Scaffold hopping from pyridones to imidazo[1,2-a]pyridines. New positive allosteric modulators of metabotropic glutamate 2 receptor

Gary Tresadern; Jose María Cid; Gregor J. Macdonald; Juan Antonio Vega; Ana Isabel de Lucas; Aránzazu García; Encarnación Matesanz; María Lourdes Linares; Daniel Oehlrich; Hilde Lavreysen; Ilse Biesmans; Andrés A. Trabanco

doi:10.1016/j.bmcl.2009.11.008

Scaffold hopping from pyridones to imidazo[1,2-a]pyridines. New positive allosteric modulators of metabotropic glutamate 2 receptor

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2009.11.008 ◽

2010 ◽

Vol 20 (1) ◽

pp. 175-179 ◽

Cited By ~ 55

Author(s):

Gary Tresadern ◽

Jose María Cid ◽

Gregor J. Macdonald ◽

Juan Antonio Vega ◽

Ana Isabel de Lucas ◽

...

Keyword(s):

Allosteric Modulators ◽

Scaffold Hopping ◽

Metabotropic Glutamate ◽

Positive Allosteric Modulators

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Scaffold Hopping to Imidazo[1,2-a]pyrazin-8-one Positive Allosteric Modulators of Metabotropic Glutamate 2 Receptor

ACS Omega ◽

10.1021/acsomega.1c03739 ◽

2021 ◽

Author(s):

Ana I. de Lucas ◽

Juan A. Vega ◽

Aránzazu García Molina ◽

María Lourdes Linares ◽

Gary Tresadern ◽

...

Keyword(s):

Allosteric Modulators ◽

Scaffold Hopping ◽

Metabotropic Glutamate ◽

Positive Allosteric Modulators

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Discovery of novel positive allosteric modulators of the α7 nicotinic acetylcholine receptor: Scaffold hopping approach

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2021.113189 ◽

2021 ◽

Vol 214 ◽

pp. 113189

Author(s):

István Ledneczki ◽

Pál Tapolcsányi ◽

Eszter Gábor ◽

András Visegrády ◽

Márton Vass ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Allosteric Modulators ◽

Scaffold Hopping ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Positive Allosteric Modulators

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Exploring the Active Conformation of Cyclohexane Carboxylate Positive Allosteric Modulators of the Type 4 Metabotropic Glutamate Receptor

ChemMedChem ◽

10.1002/cmdc.201402190 ◽

2014 ◽

Vol 9 (12) ◽

pp. 2685-2698 ◽

Cited By ~ 1

Author(s):

Xavier Rovira ◽

Youssef Harrak ◽

Ana Trapero ◽

Patricia González-Bulnes ◽

Fanny Malhaire ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Allosteric Modulators ◽

Active Conformation ◽

Metabotropic Glutamate ◽

Cyclohexane Carboxylate ◽

Positive Allosteric Modulators

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Identification and optimisation of a series of tetrahydrobenzotriazoles as metabotropic glutamate receptor 5-selective positive allosteric modulators that improve performance in a preclinical model of cognition

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2015.10.050 ◽

2015 ◽

Vol 25 (24) ◽

pp. 5792-5796 ◽

Cited By ~ 5

Author(s):

John M. Ellard ◽

Andrew Madin ◽

Oliver Philps ◽

Mark Hopkin ◽

Scott Henderson ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Preclinical Model ◽

Allosteric Modulators ◽

Improve Performance ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate ◽

Positive Allosteric Modulators

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Metabotropic Glutamate Receptor 2 Positive Allosteric Modulators: Closing the Gate on Drug Abuse?

Biological Psychiatry ◽

10.1016/j.biopsych.2015.07.008 ◽

2015 ◽

Vol 78 (7) ◽

pp. 436-438 ◽

Cited By ~ 1

Author(s):

Kari A. Johnson ◽

David M. Lovinger

Keyword(s):

Drug Abuse ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Allosteric Modulators ◽

Metabotropic Glutamate ◽

Positive Allosteric Modulators

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Positive allosteric modulators of the metabotropic glutamate receptor 2 for the treatment of schizophrenia

Expert Opinion on Therapeutic Patents ◽

10.1517/13543770903045009 ◽

2009 ◽

Vol 19 (9) ◽

pp. 1259-1275 ◽

Cited By ~ 36

Author(s):

Mark E Fraley

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Allosteric Modulators ◽

Metabotropic Glutamate ◽

Positive Allosteric Modulators

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N-Aryl Piperazine Metabotropic Glutamate Receptor 5 Positive Allosteric Modulators Possess Efficacy in Preclinical Models of NMDA Hypofunction and Cognitive Enhancement

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.113.206623 ◽

2013 ◽

Vol 347 (2) ◽

pp. 438-457 ◽

Cited By ~ 34

Author(s):

K.J. Gregory ◽

E.J. Herman ◽

A.J. Ramsey ◽

A.S. Hammond ◽

N.E. Byun ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Cognitive Enhancement ◽

Allosteric Modulators ◽

Preclinical Models ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate ◽

Positive Allosteric Modulators

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Development of 1H-Pyrazolo[3,4-b]pyridines as Metabotropic Glutamate Receptor 5 Positive Allosteric Modulators

ACS Medicinal Chemistry Letters ◽

10.1021/acsmedchemlett.6b00292 ◽

2016 ◽

Vol 7 (12) ◽

pp. 1082-1086 ◽

Cited By ~ 12

Author(s):

Matthew D. Hill ◽

Haiquan Fang ◽

Jeffrey M. Brown ◽

Thaddeus Molski ◽

Amy Easton ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Allosteric Modulators ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate ◽

Positive Allosteric Modulators

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New positive allosteric modulators of the metabotropic glutamate receptor 2 (mGluR2): Identification and synthesis of N-propyl-8-chloro-6-substituted isoquinolones

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2010.12.048 ◽

2011 ◽

Vol 21 (3) ◽

pp. 971-976 ◽

Cited By ~ 15

Author(s):

Andrés A. Trabanco ◽

Guillaume Duvey ◽

José María Cid ◽

Gregor J. Macdonald ◽

Philippe Cluzeau ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Allosteric Modulators ◽

Metabotropic Glutamate ◽

Positive Allosteric Modulators

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4-(1-Phenyl-1H-pyrazol-4-yl)quinolines as novel, selective and brain penetrant metabotropic glutamate receptor 4 positive allosteric modulators

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2012.03.032 ◽

2012 ◽

Vol 22 (9) ◽

pp. 3235-3239 ◽

Cited By ~ 13

Author(s):

Hermogenes N. Jimenez ◽

Kevin G. Liu ◽

Sang-Phyo Hong ◽

Michael S. Reitman ◽

Michelle A. Uberti ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Allosteric Modulators ◽

Metabotropic Glutamate ◽

Positive Allosteric Modulators

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