Ketamine esters and amides as short-acting anaesthetics: Structure-activity relationships for the side-chain

2019 ◽  
Vol 27 (7) ◽  
pp. 1226-1231 ◽  
Author(s):  
Ivaylo V. Dimitrov ◽  
Martyn G. Harvey ◽  
Logan J. Voss ◽  
James W. Sleigh ◽  
Michael J. Bickerdike ◽  
...  
Keyword(s):  
Side Chain ◽  
Short Acting ◽  
Structure Activity Relationships ◽  
Structure Activity

Potential antitumor agents. 63. Structure-activity relationships for side-chain analogs of the colon 38 active agent 9-oxo-9H-xanthene-4-acetic acid

1991 ◽  
Vol 34 (9) ◽  
pp. 2864-2870 ◽  
Author(s):  
Gordon W. Rewcastle ◽  
Graham J. Atwell ◽  
Bruce C. Baguley ◽  
Maruta Boyd ◽  
Lindy L. Thomsen ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Antitumor Agents ◽  
Active Agent ◽  
Side Chain ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Potential Antitumor

Structure–activity relationships of the peptide deformylase inhibitor BB-3497: modification of the methylene spacer and the P1′ side chain

2003 ◽  
Vol 13 (16) ◽  
pp. 2709-2713 ◽  
Author(s):  
Stephen J. Davies ◽  
Andrew P. Ayscough ◽  
R.Paul Beckett ◽  
Ryan A. Bragg ◽  
John M. Clements ◽  
...  
Keyword(s):  
Peptide Deformylase ◽  
Side Chain ◽  
Structure Activity Relationships ◽  
Structure Activity

Structure-Activity Relationships in Side-Chain-Modified Epothilone Analogues—How Important is the Position of the Nitrogen Atom?

ChemMedChem ◽  
2006 ◽  
Vol 1 (1) ◽  
pp. 37-40 ◽  
Author(s):  
Guido Bold ◽  
Séverine Wojeik ◽  
Giorgio Caravatti ◽  
Renate Lindauer ◽  
Claire Stierlin ◽  
...  
Keyword(s):  
Nitrogen Atom ◽  
Side Chain ◽  
Structure Activity Relationships ◽  
Structure Activity

Structure–activity relationships of side-chain modified didemnins

2001 ◽  
Vol 11 (2) ◽  
pp. 231-234 ◽  
Author(s):  
Xiaobin Ding ◽  
Matthew D. Vera ◽  
Bo Liang ◽  
Yuming Zhao ◽  
Michael S. Leonard ◽  
...  
Keyword(s):  
Side Chain ◽  
Structure Activity Relationships ◽  
Structure Activity

Structure–activity relationships of the ultrapotent vanilloid resiniferatoxin (RTX): The side chain benzylic methylene

2010 ◽  
Vol 20 (1) ◽  
pp. 97-99 ◽  
Author(s):  
Giovanni Appendino ◽  
Abdellah Ech-Chahad ◽  
Alberto Minassi ◽  
Luciano De Petrocellis ◽  
Vincenzo Di Marzo
Keyword(s):  
Side Chain ◽  
Structure Activity Relationships ◽  
Structure Activity

Orally active cephalosporins. Part 2: Synthesis, structure–activity relationships and oral absorption of cephalosporins having a C-3 pyridyl side chain

2000 ◽  
Vol 8 (5) ◽  
pp. 1159-1170 ◽  
Author(s):  
Hirofumi Yamamoto ◽  
Takeshi Terasawa ◽  
Ayako Nakamura ◽  
Kohji Kawabata ◽  
Kazuo Sakane ◽  
...  
Keyword(s):  
Oral Absorption ◽  
Side Chain ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Orally Active

An attempt at the hydrated imidazoline ring expansion (HIRE) of diarene-fused [1,4]diazepinones delivers selective dopamine D2 receptor ligands

Synthesis ◽  
2021 ◽  
Author(s):  
Sergey Grintsevich ◽  
Alexander V. Sapegin ◽  
Andrzej Bojarski ◽  
Beata Duszyńska ◽  
Mikhail Krasavin
Keyword(s):  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Ring Expansion ◽  
Side Chain ◽  
Receptor Ligands ◽  
Structure Activity Relationships ◽  
Dopamine D2 ◽  
Structure Activity ◽  
Imidazoline Ring ◽  
Selective Dopamine

Attempts to extend the hydrated imidazoline ring expansion (HIRE) strategy to a series of diarene-fused [1,4]diazepinones (earlier applied successfully to bis-pyrido substrate nevirapine) resulted in no ring expansion but rather 2-aminoethyl side chain expulsion. This seeming setback (setting the limitations to the HIRE methodology substrate scope) led to the discovery of selective dopamine D2 ligands with elements of structure-activity relationships.

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