The Effects of Age and Stimulus Conditions on the Emotional Responses of Rhesus Monkeys: Responses to Complex Stimuli

Even without formal training, humans experience a wide range of emotions in response to changes in musical features, such as tonality and rhythm, during music listening. While many studies have investigated how isolated elements of tonal and rhythmic properties are processed in the human brain, it remains unclear whether these findings with such controlled stimuli are generalizable to complex stimuli in the real world. In the current study, we present an analytical framework of a linearized encoding analysis based on a set of music information retrieval features to investigate the rapid cortical encoding of tonal and rhythmic hierarchies in natural music. We applied this framework to a public domain EEG dataset (OpenMIIR) to deconvolve overlapping EEG responses to various musical features in continuous music. In particular, the proposed framework investigated the EEG encoding of the following features: tonal stability, key clarity, beat, and meter. This analysis revealed a differential spatiotemporal neural encoding of beat and meter, but not of tonal stability and key clarity. The results demonstrate that this framework can uncover associations of ongoing brain activity with relevant musical features, which could be further extended to other relevant measures such as time-resolved emotional responses in future studies.

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Socially mediated reduction in emotional responses of young rhesus monkeys.

Journal of Abnormal & Social Psychology ◽

10.1037/h0044088 ◽

1960 ◽

Vol 60 (1) ◽

pp. 100-104 ◽

Cited By ~ 19

Author(s):

William A. Mason

Keyword(s):

Rhesus Monkeys ◽

Emotional Responses ◽

Mediated Reduction

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Comparison of the Effects of Bilateral Orbital Prefrontal Cortex Lesions and Amygdala Lesions on Emotional Responses in Rhesus Monkeys

Journal of Neuroscience ◽

10.1523/jneurosci.1232-05.2005 ◽

2005 ◽

Vol 25 (37) ◽

pp. 8534-8542 ◽

Cited By ~ 114

Author(s):

A. Izquierdo

Keyword(s):

Prefrontal Cortex ◽

Rhesus Monkeys ◽

Emotional Responses ◽

Orbital Prefrontal Cortex ◽

Amygdala Lesions

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The Growth of Herpesvirus mulatto in Human Fibroblast

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100051232 ◽

1974 ◽

Vol 32 ◽

pp. 244-245

Author(s):

Glennelle Washington ◽

Philip P. McGrath ◽

Peter R. Graze ◽

Ivor Royston

Keyword(s):

Rhesus Monkey ◽

Microscopic Study ◽

Electron Microscopic Study ◽

Peripheral Blood ◽

Human Fibroblast ◽

Rhesus Monkeys ◽

Human Fibroblasts ◽

Electron Microscopic ◽

Specific Antisera ◽

Peripheral Blood Leucocytes

Herpes-like viruses were isolated from rhesus monkey peripheral blood leucocytes when co-cultivated with WI-38 cells. The virus was originally designated rhesus leucocyte-associated herpesvirus (LAHV) and subsequently called Herpesvirus mulatta (HVM). The original isolations were from juvenile rhesus monkeys shown to be free of antibody to rhesus cytomegalic virus. The virus could only be propagated in human or simian fibroblasts. Use of specific antisera developed from HVM showed no relationship between this virus and other herpesviruses. An electron microscopic study was undertaken to determine the morphology of Herpesvirus mulatta (HVM) in infected human fibroblasts.

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Nucleolar Segregation and Chronic Methanol Intoxication

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100063718 ◽

1969 ◽

Vol 27 ◽

pp. 360-361

Author(s):

Julio H. Garcia ◽

Janice P. Van Zandt

Keyword(s):

Body Weight ◽

Methyl Alcohol ◽

Rhesus Monkeys ◽

Repeated Administration ◽

Serum Levels ◽

Methanol Intoxication ◽

Intragastric Tube ◽

Nucleolar Segregation

Repeated administration of methyl alcohol to Rhesus monkeys (Maccaca mulata) by intragastric tube resulted in ultrastructural abnormalities of hepatocytes, which persisted in one animal twelve weeks after discontinuation of the methyl alcohol regime. With dosages ranging between 3.0 to 6.0 gms. of methanol per kg. of body weight, the serum levels attained within a few hours averaged approximately 475 mg. per cent.

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Evaluation of hippocampus in rhesus monkeys after chronic (1-year) inhalation exposure to marijuana: I. Electron microscopy

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100159539 ◽

1990 ◽

Vol 48 (3) ◽

pp. 398-399

Author(s):

A.M. Andrews ◽

S.W. Wilson ◽

A.C. Scallet ◽

S.F. Ali ◽

J. Bailey ◽

...

Keyword(s):

Synaptic Vesicles ◽

Rhesus Monkeys ◽

Low Dose ◽

Inhalation Exposure ◽

Synaptic Cleft ◽

High Dose ◽

Withdrawal Time ◽

Treatment Groups ◽

Ultrastructural Evidence ◽

Male Rhesus

Exposure of rhesus monkeys (Macaca mulatta) to marijuana via inhalation or to intravenous delta-9-tetrahydrocannabinol (THC), reportedly caused ultrastructural evidence of increased synaptic width. Chronic marijuana smoke in a single rhesus monkey examined after a six month withdrawal time caused ultrastructure changes in the septal, hippocampal and amygdala regions; the synaptic cleft was widened, electron opaque material was found in the cleft and in the pre- and postsynaptic regions, with some clumping of the synaptic vesicles. The objective of our study was to assess neuropathological alterations produced by chronic inhalation of marijuana smoke.Nineteen male rhesus monkeys, 3-5 years of age and weighing 3-8 kg, were divided into four treatment groups: a) sham control, b) placebo smoke (7 days/ week) c) low dose marijuana (2 times/week with 5 days/week sham) and d) high dose marijuana (7 times/week). A smoke exposure consisted of smoke from one cigarette (2.6% THC) burned down to 10 mm butt length. Smoke was administered via smoke generator (ADL II, Arthur D. Little, Inc. Cambridge, MA) and nose-mouth only masks (local production) equipped with one-way valves.

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Functional Magnetic Resonance Imaging Measures of Blood Flow Patterns in the Human Auditory Cortex in Response to Sound

Journal of Speech Language and Hearing Research ◽

10.1044/jslhr.4103.538 ◽

1998 ◽

Vol 41 (3) ◽

pp. 538-548 ◽

Cited By ~ 7

Author(s):

Sean C. Huckins ◽

Christopher W. Turner ◽

Karen A. Doherty ◽

Michael M. Fonte ◽

Nikolaus M. Szeverenyi

Keyword(s):

Magnetic Resonance Imaging ◽

Blood Flow ◽

Magnetic Resonance ◽

Functional Magnetic Resonance Imaging ◽

Functional Magnetic Resonance ◽

Resonance Imaging ◽

Speech Stimuli ◽

Complex Stimuli ◽

Scanning Session ◽

Auditory Research

Functional Magnetic Resonance Imaging (fMRI) holds exciting potential as a research and clinical tool for exploring the human auditory system. This noninvasive technique allows the measurement of discrete changes in cerebral cortical blood flow in response to sensory stimuli, allowing determination of precise neuroanatomical locations of the underlying brain parenchymal activity. Application of fMRI in auditory research, however, has been limited. One problem is that fMRI utilizing echo-planar imaging technology (EPI) generates intense noise that could potentially affect the results of auditory experiments. Also, issues relating to the reliability of fMRI for listeners with normal hearing need to be resolved before this technique can be used to study listeners with hearing loss. This preliminary study examines the feasibility of using fMRI in auditory research by performing a simple set of experiments to test the reliability of scanning parameters that use a high resolution and high signal-to-noise ratio unlike that presently reported in the literature. We used consonant-vowel (CV) speech stimuli to investigate whether or not we could observe reproducible and consistent changes in cortical blood flow in listeners during a single scanning session, across more than one scanning session, and in more than one listener. In addition, we wanted to determine if there were differences between CV speech and nonspeech complex stimuli across listeners. Our study shows reproducibility within and across listeners for CV speech stimuli. Results were reproducible for CV speech stimuli within fMRI scanning sessions for 5 out of 9 listeners and were reproducible for 6 out of 8 listeners across fMRI scanning sessions. Results of nonspeech complex stimuli across listeners showed activity in 4 out of 9 individuals tested.

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