Synthesis and biological evaluation of substituted 2-benzoylpyridine thiosemicarbazones: Novel structure–activity relationships underpinning their anti-proliferative and chelation efficacy

Adeline Y. Lukmantara; Danuta S. Kalinowski; Naresh Kumar; Des R. Richardson

doi:10.1016/j.bmcl.2012.12.044

Synthesis and biological evaluation of substituted 2-benzoylpyridine thiosemicarbazones: Novel structure–activity relationships underpinning their anti-proliferative and chelation efficacy

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2012.12.044 ◽

2013 ◽

Vol 23 (4) ◽

pp. 967-974 ◽

Cited By ~ 28

Author(s):

Adeline Y. Lukmantara ◽

Danuta S. Kalinowski ◽

Naresh Kumar ◽

Des R. Richardson

Keyword(s):

Biological Evaluation ◽

Structure Activity Relationships ◽

Structure Activity ◽

Novel Structure ◽

Synthesis And Biological Evaluation

Download Full-text

Synthesis and Biological Evaluation of 14-Alkoxymorphinans. 18.1N-Substituted 14-Phenylpropyloxymorphinan-6-ones with Unanticipated Agonist Properties: Extending the Scope of Common Structure−Activity Relationships

Journal of Medicinal Chemistry ◽

10.1021/jm021118o ◽

2003 ◽

Vol 46 (9) ◽

pp. 1758-1763 ◽

Cited By ~ 23

Author(s):

Elisabeth Greiner ◽

Mariana Spetea ◽

Roland Krassnig ◽

Falko Schüllner ◽

Mario Aceto ◽

...

Keyword(s):

Biological Evaluation ◽

Structure Activity Relationships ◽

Common Structure ◽

Structure Activity ◽

Synthesis And Biological Evaluation

Download Full-text

Taxol structure-activity relationships: synthesis and biological evaluation of 10-deoxytaxol

The Journal of Organic Chemistry ◽

10.1021/jo00063a001 ◽

1993 ◽

Vol 58 (11) ◽

pp. 2927-2928 ◽

Cited By ~ 32

Author(s):

Shu Hui Chen ◽

Craig Fairchild ◽

Stephen W. Mamber ◽

Vittorio Farina

Keyword(s):

Biological Evaluation ◽

Structure Activity Relationships ◽

Structure Activity ◽

Synthesis And Biological Evaluation

Download Full-text

ChemInform Abstract: Structure-Activity Relationships Among DNA Gyrase Inhibitors. Synthesis and Biological Evaluation of 1,2-Dihydro-4,4-dimethyl-1-oxo-2-naphthalenecarboxylic Acids as 1-Carba Bioisosteres of Oxolinic Acid.

Chemischer Informationsdienst ◽

10.1002/chin.198432158 ◽

1984 ◽

Vol 15 (32) ◽

Author(s):

T. HOEGBERG ◽

I. KHANNA ◽

S. D. DRAKE ◽

L. A. MITSCHER ◽

L. L. SHEN

Keyword(s):

Dna Gyrase ◽

Biological Evaluation ◽

Oxolinic Acid ◽

Structure Activity Relationships ◽

Structure Activity ◽

Abstract Structure ◽

Synthesis And Biological Evaluation ◽

Gyrase Inhibitors

Download Full-text

Structure–activity relationships in platelet-activating factor. Part 13: Synthesis and biological evaluation of piperazine derivatives with dual anti-PAF and anti-HIV-1 or pure antiretroviral activity

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2006.07.031 ◽

2006 ◽

Vol 14 (23) ◽

pp. 8109-8125 ◽

Cited By ~ 13

Author(s):

Nawal Serradji ◽

Okkacha Bensaid ◽

Marc Martin ◽

Wafa Sallem ◽

Nathalie Dereuddre-Bosquet ◽

...

Keyword(s):

Platelet Activating Factor ◽

Biological Evaluation ◽

Structure Activity Relationships ◽

Piperazine Derivatives ◽

Structure Activity ◽

Synthesis And Biological Evaluation ◽

Anti Hiv ◽

Hiv 1 ◽

Antiretroviral Activity

Download Full-text

ChemInform Abstract: Structure-Activity Relationships Study at the 3′-N Position of Paclitaxel. Part 1. Synthesis and Biological Evaluation of the 3′-(t)-Butylaminocarbonyloxy Bearing Paclitaxel Analogues.

ChemInform ◽

10.1002/chin.199812164 ◽

2010 ◽

Vol 29 (12) ◽

pp. no-no

Author(s):

S.-H. CHEN ◽

M. XUE ◽

S. HUANG ◽

B. H. LONG ◽

C. A. FAIRCHILD ◽

...

Keyword(s):

Biological Evaluation ◽

Structure Activity Relationships ◽

Structure Activity ◽

Abstract Structure ◽

Synthesis And Biological Evaluation

Download Full-text

Structure–activity relationships study at the 3′-N position of paclitaxel. part 2: synthesis and biological evaluation of 3′-N-thiourea- and 3′-N-thiocarbamate-bearing paclitaxel analogues

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/s0960-894x(00)00242-0 ◽

2000 ◽

Vol 10 (12) ◽

pp. 1327-1331 ◽

Cited By ~ 17

Author(s):

May Xue ◽

Byron H Long ◽

Craig Fairchild ◽

Kathy Johnston ◽

William C Rose ◽

...

Keyword(s):

Biological Evaluation ◽

Structure Activity Relationships ◽

Structure Activity ◽

Synthesis And Biological Evaluation

Download Full-text

Structure–activity relationships of IKM-159: Diverted synthesis and biological evaluation of a series of C5-oxy analogs

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2015.03.037 ◽

2015 ◽

Vol 25 (9) ◽

pp. 1869-1871 ◽

Cited By ~ 8

Author(s):

Manami Chiba ◽

Chikako Fujimoto ◽

Ryuichi Sakai ◽

Masato Oikawa

Keyword(s):

Biological Evaluation ◽

Structure Activity Relationships ◽

Structure Activity ◽

Synthesis And Biological Evaluation

Download Full-text

Taxol® structure-activity relationships: synthesis and biological evaluation of taxol analogs modified at C-7

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/s0960-894x(00)80075-x ◽

1994 ◽

Vol 4 (18) ◽

pp. 2223-2228 ◽

Cited By ~ 17

Author(s):

Shu-Hui Chen ◽

Joydeep Kant ◽

Stephen W. Mamber ◽

Gregory P. Roth ◽

Jian-Mei Wei ◽

...

Keyword(s):

Biological Evaluation ◽

Structure Activity Relationships ◽

Structure Activity ◽

Synthesis And Biological Evaluation

Download Full-text

Synthesis and biological evaluation of 14-(aminoalkyl-aminomethyl)aromathecins as topoisomerase I inhibitors: Investigating the hypothesis of shared structure–activity relationships

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2009.08.066 ◽

2009 ◽

Vol 17 (20) ◽

pp. 7145-7155 ◽

Cited By ~ 29

Author(s):

Maris A. Cinelli ◽

Brenda Cordero ◽

Thomas S. Dexheimer ◽

Yves Pommier ◽

Mark Cushman

Keyword(s):

Topoisomerase I ◽

Biological Evaluation ◽

Structure Activity Relationships ◽

Topoisomerase I Inhibitors ◽

Structure Activity ◽

Synthesis And Biological Evaluation ◽

Shared Structure

Download Full-text

Design, Synthesis, and Biological Evaluation of 1-[(Biarylmethyl)methylamino]-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ols as Potent Antifungal Agents: New Insights into Structure-Activity Relationships

ChemMedChem ◽

10.1002/cmdc.201100262 ◽

2011 ◽

Vol 6 (10) ◽

pp. 1806-1815 ◽

Cited By ~ 10

Author(s):

Rémi Guillon ◽

Fabrice Pagniez ◽

Charlotte Rambaud ◽

Carine Picot ◽

Muriel Duflos ◽

...

Keyword(s):

Antifungal Agents ◽

Biological Evaluation ◽

Design Synthesis ◽

Structure Activity Relationships ◽

Structure Activity ◽

Synthesis And Biological Evaluation

Download Full-text