory ◽  
Temporal Order ◽  
Experimental Studies ◽  
Hippocampal Damage ◽  
Hippocampal Lesions ◽  
Hippocampus Proper ◽  
New Generation

The theory that the hippocampus is critical for visual memory and relational cognition has been challenged by discovery of more spared hippocampal tissue than previously reported in H.M., previously unreported extra-hippocampal damage in developmental amnesiacs, and findings that the hippocampus is unnecessary for object-in-context memory in monkeys. These challenges highlight the need for causal tests of hippocampal function in nonhuman primate models. Here, we tested rhesus monkeys on a battery of cognitive tasks including transitive inference, temporal order memory, shape recall, source memory, and image recognition. Contrary to predictions, we observed no robust impairments in memory or relational cognition either within- or between-groups following hippocampal damage. These results caution against over-generalizing from human correlational studies or rodent experimental studies, compel a new generation of nonhuman primate studies, and indicate that we should reassess the relative contributions of the hippocampus proper compared to other regions in visual memory and relational cognition.

Selective hippocampal lesions yield nonspatial memory impairments in rhesus monkeys

Hippocampus ◽  
1998 ◽  
Vol 8 (4) ◽  
pp. 323-329 ◽  
Author(s):  
F.Y. Dor� ◽  
J.A. Thornton ◽  
N.M. White ◽  
E.A. Murray
Keyword(s):  
Rhesus Monkeys ◽  
Memory Impairments ◽  
Hippocampal Lesions ◽  
Nonspatial Memory

Combined Unilateral Lesions of the Amygdala and Orbital Prefrontal Cortex Impair Affective Processing in Rhesus Monkeys

2004 ◽  
Vol 91 (5) ◽  
pp. 2023-2039 ◽  
Author(s):  
Alicia Izquierdo ◽  
Elisabeth A. Murray
Keyword(s):  
Prefrontal Cortex ◽  
Rhesus Monkeys ◽  
Hemispheric Specialization ◽  
Emotional Reactions ◽  
Reward Processing ◽  
Affective Processing ◽  
Processing Abilities ◽  
Combined Lesions ◽  
Reinforcer Devaluation ◽  
Orbital Prefrontal Cortex

The amygdala and orbital prefrontal cortex (PFo) interact as part of a system for affective processing. To assess whether there is a hemispheric functional specialization for the processing of emotion or reward or both in nonhuman primates, rhesus monkeys ( Macaca mulatta) with combined lesions of the amygdala and PFo in one hemisphere, either left or right, were compared with unoperated controls on a battery of tasks that tax affective processing, including two tasks that tax reward processing and two that assess emotional reactions. Although the two operated groups did not differ from each other, monkeys with unilateral lesions, left and right, showed altered reward-processing abilities as evidenced by attenuated reinforcer devaluation effects and an impairment in object reversal learning relative to controls. In addition, both operated groups showed blunted emotional reactions to a rubber snake. By contrast, monkeys with unilateral lesions did not differ from controls in their responses to an unfamiliar human (human “intruder”). Although the results provide no support for a hemispheric specialization of function, they yield the novel finding that unilateral lesions of the amygdala-orbitofrontal cortical circuit in monkeys are sufficient to significantly disrupt affective processing.

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