8-Substituted 1,3-dimethyltetrahydropyrazino[2,1- f ]purinediones: Water-soluble adenosine receptor antagonists and monoamine oxidase B inhibitors

2016 ◽  
Vol 24 (21) ◽  
pp. 5462-5480 ◽  
Author(s):  
Andreas Brunschweiger ◽  
Pierre Koch ◽  
Miriam Schlenk ◽  
Muhammad Rafehi ◽  
Hamid Radjainia ◽  
...  
Keyword(s):  
Monoamine Oxidase ◽  
Adenosine Receptor ◽  
Water Soluble ◽  
Monoamine Oxidase B ◽  
Receptor Antagonists

Ligand-Based Virtual Screening Using Tailored Ensembles: A Prioritization Tool for Dual A2A Adenosine Receptor Antagonists / Monoamine Oxidase B Inhibitors

2016 ◽  
Vol 22 (21) ◽  
pp. 3082-3096 ◽  
Author(s):  
Aliuska Morales Helguera ◽  
Yunierkis Perez-Castillo ◽  
M. Natália D.S. Cordeiro ◽  
Eduardo Tejera ◽  
César Paz-y-Miño ◽  
...  
Keyword(s):  
Virtual Screening ◽  
Monoamine Oxidase ◽  
Adenosine Receptor ◽  
Monoamine Oxidase B ◽  
Receptor Antagonists ◽  
A2a Adenosine Receptor

scholarly journals Virtual screening tailored ensembles of QSAR models for the discovery of dual A2A Adenosine Receptor Antagonists / Monoamine Oxidase B Inhibitors

2015 ◽  
Author(s):  
Fernanda Borges ◽  
Maykel Cruz-Monteagudo ◽  
Aliuska Morales-Helguera ◽  
Yunierkis Pérez-Castillo ◽  
M. Natália D. S. Cordeiro ◽  
...  
Keyword(s):  
Virtual Screening ◽  
Monoamine Oxidase ◽  
Adenosine Receptor ◽  
Monoamine Oxidase B ◽  
Receptor Antagonists ◽  
Qsar Models

A2A-selective adenosine receptor antagonists: Development of water-soluble prodrugs and a new tritiated radioligand

1998 ◽  
Vol 45 (3-4) ◽  
pp. 190-197 ◽  
Author(s):  
Christa E. M�ller ◽  
Roland Sauer ◽  
Yuris Maurinsh ◽  
Rosa Huertas ◽  
Friederike F�lle ◽  
...  
Keyword(s):  
Adenosine Receptor ◽  
Water Soluble ◽  
Receptor Antagonists

Inhibition of monoamine oxidase B by selective adenosine A 2A receptor antagonists

2003 ◽  
Vol 11 (7) ◽  
pp. 1299-1310 ◽  
Author(s):  
Jacobus P Petzer ◽  
Salome Steyn ◽  
Kay P Castagnoli ◽  
Jiang-Fan Chen ◽  
Michael A Schwarzschild ◽  
...  
Keyword(s):  
Monoamine Oxidase ◽  
Monoamine Oxidase B ◽  
Receptor Antagonists

Exploring Basic Tail Modifications of Coumarin-Based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-Soluble, Brain-Permeant Neuroprotective Multitarget Agents

2016 ◽  
Vol 59 (14) ◽  
pp. 6791-6806 ◽  
Author(s):  
Leonardo Pisani ◽  
Roberta Farina ◽  
Marco Catto ◽  
Rosa Maria Iacobazzi ◽  
Orazio Nicolotti ◽  
...  
Keyword(s):  
Monoamine Oxidase ◽  
Water Soluble ◽  
Monoamine Oxidase B

Water-Soluble Pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines as Human A3 Adenosine Receptor Antagonists

2012 ◽  
Vol 55 (11) ◽  
pp. 5380-5390 ◽  
Author(s):  
Pier Giovanni Baraldi ◽  
Giulia Saponaro ◽  
Romeo Romagnoli ◽  
Mojgan Aghazadeh Tabrizi ◽  
Stefania Baraldi ◽  
...  
Keyword(s):  
Adenosine Receptor ◽  
Water Soluble ◽  
Receptor Antagonists ◽  
A3 Adenosine Receptor

The adenosine receptor affinities and monoamine oxidase B inhibitory properties of sulfanylphthalimide analogues

2015 ◽  
Vol 59 ◽  
pp. 117-123 ◽  
Author(s):  
Mietha M. Van der Walt ◽  
Gisella Terre’Blanche ◽  
Anél Petzer ◽  
Jacobus P. Petzer
Keyword(s):  
Monoamine Oxidase ◽  
Adenosine Receptor ◽  
Monoamine Oxidase B

Water-Soluble Phosphate Prodrugs of 1-Propargyl-8-styrylxanthine Derivatives, A2A-Selective Adenosine Receptor Antagonists†

2000 ◽  
Vol 43 (3) ◽  
pp. 440-448 ◽  
Author(s):  
Roland Sauer ◽  
Juris Maurinsh ◽  
Ulrike Reith ◽  
Friederike Fülle ◽  
Karl-Norbert Klotz ◽  
...  
Keyword(s):  
Adenosine Receptor ◽  
Water Soluble ◽  
Soluble Phosphate ◽  
Receptor Antagonists

Imidazo[2,1-i]purin-5-ones and Related Tricyclic Water-Soluble Purine Derivatives:  Potent A2A- and A3-Adenosine Receptor Antagonists†

2002 ◽  
Vol 45 (16) ◽  
pp. 3440-3450 ◽  
Author(s):  
Christa E. Müller ◽  
Mark Thorand ◽  
Ramatullah Qurishi ◽  
Martina Diekmann ◽  
Kenneth A. Jacobson ◽  
...  
Keyword(s):  
Adenosine Receptor ◽  
Water Soluble ◽  
Purine Derivatives ◽  
Receptor Antagonists ◽  
A3 Adenosine Receptor

Novel multi-target directed ligands based on annelated xanthine scaffold with aromatic substituents acting on adenosine receptor and monoamine oxidase B. Synthesis, in vitro and in silico studies

2019 ◽  
Vol 27 (7) ◽  
pp. 1195-1210 ◽  
Author(s):  
Michał Załuski ◽  
Jakub Schabikowski ◽  
Miriam Schlenk ◽  
Agnieszka Olejarz-Maciej ◽  
Bartłomiej Kubas ◽  
...  
Keyword(s):  
Monoamine Oxidase ◽  
Adenosine Receptor ◽  
In Silico ◽  
Monoamine Oxidase B ◽  
In Silico Studies
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