rhesus monkeys
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2022 ◽  
Vol 14 (627) ◽  
Author(s):  
Wenping Li ◽  
Yuchuan Wang ◽  
Talakad G. Lohith ◽  
Zhizhen Zeng ◽  
Ling Tong ◽  
...  

[ 11 C]MK-6884 is an M4R-specific PET tracer for quantifying target engagement in brain and providing insights into AD neuropathology.


2022 ◽  
Author(s):  
Jessica Raper ◽  
Mark A.G. Eldridge ◽  
Scott Sternson ◽  
Jalene Y Shim ◽  
Grace P Fomani ◽  
...  

Chemogenetics is a technique for obtaining selective pharmacological control over a cell population by expressing an engineered receptor that is selectively activated by an exogenously administered ligand. A promising approach for neuronal modulation involves the use of Pharmacologically Selective Actuator Modules (PSAMs); these chemogenetic receptors are selectively activated by ultrapotent Pharmacologically Selective Effector Molecules (uPSEMs). To extend the use of PSAM/PSEMs to studies in nonhuman primates it is necessary to thoroughly characterize the efficacy and safety of these tools. We describe the time course and brain penetrance in rhesus monkeys of two compounds with promising binding specificity and efficacy profiles in in vitro studies, uPSEM792 and uPSEM817, after systemic administration. Rhesus macaques received subcutaneous (s.c.) or intravenous (i.v.) administration of uPSEM817(0.064 mg/kg) or uPSEM792 (0.87 mg/kg) and plasma and CSF samples were collected over the course of 48 hours. Both compounds exhibited good brain penetrance, relatively slow washout and negligible conversion to potential metabolites - varenicline or hydroxyvarenicline. In addition, we found that neither of these uPSEMs significantly altered heart rate or sleep. Our results indicate that both compounds are suitable candidates for neuroscience studies using PSAMs in nonhuman primates.


2022 ◽  
Vol 17 (5) ◽  
pp. 1131
Author(s):  
Guo-Chen Zhu ◽  
Da-Jiang Xiao ◽  
Bi-Wen Zhu ◽  
Yan Xiao

2022 ◽  
Author(s):  
Dan Shan ◽  
Xiaoyan Tang ◽  
Renqiang Liu ◽  
Dan Pan ◽  
Xijun Wang ◽  
...  
Keyword(s):  

Author(s):  
Lais F Berro ◽  
Tanya Pareek ◽  
Jaren A Reeves-Darby ◽  
Monica L Andersen ◽  
Leonard L Howell ◽  
...  

Rhesus monkeys are naturally social animals, and behavioral management strategies have focused on promoting pairhousingin laboratory settings as an alternative to individual or group housing. In humans, co-sleeping can have a major impact on bed partners’ sleep, raising the possibility that pair-housing also may influence sleep parameters in monkeys. In the present study, we investigated if pair-housing would impact home-cage partner’s sleep in female rhesus monkeys, and if nighttime separation using socialization panels would alter this pattern. Sleep parameters of 10 experimentally naïve adult female rhesus monkeys (5 pairs) were evaluated for 7 consecutive days using actigraphy monitors attached to primate collars. Paired animals then were separated by socialization panels during the night, and sleep-associated measures were evaluated for 7 consecutive days. The data showed that sleep efficiency was significantly lower when monkeys were pairhoused as compared with when they were separated. On the nights when subjects were pair-housed, a positive correlation was detected for sleep measures (both sleep latency and efficiency) of both members of a pair (R2’s = 0.16–0.5), suggesting that pair-housing influences sleep quality. On nights when subjects were separated, no correlations were observed for sleep measures between members of the pairs (R2’s = 0.004–0.01), suggesting that when separated, the home-cage partner’s sleep no longer influenced the partner’s sleep. Our results indicate that pair-housing has a strong impact on the home-cage partner’s sleep, and that this pattern can be prevented by nighttime separation using socialization panels. Studies evaluating sleep in pair-housed monkeys should consider the effects that the partner’s sleep may have on the subject’s sleep. Sleep is a biologic phenomenon and experimental outcome that affects physical and behavioral health and altered sleep due to pair-housing may affect a range of research outcomes.


2022 ◽  
Vol 137 ◽  
pp. 105078
Author(s):  
Sally B. Seraphin ◽  
Mar M. Sanchez ◽  
Patricia L. Whitten ◽  
James T. Winslow

2021 ◽  
pp. JN-RM-1275-21
Author(s):  
Alaa Al-Mohammad ◽  
Wolfram Schultz
Keyword(s):  

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