Design and synthesis of thiazole-5-hydroxamic acids as novel histone deacetylase inhibitors

2007 ◽  
Vol 17 (21) ◽  
pp. 5995-5999 ◽  
Author(s):  
Sampath-Kumar Anandan ◽  
John S. Ward ◽  
Richard D. Brokx ◽  
Trisha Denny ◽  
Mark R. Bray ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitors ◽  
Hydroxamic Acids ◽  
Design And Synthesis

scholarly journals Design and Synthesis of Terephthalic Acid-Based Histone Deacetylase Inhibitors with Dual-Stage Anti-PlasmodiumActivity

ChemMedChem ◽  
2017 ◽  
Vol 12 (19) ◽  
pp. 1627-1636 ◽  
Author(s):  
Katharina Stenzel ◽  
Ming Jang Chua ◽  
Sandra Duffy ◽  
Yevgeniya Antonova-Koch ◽  
Stephan Meister ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Terephthalic Acid ◽  
Histone Deacetylase Inhibitors ◽  
Design And Synthesis ◽  
Dual Stage

Benzofused hydroxamic acids: Useful fragments for the preparation of histone deacetylase inhibitors. Part 2: 7-Fluorobenzothiophenes and benzofurans

2015 ◽  
Vol 25 (7) ◽  
pp. 1603-1606 ◽  
Author(s):  
Elena Marastoni ◽  
Sandra Bartoli ◽  
Marco Berettoni ◽  
Amalia Cipollone ◽  
Alessandro Ettorre ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitors ◽  
Hydroxamic Acids

New Benzothiazole/thiazole-Containing Hydroxamic Acids as Potent Histone Deacetylase Inhibitors and Antitumor Agents

2013 ◽  
Vol 9 (8) ◽  
pp. 1051-1057 ◽  
Author(s):  
Truong Tung ◽  
Dao Kim Oanh ◽  
Phan Phuong Dung ◽  
Van My Hue ◽  
Sang Park ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitors ◽  
Antitumor Agents ◽  
Hydroxamic Acids

Design and synthesis of 4-[(s-triazin-2-ylamino)methyl]-N-(2-aminophenyl)-benzamides and their analogues as a novel class of histone deacetylase inhibitors

2008 ◽  
Vol 18 (3) ◽  
pp. 1067-1071 ◽  
Author(s):  
Isabelle Paquin ◽  
Stéphane Raeppel ◽  
Silvana Leit ◽  
Frédéric Gaudette ◽  
Nancy Zhou ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitors ◽  
Design And Synthesis

scholarly journals Synthesis of thiazolyl-based hydroxamic acids as histone deacetylase inhibitors

ARKIVOC ◽  
2020 ◽  
Vol 2020 (7) ◽  
pp. 228-241
Author(s):  
Yodita Asfaha ◽  
Alexander Jan Skerhut ◽  
Leandro A. Alves-Avelar ◽  
Nadine Horstick-Muche ◽  
Beate Lungerich ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitors ◽  
Hydroxamic Acids

scholarly journals Design and Synthesis of Small Molecules Based on a Substructural Analysis of the Histone Deacetylase Inhibitors TSA and SAHA

2011 ◽  
Vol 8 (3) ◽  
pp. 1394-1400
Author(s):  
Lynda Ekou ◽  
Tchirioua Ekou ◽  
Javier Garcia ◽  
Isabelle Opalinski ◽  
Jean Pierre Gesson
Keyword(s):  
Small Molecules ◽  
Histone Deacetylase ◽  
Histone Deacetylases ◽  
Hydroxamic Acid ◽  
Histone Deacetylase Inhibitors ◽  
Suberoylanilide Hydroxamic Acid ◽  
Considerable Potential ◽  
Design And Synthesis

Inhibitors of histone deacetylases (HDACs) are patent inducers of differentiation and bear considerable potential as drugs for chemoprevention and treatment of cancer. In this paper, we have investigated three synthetic, inhibitors A1a,b, A2a. Analogue hybrid trichostatine A (TSA), suberoylanilide hydroxamic acid SAHA, in order to seek new histone deacetylases (HDACs) inhibitors.

Novel isatin-based hydroxamic acids as histone deacetylase inhibitors and antitumor agents

2013 ◽  
Vol 70 ◽  
pp. 477-486 ◽  
Author(s):  
Nguyen-Hai Nam ◽  
Tran Lan Huong ◽  
Do Thi Mai Dung ◽  
Phan Thi Phuong Dung ◽  
Dao Thi Kim Oanh ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitors ◽  
Antitumor Agents ◽  
Hydroxamic Acids

Design and synthesis of non-hydroxamate histone deacetylase inhibitors: identification of a selective histone acetylating agent

2005 ◽  
Vol 13 (13) ◽  
pp. 4332-4342 ◽  
Author(s):  
Takayoshi Suzuki ◽  
Azusa Matsuura ◽  
Akiyasu Kouketsu ◽  
Shinya Hisakawa ◽  
Hidehiko Nakagawa ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitors ◽  
Design And Synthesis
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